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About 4,603 results

ALLMedicine™ Progressive Supranuclear Palsy Center

Research & Reviews  2,249 results

Dantrolene for muscle rigidity in progressive supranuclear palsy.
https://doi.org/10.1136/bmjspcare-2021-003047
BMJ Supportive & Palliative Care; Khan N

May 6th, 2021 - Progressive supranuclear palsy is a degenerative neurological condition with a high level of associated motor symptom burden manifesting in poor postural reflexes, bradykinesia, dystonia and stiffness in the body core and neck. In the light of a p...

LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neur...
https://doi.org/10.1007/s00401-021-02313-3 10.1007/s00415-006-0234-8 10.1038/nature20414 10.1073/pnas.0503689102 10.1155/2016/2108495 10.1038/emm.2014.128 10.1126/science.7403847 10.1038/nature11003 10.1186/2045-8118-11-17 10.1002/mds.27431 10.1126/sciadv.abb2454 10.1016/j.tins.2017.04.001 10.1007/s00418-008-0436-5 10.1016/S0197-4580(02)00065-9 10.1111/j.1600-0854.2009.00933.x 10.1186/1750-1326-7-31 10.1038/nrn2620 10.1002/mds.27693 10.1073/pnas.1800165115 10.1529/biophysj.103.038422 10.1364/BOE.4.002644 10.2174/187152709787601867 10.1016/j.stemcr.2018.12.011 10.1111/j.1600-0854.2008.00786.x 10.3233/JPD-181474 10.1073/pnas.1812196115 10.1007/s00401-020-02177-z 10.1523/JNEUROSCI.2272-11.2012 10.1038/nrneurol.2012.242 10.1007/s00401-010-0741-7 10.1007/s00109-012-0984-y 10.1038/nature18928 10.1038/sdata.2018.160 10.1002/mds.21956 10.1093/hmg/ddv314 10.1038/ejhg.2017.87 10.1016/j.cell.2019.04.001 10.1126/science.1225829 10.1007/s00702-014-1353-5 10.1016/j.celrep.2020.107719 10.1038/ng0298-106 10.1093/jnen/62.12.1241 10.1093/nar/gkz365 10.1074/jbc.M109.081125 10.1111/j.1750-3639.2007.00048.x 10.1186/s40478-014-0093-y 10.1038/nature21029 10.1126/science.8493557 10.1016/S1474-4422(17)30122-9 10.1016/j.cell.2014.12.019 10.1006/meth.2001.1262 10.1007/s00401-017-1746-2 10.1093/hmg/ddw185 10.1073/pnas.1913904117 10.1038/ncpneuro0355 10.1212/wnl.0000000000004058 10.1001/jamaneurol.2013.1925 10.1126/sciadv.abb5398 10.1016/j.neurobiolaging.2020.06.013 10.1109/tsmc.1979.4310076 10.1016/j.neuron.2004.10.023 10.1016/S0304-3940(03)00781-X 10.3389/fnmol.2017.00054 10.1126/science.276.5321.2045 10.1002/mds.26424 10.1016/S1474-4422(18)30179-0 10.1371/journal.pone.0059252 10.1038/ng1943 10.1523/JNEUROSCI.0983-17.2017 10.1001/archneur.61.8.1200 10.1038/ncomms5028 10.1038/s41593-019-0423-2 10.1056/NEJMoa0901281 10.1007/s00401-009-0619-8 10.1016/j.neuroscience.2008.10.061 10.1111/jnc.14704 10.1038/ncb2721 10.1016/j.nbd.2015.04.009 10.15252/embj.201695773 10.1038/nature25739 10.1017/s0033291713000494 10.3233/JAD-200318 10.1016/j.parkreldis.2019.05.037 10.1016/j.neubiorev.2018.03.028 10.15252/embj.201592705 10.1038/s41591-018-0051-5 10.1002/ana.10795 10.1016/j.neuron.2015.11.013 10.1016/j.neuron.2004.11.005
Acta Neuropathologica; Grochowska MM, Carreras Mascaro A et. al.

