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About 17,889 results

ALLMedicine™ Neurodegenerative Disorders Center

Research & Reviews  8,855 results

In situ architecture of neuronal α-Synuclein inclusions.
https://doi.org/10.1038/s41467-021-22108-0
Nature Communications; Trinkaus VA, Riera-Tur I et. al.

Apr 15th, 2021 - The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were long thought to consist mainly of α-Syn fibrils, but recent reports pointed to intracellular...

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propaga...
https://doi.org/10.1038/s41467-021-22501-9 10.1016/j.neuron.2011.04.009 10.1016/0896-6273(93)90279-Z 10.1016/0896-6273(93)90057-X 10.1016/0014-5793(92)80767-B 10.1093/hmg/ddt402 10.1038/ncomms1255 10.1093/brain/aws013 10.1016/j.ajpath.2013.04.025 10.1016/j.neuron.2010.08.044 10.1016/S1474-4422(13)70090-5 10.1016/j.cell.2020.01.027 10.1016/j.neuron.2016.03.005 10.1038/nm.3951 10.1186/1750-1326-5-45 10.1096/fj.11-199851 10.1038/nature08890 10.1007/BF00308809 10.1038/nature12481 10.1038/ncb1901 10.1186/s13024-016-0143-y 10.1016/j.nbd.2012.05.021 10.1186/s13024-019-0354-0 10.1016/j.pneurobio.2012.01.003 10.1016/j.pneurobio.2013.03.001 10.1016/S1474-4422(18)30238-2 10.1038/nm.3232 10.1016/j.cell.2011.10.026 10.1093/hmg/ddp367 10.1111/j.1460-9568.2008.06084.x 10.1093/brain/aws143 10.1186/1750-1326-7-48 10.1093/jnen/64.2.113 10.1007/s00401-011-0896-x 10.1016/j.cell.2010.05.008 10.1038/s41580-018-0001-6 10.1016/0968-0004(90)90019-8 10.1126/science.2799391 10.1126/science.273.5274.501 10.1128/MCB.02070-07 10.1083/jcb.137.4.825 10.1016/j.devcel.2010.12.003 10.4161/auto.4451 10.1074/jbc.272.9.5606 10.1096/fj.09-144519 10.1016/S0076-6879(08)03619-7 10.1016/S0021-9258(18)47204-3 10.1038/ncomms1393 10.1016/j.molcel.2010.08.004 10.1016/j.bmcl.2007.11.027 10.1016/j.celrep.2012.06.005 10.1016/j.ceb.2015.04.016 10.3389/fimmu.2014.00403 10.1083/jcb.201811173 10.1074/jbc.M112.409250 10.1016/bs.mcb.2017.06.014 10.1126/sciadv.aaw6404 10.1126/science.1101738 10.1038/nn.3350 10.1016/j.cell.2009.03.018 10.1371/journal.pbio.3000301 10.1111/acel.13081 10.3389/fnins.2019.00698 10.1074/jbc.M002102200 10.1016/j.neuron.2011.04.009 10.1212/WNL.52.1.91 10.1016/j.neuroimage.2013.02.059 10.1016/j.cmet.2014.06.009 10.1038/nature04723 10.1111/acel.12310 10.1073/pnas.0507436103 10.1002/cpcb.51 10.1091/mbc.e04-06-0477 10.1007/s00401-013-1080-2 10.1074/jbc.M113.521997 10.1021/cb3002599 10.1016/j.ab.2007.08.020 10.1083/jcb.93.1.144 10.1016/1074-7613(95)90080-2 10.1006/meth.2001.1262 10.1016/S0021-9258(19)52451-6 10.1073/pnas.76.9.4350
Nature Communications; Caballero B, Bourdenx M et. al.

Apr 15th, 2021 - Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early pathological event in neurodegeneration. In this work, we find th...

