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About 1,788 results

ALLMedicine™ Chorea Center

Research & Reviews  606 results

The association of saccadic abnormalities with rem sleep in patients with Huntington's ...
https://doi.org/10.1016/j.sleep.2021.10.035
Sleep Medicine; Annapureddy J, Ray S et. al.

Dec 3rd, 2021 - Huntington's disease (HD) is a progressive neurodegenerative disorder characterised by chorea, cognitive impairment, psychiatric and behavioral disturbances. Sleep disturbances including reduced REM sleep have been observed in HD. The aim of the s...

A Scoping Review of Palliative Care for Adults with Huntington's Disease: Current Pract...
https://doi.org/10.1089/jpm.2021.0308
Journal of Palliative Medicine; El-Sourady M, Martin S et. al.

Dec 2nd, 2021 - Context: Huntington's disease (HD) is a neurodegenerative disorder characterized by mid-life onset, cognitive decline, and behavioral disturbance. Objective: We conducted a review of the end-of-life (EOL) experience of HD patients and their famili...

Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway.
https://doi.org/10.1016/j.nbd.2021.105574
Neurobiology of Disease; Barry J, Bui MTN et. al.

Dec 2nd, 2021 - Huntington's disease (HD) is a heritable, fatal neurodegenerative disorder caused by a mutation in the Huntingtin gene. It is characterized by chorea, as well as cognitive and psychiatric symptoms. Histopathologically, there is a massive loss of s...

Sporadic Huntington's disease in the Philippines: a case report.
https://doi.org/10.2217/nmt-2021-0023
Neurodegenerative Disease Management; Batino LKJ, Hiyadan J et. al.

Nov 18th, 2021 - Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder with core clinical features of choreoathetosis, cognitive deficits and behavioral changes. It is a rare disorder, primarily affecting the Caucasian population, and rarel...

Alternatives for Reducing Chorea in Huntington Disease
https://clinicaltrials.gov/ct2/show/NCT01897896

Nov 9th, 2021 - The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of SD-809 extended release (ER) in participants switching from tetrabenazine to SD-809 ER. In addition, the safety and tolerability of long-term treatment with...

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Guidelines  1 results

EULAR recommendations for the management of systemic lupus erythematosus with neuropsyc...
https://doi.org/10.1136/ard.2010.130476
Annals of the Rheumatic Diseases; Bertsias GK, Ioannidis JP et. al.

Aug 21st, 2010 - To develop recommendations for the diagnosis, prevention and treatment of neuropsychiatric systemic lupus erythematosus (NPSLE) manifestations. The authors compiled questions on prevalence and risk factors, diagnosis and monitoring, therapy and pr...

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Drugs  57 results see all →

Clinicaltrials.gov  10 results

Alternatives for Reducing Chorea in Huntington Disease
https://clinicaltrials.gov/ct2/show/NCT01897896

Nov 9th, 2021 - The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of SD-809 extended release (ER) in participants switching from tetrabenazine to SD-809 ER. In addition, the safety and tolerability of long-term treatment with...

Risperidone for the Treatment of Huntington's Disease Involuntary Movements
https://clinicaltrials.gov/ct2/show/NCT04201834

Nov 3rd, 2021 - The purpose of this study is to assess the safety and benefit of risperidone for the treatment of chorea (involuntary movements) in Huntington's disease. Risperidone is commonly used in clinical practice to treat chorea, however, it has not been a...

Deep Brain Stimulation Treatment for Chorea in Huntington's Disease
https://clinicaltrials.gov/ct2/show/NCT04244513

Apr 8th, 2021 - 1. Evaluating therapeutic effects of GPi-DBS on HD patients with chorea: Clinical data of patients at different treatment time points will be collected, using different clinical assessments. The clinical case report form for HD-DBS is consistent w...

Trial of Kuvan in Lesch-Nyhan Disease
https://clinicaltrials.gov/ct2/show/NCT00935753

Aug 2nd, 2019 - Lesch-Nyhan disease (LND) is an X-linked disorder of purine metabolism which results from mutation in the gene for the enzyme hypoxanthineguanine phosphoribosyltransferase (HPRT); patients have hyperuricemia, gout, urinary tract calculi, and nephr...

Open-label Extension Study of Pridopidine (ACR16) in the Symptomatic Treatment of Huntington Disease
https://clinicaltrials.gov/ct2/show/NCT01306929

Mar 6th, 2019 - Huntington disease (HD) is a hereditary neurodegenerative disorder causing impairment in movement, behavioral dysfunction and dementia. The movement disorder is mainly characterized by chorea (involuntary movements) and a progressive loss of volun...

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News  37 results

Fast Five Quiz: Huntington Disease Signs and Symptoms
https://reference.medscape.com/viewarticle/929783_6

May 27th, 2020 - Initiation of saccadic movements is slow and uncoordinated, and smooth pursuit is interrupted by saccadic intrusions. Patients are unable to inhibit saccades toward a peripheral stimulus when instructed to look in the opposite direction. Eye movem...

Fast Five Quiz: Huntington Disease
https://reference.medscape.com/viewarticle/929780

May 27th, 2020 - Huntington disease (HD) is a genetic neurodegenerative disorder named after Dr George Huntington, who in 1872 reported his observations of dementia and chorea that ran in families on the East End of Long Island, New York. The disease is now known ...

Fast Five Quiz: Huntington Disease
https://reference.medscape.com/viewarticle/929780_3

May 27th, 2020 - The initial stages of Huntington disease are often characterized by deficits in short-term memory. This is frequently followed by motor dysfunction and a variety of cognitive changes, including diminished verbal fluency and problems with attention...

Fast Five Quiz: Tardive Dyskinesia Differential Diagnosis
https://reference.medscape.com/viewarticle/923959_3

Feb 21st, 2020 - Postural instability frequently occurs in patients with Huntington disease, but it is uncommon in patients with neuroleptic-induced tardive dyskinesia. Unlike tardive dyskinesia, Huntington disease appears with chorea (derived from the Greek word ...

Therapeutic Genome Editing Shows Promise, but Numerous Challenges Remain
https://www.medscape.com/viewarticle/925163

Feb 13th, 2020 - NEW YORK (Reuters Health) - Current technology has allowed for the identification of genetic mutations associated with various diseases, but there is a growing separation between diagnostics and treatments, according to a new report. "Genome editi...

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Patient Education  4 results see all →