Apr 29th, 2021 - Loss-of-function variants in the low-density lipoprotein receptor-related protein 10 (LRP10) gene have been associated with autosomal-dominant Parkinson's disease (PD), PD dementia, and dementia with Lewy bodies (DLB). Moreover, LRP10 variants hav...

Two heterozygous progranulin mutations in progressive supranuclear palsy.
https://doi.org/10.1093/brain/awaa428
Brain : a Journal of Neurology; Yang W, Deng B et. al.

Apr 12th, 2021 - Two heterozygous progranulin mutations in progressive supranuclear palsy.|2021|Yang W,Deng B,Huang Y,Liu J,Huang Z,|

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Guidelines  2 results

EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia.
https://doi.org/10.1111/j.1468-1331.2012.03784.x
European Journal of Neurology; Sorbi S, Hort J et. al.

Aug 15th, 2012 - The last version of the EFNS dementia guidelines is from 2007. In 2010, the revised guidelines for Alzheimer's disease (AD) were published. The current guidelines involve the revision of the dementia syndromes outside of AD, notably vascular cogni...

Imaging in Parkinson’s disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280219/
Clinical Medicine;

The clinical presentation of Parkinson’s disease (PD) is heterogeneous and overlaps with other conditions, including the parkinsonian variant of multiple system atrophy (MSA-P), progressive supranuclear palsy (PSP) and essential tremor. Imaging of...

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Drugs  1 results see all →

Clinicaltrials.gov  2,299 results

Dantrolene for muscle rigidity in progressive supranuclear palsy.
https://doi.org/10.1136/bmjspcare-2021-003047
BMJ Supportive & Palliative Care; Khan N

May 6th, 2021 - Progressive supranuclear palsy is a degenerative neurological condition with a high level of associated motor symptom burden manifesting in poor postural reflexes, bradykinesia, dystonia and stiffness in the body core and neck. In the light of a p...

LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neur...
https://doi.org/10.1007/s00401-021-02313-3 10.1007/s00415-006-0234-8 10.1038/nature20414 10.1073/pnas.0503689102 10.1155/2016/2108495 10.1038/emm.2014.128 10.1126/science.7403847 10.1038/nature11003 10.1186/2045-8118-11-17 10.1002/mds.27431 10.1126/sciadv.abb2454 10.1016/j.tins.2017.04.001 10.1007/s00418-008-0436-5 10.1016/S0197-4580(02)00065-9 10.1111/j.1600-0854.2009.00933.x 10.1186/1750-1326-7-31 10.1038/nrn2620 10.1002/mds.27693 10.1073/pnas.1800165115 10.1529/biophysj.103.038422 10.1364/BOE.4.002644 10.2174/187152709787601867 10.1016/j.stemcr.2018.12.011 10.1111/j.1600-0854.2008.00786.x 10.3233/JPD-181474 10.1073/pnas.1812196115 10.1007/s00401-020-02177-z 10.1523/JNEUROSCI.2272-11.2012 10.1038/nrneurol.2012.242 10.1007/s00401-010-0741-7 10.1007/s00109-012-0984-y 10.1038/nature18928 10.1038/sdata.2018.160 10.1002/mds.21956 10.1093/hmg/ddv314 10.1038/ejhg.2017.87 10.1016/j.cell.2019.04.001 10.1126/science.1225829 10.1007/s00702-014-1353-5 10.1016/j.celrep.2020.107719 10.1038/ng0298-106 10.1093/jnen/62.12.1241 10.1093/nar/gkz365 10.1074/jbc.M109.081125 10.1111/j.1750-3639.2007.00048.x 10.1186/s40478-014-0093-y 10.1038/nature21029 10.1126/science.8493557 10.1016/S1474-4422(17)30122-9 10.1016/j.cell.2014.12.019 10.1006/meth.2001.1262 10.1007/s00401-017-1746-2 10.1093/hmg/ddw185 10.1073/pnas.1913904117 10.1038/ncpneuro0355 10.1212/wnl.0000000000004058 10.1001/jamaneurol.2013.1925 10.1126/sciadv.abb5398 10.1016/j.neurobiolaging.2020.06.013 10.1109/tsmc.1979.4310076 10.1016/j.neuron.2004.10.023 10.1016/S0304-3940(03)00781-X 10.3389/fnmol.2017.00054 10.1126/science.276.5321.2045 10.1002/mds.26424 10.1016/S1474-4422(18)30179-0 10.1371/journal.pone.0059252 10.1038/ng1943 10.1523/JNEUROSCI.0983-17.2017 10.1001/archneur.61.8.1200 10.1038/ncomms5028 10.1038/s41593-019-0423-2 10.1056/NEJMoa0901281 10.1007/s00401-009-0619-8 10.1016/j.neuroscience.2008.10.061 10.1111/jnc.14704 10.1038/ncb2721 10.1016/j.nbd.2015.04.009 10.15252/embj.201695773 10.1038/nature25739 10.1017/s0033291713000494 10.3233/JAD-200318 10.1016/j.parkreldis.2019.05.037 10.1016/j.neubiorev.2018.03.028 10.15252/embj.201592705 10.1038/s41591-018-0051-5 10.1002/ana.10795 10.1016/j.neuron.2015.11.013 10.1016/j.neuron.2004.11.005
Acta Neuropathologica; Grochowska MM, Carreras Mascaro A et. al.