Naringenin mitigates behavioral alterations and provides neuroprotection against 3-nitr...
https://doi.org/10.1080/1028415X.2021.1913319
Nutritional Neuroscience; Salman M, Sharma P et. al.

Apr 15th, 2021 - Naringenin is a powerful antioxidant and anti-inflammatory flavonoid which has been widely used as a therapeutic agent in various toxic models. However, few studies have clearly discussed the neuromodulatory effects of naringenin against different...

The Use, Standardization, and Interpretation of Brain Imaging Data in Clinical Trials o...
https://doi.org/10.1007/s13311-021-01027-4 10.1001/jama.2015.4669 10.1016/j.jalz.2015.05.001 10.1016/j.jalz.2015.06.1893 10.1056/NEJMoa1304839 10.1002/ana.25123 10.1056/NEJMoa1705971 10.1056/NEJMoa1812840 10.1186/s13195-018-0438-z 10.1016/S1474-4422(13)70044-9 10.1212/WNL.0000000000002923 10.1016/j.jalz.2018.02.018 10.1001/jamaneurol.2020.2526 10.1016/S1474-4422(12)70142-4 10.2967/jnumed.115.161927 10.1016/j.dadm.2017.06.001 10.2967/jnumed.114.142109 10.1016/j.nicl.2017.04.025 10.2967/jnumed.111.090340 10.1016/j.nicl.2019.101800 10.3389/fnins.2017.00281 10.1007/s00259-011-1821-1 10.1002/ana.23908 10.1016/j.jalz.2015.05.018 10.1007/s00401-018-1897-9 10.1212/WNL.0000000000004643 10.1038/s41467-017-01150-x 10.1212/WNL.0000000000004733 10.1007/BF00308809 10.1007/s00401-006-0127-z 10.1093/brain/aww023 10.1038/s41467-018-05892-0 10.1016/j.dadm.2015.09.001 10.1016/j.jalz.2016.03.009 10.1111/cts.12492 10.1111/cts.12619 10.1016/j.jalz.2013.07.003 10.1016/j.neurobiolaging.2013.09.039 10.1212/WNL.0000000000003126 10.1002/mds.27122 10.1136/jnnp.55.10.967 10.1007/s00330-011-2205-4 10.1161/01.STR.0000049766.26453.E9 10.1136/jnnp-2014-309645 10.1371/journal.pone.0189897 10.1016/j.autneu.2017.10.007 10.1038/npp.2008.166 10.2165/00023210-200115090-00001 10.1124/jpet.115.229278 10.1186/s13550-020-0616-4 10.1016/j.drudis.2011.12.020 10.1001/jamaneurol.2014.1954 10.1212/WNL.0000000000002391 10.1002/mds.27963 10.1093/brain/awv214 10.1093/brain/awv219 10.1038/s41591-019-0478-3 10.1002/ana.410340114 10.1016/S0140-6736(01)05625-2 10.1186/2191-219X-3-30 10.1093/brain/awt145 10.1186/s12974-015-0236-5 10.1093/brain/aww017 10.1038/jcbfm.2011.147 10.2967/jnumed.110.087031 10.1038/srep16404 10.1093/brain/awv404 10.1093/brain/awz260 10.1177/1536012118792317 10.1177/0962280214537344 10.1016/j.jalz.2017.02.009 10.1001/archneurol.2011.1538 10.1038/nature19323 10.1186/s13195-019-0559-z 10.1093/brain/awx171 10.2967/jnumed.118.209650 10.2967/jnumed.118.208215 10.2967/jnumed.119.236224 10.1093/brain/aww027 10.1093/cercor/bhn113 10.1016/j.parkreldis.2011.10.013 10.1111/ene.12675 10.1007/s00415-016-8252-7 10.1016/B978-0-12-801893-4.00020-1 10.1080/21678421.2017.1407795 10.1007/s00415-018-9087-1 10.1002/ana.25297 10.1007/s11940-018-0504-7 10.1016/j.neurobiolaging.2017.10.008 10.1002/mds.27606 10.1111/j.1479-8301.2010.00325.x 10.1016/j.neuroimage.2011.01.049 10.1016/j.nicl.2018.08.006 10.2967/jnumed.115.166272 10.1007/s00415-006-0383-9 10.3988/jcn.2013.9.1.21 10.1016/j.neurobiolaging.2010.03.015 10.1002/ana.24018 10.1212/WNL.0000000000004743 10.1007/s00415-008-0750-9 10.1177/1352458517729456 10.1016/S1474-4422(13)70103-0 10.1016/j.jalz.2011.05.2351 10.1056/NEJMoa1312889 10.1038/jcbfm.2015.66 10.2967/jnumed.115.170027 10.1177/1536012120947582 10.2967/jnumed.119.236240 10.1088/0031-9155/60/22/R363 10.1186/s13195-018-0402-y 10.2967/jnumed.117.200964 10.2967/jnumed.115.168732 10.1016/j.nicl.2016.10.005 10.3233/JAD-181188 10.1016/j.neurobiolaging.2015.09.018 10.1016/j.jalz.2014.12.002 10.1016/j.neuroimage.2016.05.016 10.1016/j.neuroimage.2017.05.019 10.1002/ana.22628 10.1016/j.nicl.2020.102243 10.1038/s41598-018-25459-9 10.2967/jnumed.115.171595 10.1007/s00259-017-3749-6 10.1016/j.neuroimage.2018.08.044 10.1186/s13550-018-0456-7 10.1016/j.jalz.2018.06.1353 10.1016/j.jalz.2016.08.005 10.1186/s13195-019-0478-z 10.1007/s00259-020-04942-4 10.1016/j.nicl.2018.04.022 10.2967/jnumed.118.210518 10.2967/jnumed.117.194720 10.1212/WNL.0000000000011031 10.1016/j.neuron.2012.10.029 10.1016/j.jalz.2011.03.003 10.1084/jem.20120741 10.1212/WNL.58.12.1791 10.1016/j.neuron.2016.01.028 10.1038/s41467-019-14159-1 10.1038/s41467-020-15701-2 10.3233/JAD-190264 10.1007/s00401-019-02077-x 10.3233/JPD-179001 10.1016/S0197-4580(02)00065-9 10.1093/brain/awm177 10.1177/1352458512473190 10.1177/1352458514556300 10.1016/j.trci.2019.05.007 10.1093/brain/awy319 10.1002/ana.21606 10.1212/WNL.0b013e3181ea15aa 10.1186/s13195-020-00679-2 10.1016/j.jalz.2017.09.013 10.1002/hbm.24056 10.1016/j.neuroimage.2012.03.072 10.1056/NEJMoa1706441 10.1186/s13195-018-0424-5 10.1016/S1474-4422(17)30124-2 10.1212/WNL.0000000000005005 10.1016/j.dadm.2019.08.009 10.1038/s41598-021-81705-7 10.1016/j.jalz.2018.02.013 10.1212/NXI.0000000000000271 10.1016/j.jalz.2018.01.013 10.1038/s41591-020-0762-2 10.3389/fncel.2018.00366 10.1186/s12974-019-1531-3 10.1038/s41467-020-19543-w
Neurotherapeutics : the Journal of the American Society F... Schwarz AJ