Apr 29th, 2021 - Loss-of-function variants in the low-density lipoprotein receptor-related protein 10 (LRP10) gene have been associated with autosomal-dominant Parkinson's disease (PD), PD dementia, and dementia with Lewy bodies (DLB). Moreover, LRP10 variants hav...

Two heterozygous progranulin mutations in progressive supranuclear palsy.
https://doi.org/10.1093/brain/awaa428
Brain : a Journal of Neurology; Yang W, Deng B et. al.

Apr 12th, 2021 - Two heterozygous progranulin mutations in progressive supranuclear palsy.|2021|Yang W,Deng B,Huang Y,Liu J,Huang Z,|

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News  35 results

Negative Phase 2 Trial Data Ends Development of PSP Drug
https://www.medscape.com/viewarticle/922592

Dec 12th, 2019 - Topline results from the phase two PASSPORT trial show the experimental drug gosuranemab (BIIB092, Biogen) did not meet its primary or key secondary endpoints in patients with the atypical parkinsonian disorder of progressive supranuclear palsy (P...

The Falls and Frustrations of Progressive Supranuclear Palsy
https://www.medscape.com/viewarticle/921622

Nov 24th, 2019 - I often repeat her presentation to medical students: my only patient ever to fall walking into a clinic visit had progressive supranuclear palsy (PSP). Her impaired postural reflexes were no match for a set of brick steps. Perhaps she didn't notic...

How Accurately Do Current Criteria Identify CBD and PSP?
https://www.mdedge.com/neurology/article/167516/rare-diseases/how-accurately-do-current-criteria-identify-cbd-and-psp

Aug 2nd, 2018 - LOS ANGELES—Current criteria are comparatively insensitive and nonspecific for distinguishing between corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), according to research presented at the 70th Annual Meeting of the Ameri.

Blink Reflex Recovery Cycle Distinguishes Progressive Supranuclear Palsy From Corticobasal Degeneration
https://www.medscape.com/viewarticle/886962

Oct 11th, 2017 - KYOTO, Japan — The R2 component of the blink reflex recovery cycle (R2 BRRC) appears to be a useful tool to distinguish progressive supranuclear palsy (PSP) from corticobasal degeneration (CBD) with high sensitivity and specificity when the differ...

CurePSP International Research Symposium to Take Place in San Francisco
https://www.mdedge.com/familymedicine/article/148150/rare-diseases/curepsp-international-research-symposium-take-place-san
Neurology Reviews;

Sep 27th, 2017 - CurePSP (Progressive Supranuclear Palsy) will host an international research symposium at the Mission Bay Conference Center at UCSF in San Francisco on Oct. 26-27, 2017.

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Patient Education  17 results see all →