Apr 13th, 2021 - Imaging biomarkers play a wide-ranging role in clinical trials for neurological disorders. This includes selecting the appropriate trial participants, establishing target engagement and mechanism-related pharmacodynamic effect, monitoring safety, ...

WDR45, one gene associated with multiple neurodevelopmental disorders.
https://doi.org/10.1080/15548627.2021.1899669
Autophagy Cong Y, So V et. al.

Apr 12th, 2021 - The WDR45 gene is localized on the X-chromosome and variants in this gene are linked to six different neurodegenerative disorders, i.e., ß-propeller protein associated neurodegeneration, Rett-like syndrome, intellectual disability, and epileptic e...

see more →

Guidelines  7 results

Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688056/
Cureus Sangle P

Oct 25th, 2020 - Depression is a common mental health condition occurring across all ages, genders, and populations and is almost always multifaceted. It can manifest as a form of metabolic disorder, endocrine disorder, cardiovascular diseases, inflammatory disord...

An outlook on the role of decaffeinated coffee in neurodegenerative diseases
https://www.tandfonline.com/doi/abs/10.1080/10408398.2018.1550384?journalCode=bfsn20
Critical Reviews in Food Science and Nutrition; Colombo,R.,et al

Jan 6th, 2019 - Coffee is reported to be among the most widely consumed beverages in the world and coffee consumption has been associated with reductions in the risk of several chronic diseases. Among its constituents, caffeine represents the most investigated co...

Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225145/
Molecules Idea,K.,et al

Sep 22nd, 2018 - Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders worldwide. Its incidence is gradually increasing because of an aging demographic. Therefore, AD prevention and modification is important to improve the health status of...

European Association of Nuclear Medicine and European Academy of Neurology recommendati...
https://doi.org/10.1111/ene.13728
European Journal of Neurology; Nobili F, Arbizu J et. al.

Jun 22nd, 2018 - Recommendations for using fluorodeoxyglucose positron emission tomography (FDG-PET) to support the diagnosis of dementing neurodegenerative disorders are sparse and poorly structured. Twenty-one questions on diagnostic issues and on semi-automated...

Best practice guide for the treatment of REM sleep behavior disorder (RBD).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823283
Journal of Clinical Sleep Medicine : JCSM : Official Publ... Aurora RN, Zak RS et. al.

Mar 2nd, 2010 - Modifying the sleep environment is recommended for the treatment of patients with RBD who have sleep-related injury. Level A Clonazepam is suggested for the treatment of RBD but should be used with caution in patients with dementia, gait disorders...

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Clinicaltrials.gov  8,929 results

In situ architecture of neuronal α-Synuclein inclusions.
https://doi.org/10.1038/s41467-021-22108-0
Nature Communications; Trinkaus VA, Riera-Tur I et. al.

Apr 15th, 2021 - The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were long thought to consist mainly of α-Syn fibrils, but recent reports pointed to intracellular...

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propaga...
https://doi.org/10.1038/s41467-021-22501-9 10.1016/j.neuron.2011.04.009 10.1016/0896-6273(93)90279-Z 10.1016/0896-6273(93)90057-X 10.1016/0014-5793(92)80767-B 10.1093/hmg/ddt402 10.1038/ncomms1255 10.1093/brain/aws013 10.1016/j.ajpath.2013.04.025 10.1016/j.neuron.2010.08.044 10.1016/S1474-4422(13)70090-5 10.1016/j.cell.2020.01.027 10.1016/j.neuron.2016.03.005 10.1038/nm.3951 10.1186/1750-1326-5-45 10.1096/fj.11-199851 10.1038/nature08890 10.1007/BF00308809 10.1038/nature12481 10.1038/ncb1901 10.1186/s13024-016-0143-y 10.1016/j.nbd.2012.05.021 10.1186/s13024-019-0354-0 10.1016/j.pneurobio.2012.01.003 10.1016/j.pneurobio.2013.03.001 10.1016/S1474-4422(18)30238-2 10.1038/nm.3232 10.1016/j.cell.2011.10.026 10.1093/hmg/ddp367 10.1111/j.1460-9568.2008.06084.x 10.1093/brain/aws143 10.1186/1750-1326-7-48 10.1093/jnen/64.2.113 10.1007/s00401-011-0896-x 10.1016/j.cell.2010.05.008 10.1038/s41580-018-0001-6 10.1016/0968-0004(90)90019-8 10.1126/science.2799391 10.1126/science.273.5274.501 10.1128/MCB.02070-07 10.1083/jcb.137.4.825 10.1016/j.devcel.2010.12.003 10.4161/auto.4451 10.1074/jbc.272.9.5606 10.1096/fj.09-144519 10.1016/S0076-6879(08)03619-7 10.1016/S0021-9258(18)47204-3 10.1038/ncomms1393 10.1016/j.molcel.2010.08.004 10.1016/j.bmcl.2007.11.027 10.1016/j.celrep.2012.06.005 10.1016/j.ceb.2015.04.016 10.3389/fimmu.2014.00403 10.1083/jcb.201811173 10.1074/jbc.M112.409250 10.1016/bs.mcb.2017.06.014 10.1126/sciadv.aaw6404 10.1126/science.1101738 10.1038/nn.3350 10.1016/j.cell.2009.03.018 10.1371/journal.pbio.3000301 10.1111/acel.13081 10.3389/fnins.2019.00698 10.1074/jbc.M002102200 10.1016/j.neuron.2011.04.009 10.1212/WNL.52.1.91 10.1016/j.neuroimage.2013.02.059 10.1016/j.cmet.2014.06.009 10.1038/nature04723 10.1111/acel.12310 10.1073/pnas.0507436103 10.1002/cpcb.51 10.1091/mbc.e04-06-0477 10.1007/s00401-013-1080-2 10.1074/jbc.M113.521997 10.1021/cb3002599 10.1016/j.ab.2007.08.020 10.1083/jcb.93.1.144 10.1016/1074-7613(95)90080-2 10.1006/meth.2001.1262 10.1016/S0021-9258(19)52451-6 10.1073/pnas.76.9.4350
Nature Communications; Caballero B, Bourdenx M et. al.

Apr 15th, 2021 - Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early pathological event in neurodegeneration. In this work, we find th...

Naringenin mitigates behavioral alterations and provides neuroprotection against 3-nitr...
https://doi.org/10.1080/1028415X.2021.1913319
Nutritional Neuroscience; Salman M, Sharma P et. al.

Apr 15th, 2021 - Naringenin is a powerful antioxidant and anti-inflammatory flavonoid which has been widely used as a therapeutic agent in various toxic models. However, few studies have clearly discussed the neuromodulatory effects of naringenin against different...

The Use, Standardization, and Interpretation of Brain Imaging Data in Clinical Trials o...
https://doi.org/10.1007/s13311-021-01027-4 10.1001/jama.2015.4669 10.1016/j.jalz.2015.05.001 10.1016/j.jalz.2015.06.1893 10.1056/NEJMoa1304839 10.1002/ana.25123 10.1056/NEJMoa1705971 10.1056/NEJMoa1812840 10.1186/s13195-018-0438-z 10.1016/S1474-4422(13)70044-9 10.1212/WNL.0000000000002923 10.1016/j.jalz.2018.02.018 10.1001/jamaneurol.2020.2526 10.1016/S1474-4422(12)70142-4 10.2967/jnumed.115.161927 10.1016/j.dadm.2017.06.001 10.2967/jnumed.114.142109 10.1016/j.nicl.2017.04.025 10.2967/jnumed.111.090340 10.1016/j.nicl.2019.101800 10.3389/fnins.2017.00281 10.1007/s00259-011-1821-1 10.1002/ana.23908 10.1016/j.jalz.2015.05.018 10.1007/s00401-018-1897-9 10.1212/WNL.0000000000004643 10.1038/s41467-017-01150-x 10.1212/WNL.0000000000004733 10.1007/BF00308809 10.1007/s00401-006-0127-z 10.1093/brain/aww023 10.1038/s41467-018-05892-0 10.1016/j.dadm.2015.09.001 10.1016/j.jalz.2016.03.009 10.1111/cts.12492 10.1111/cts.12619 10.1016/j.jalz.2013.07.003 10.1016/j.neurobiolaging.2013.09.039 10.1212/WNL.0000000000003126 10.1002/mds.27122 10.1136/jnnp.55.10.967 10.1007/s00330-011-2205-4 10.1161/01.STR.0000049766.26453.E9 10.1136/jnnp-2014-309645 10.1371/journal.pone.0189897 10.1016/j.autneu.2017.10.007 10.1038/npp.2008.166 10.2165/00023210-200115090-00001 10.1124/jpet.115.229278 10.1186/s13550-020-0616-4 10.1016/j.drudis.2011.12.020 10.1001/jamaneurol.2014.1954 10.1212/WNL.0000000000002391 10.1002/mds.27963 10.1093/brain/awv214 10.1093/brain/awv219 10.1038/s41591-019-0478-3 10.1002/ana.410340114 10.1016/S0140-6736(01)05625-2 10.1186/2191-219X-3-30 10.1093/brain/awt145 10.1186/s12974-015-0236-5 10.1093/brain/aww017 10.1038/jcbfm.2011.147 10.2967/jnumed.110.087031 10.1038/srep16404 10.1093/brain/awv404 10.1093/brain/awz260 10.1177/1536012118792317 10.1177/0962280214537344 10.1016/j.jalz.2017.02.009 10.1001/archneurol.2011.1538 10.1038/nature19323 10.1186/s13195-019-0559-z 10.1093/brain/awx171 10.2967/jnumed.118.209650 10.2967/jnumed.118.208215 10.2967/jnumed.119.236224 10.1093/brain/aww027 10.1093/cercor/bhn113 10.1016/j.parkreldis.2011.10.013 10.1111/ene.12675 10.1007/s00415-016-8252-7 10.1016/B978-0-12-801893-4.00020-1 10.1080/21678421.2017.1407795 10.1007/s00415-018-9087-1 10.1002/ana.25297 10.1007/s11940-018-0504-7 10.1016/j.neurobiolaging.2017.10.008 10.1002/mds.27606 10.1111/j.1479-8301.2010.00325.x 10.1016/j.neuroimage.2011.01.049 10.1016/j.nicl.2018.08.006 10.2967/jnumed.115.166272 10.1007/s00415-006-0383-9 10.3988/jcn.2013.9.1.21 10.1016/j.neurobiolaging.2010.03.015 10.1002/ana.24018 10.1212/WNL.0000000000004743 10.1007/s00415-008-0750-9 10.1177/1352458517729456 10.1016/S1474-4422(13)70103-0 10.1016/j.jalz.2011.05.2351 10.1056/NEJMoa1312889 10.1038/jcbfm.2015.66 10.2967/jnumed.115.170027 10.1177/1536012120947582 10.2967/jnumed.119.236240 10.1088/0031-9155/60/22/R363 10.1186/s13195-018-0402-y 10.2967/jnumed.117.200964 10.2967/jnumed.115.168732 10.1016/j.nicl.2016.10.005 10.3233/JAD-181188 10.1016/j.neurobiolaging.2015.09.018 10.1016/j.jalz.2014.12.002 10.1016/j.neuroimage.2016.05.016 10.1016/j.neuroimage.2017.05.019 10.1002/ana.22628 10.1016/j.nicl.2020.102243 10.1038/s41598-018-25459-9 10.2967/jnumed.115.171595 10.1007/s00259-017-3749-6 10.1016/j.neuroimage.2018.08.044 10.1186/s13550-018-0456-7 10.1016/j.jalz.2018.06.1353 10.1016/j.jalz.2016.08.005 10.1186/s13195-019-0478-z 10.1007/s00259-020-04942-4 10.1016/j.nicl.2018.04.022 10.2967/jnumed.118.210518 10.2967/jnumed.117.194720 10.1212/WNL.0000000000011031 10.1016/j.neuron.2012.10.029 10.1016/j.jalz.2011.03.003 10.1084/jem.20120741 10.1212/WNL.58.12.1791 10.1016/j.neuron.2016.01.028 10.1038/s41467-019-14159-1 10.1038/s41467-020-15701-2 10.3233/JAD-190264 10.1007/s00401-019-02077-x 10.3233/JPD-179001 10.1016/S0197-4580(02)00065-9 10.1093/brain/awm177 10.1177/1352458512473190 10.1177/1352458514556300 10.1016/j.trci.2019.05.007 10.1093/brain/awy319 10.1002/ana.21606 10.1212/WNL.0b013e3181ea15aa 10.1186/s13195-020-00679-2 10.1016/j.jalz.2017.09.013 10.1002/hbm.24056 10.1016/j.neuroimage.2012.03.072 10.1056/NEJMoa1706441 10.1186/s13195-018-0424-5 10.1016/S1474-4422(17)30124-2 10.1212/WNL.0000000000005005 10.1016/j.dadm.2019.08.009 10.1038/s41598-021-81705-7 10.1016/j.jalz.2018.02.013 10.1212/NXI.0000000000000271 10.1016/j.jalz.2018.01.013 10.1038/s41591-020-0762-2 10.3389/fncel.2018.00366 10.1186/s12974-019-1531-3 10.1038/s41467-020-19543-w
Neurotherapeutics : the Journal of the American Society F... Schwarz AJ

Apr 13th, 2021 - Imaging biomarkers play a wide-ranging role in clinical trials for neurological disorders. This includes selecting the appropriate trial participants, establishing target engagement and mechanism-related pharmacodynamic effect, monitoring safety, ...

WDR45, one gene associated with multiple neurodevelopmental disorders.
https://doi.org/10.1080/15548627.2021.1899669
Autophagy Cong Y, So V et. al.

Apr 12th, 2021 - The WDR45 gene is localized on the X-chromosome and variants in this gene are linked to six different neurodegenerative disorders, i.e., ß-propeller protein associated neurodegeneration, Rett-like syndrome, intellectual disability, and epileptic e...

see more →

News  97 results

Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688056/
Cureus Sangle P

Oct 25th, 2020 - Depression is a common mental health condition occurring across all ages, genders, and populations and is almost always multifaceted. It can manifest as a form of metabolic disorder, endocrine disorder, cardiovascular diseases, inflammatory disord...

Blood Biomarker May Predict Parkinson's Disease Progression
https://www.medscape.com/viewarticle/937198

Sep 9th, 2020 - A novel biomarker could help identify progression in Parkinson's disease, distinguish it from other neurodegenerative disorders, and monitor response to treatments. Although the biomarker, neurofilament light chain (NfL), is not especially specifi...

P-tau217 Differentiates AD vs Other Neurodegenerative Conditions
https://www.staging.medscape.com/viewarticle/934831

Jul 28th, 2020 - A blood test that measures plasma tau phosphorylated at threonine 217 (P-tau217) can accurately distinguish Alzheimer's disease (AD) from other neurodegenerative disorders, new research suggests. Results from a large multinational study showed tha...

P-tau217 Differentiates AD vs Other Neurodegenerative Conditions
https://www.medscape.com/viewarticle/934831

Jul 28th, 2020 - A blood test that measures plasma tau phosphorylated at threonine 217 (P-tau217) can accurately distinguish Alzheimer's disease (AD) from other neurodegenerative disorders, new research suggests. Results from a large multinational study showed tha...

Degenerative Disorders Account for Rising Share of US Neurological Disease Deaths
https://www.medscape.com/viewarticle/933003

Jun 25th, 2020 - (Reuters Health) - Neurological disease mortality rates in the U.S. are similar to what they were two decades ago, but over time the main cause of these deaths has shifted from cerebrovascular diseases to Alzheimer's dementia and other neurodegene...

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