About 4,208 results

ALLMedicine™ Essential Tremor Center

Research & Reviews  1,355 results

Motor features associated with cognition in non-demented individuals with essential tre...
Journal of the Neurological Sciences; Peterson A, Chapman S et. al.

Jun 26th, 2022 - Essential tremor (ET) is a clinically heterogeneous disease characterized by motor and non-motor features, including cognitive impairment. In a cross-sectional analysis, we determined whether the presence and severity of motor features of ET are a...

Is essential tremor a family of diseases or a syndrome? A syndrome.
International Review of Neurobiology; Pandey S

Jun 25th, 2022 - In a consensus statement, a task force of the "International Parkinson and Movement Disorder Society" (IPMDS) has recently proposed a two axes classification for tremor: axis I (clinical manifestations) and axis II (etiology). In the axis, I, the ...

Enhancing GABA inhibition is the next generation of medications for essential tremor.
International Review of Neurobiology; Ondo W

Jun 25th, 2022 - γ-Aminobutyric acid (GABA) is the most prevalent inhibitory CNS neurotransmitter. Activating GABA-A receptors hyperpolarizes cells via Cl- influx, which inhibits action potentials. Although the exact pathophysiologies of tremor are incompletely un...

Is essential tremor a family of diseases or a syndrome? A family of diseases.
International Review of Neurobiology; Riboldi GM, Frucht SJ

Jun 25th, 2022 - It is now well-established that essential tremor (ET) can manifest with different clinical presentations and progressions (i.e., upper limb tremor, head tremor, voice tremor, lower limb tremor, task- or position-specific tremor, or a combination o...

Is essential tremor a degenerative or an electrical disorder? Electrical disorder.
International Review of Neurobiology; Cho HJ

Jun 25th, 2022 - Essential tremor (ET) is one of the most common movement disorders, yet we do not have a complete understanding of its pathophysiology. From a phenomenology standpoint, ET is an isolated tremor syndrome of bilateral upper limb action tremor with o...

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Drugs  38 results see all →

Clinicaltrials.gov  186 results

Deep Brain Stimulation (DBS) Sedation

Jun 24th, 2022 - Deep brain stimulation (DBS) of different brain nuclei is evolving as an essential component of the treatment for multiple brain disorders. The subthalamic nucleus (STN) and globus pallidus have been used to treat advanced Parkinson's disease for ...

Neuropathology of Spasmodic Dysphonia

Jun 24th, 2022 - Spasmodic dysphonia (SD) is a focal dystonia affecting the neural control of the laryngeal musculature for speech production. Although the clinical symptoms of SD have been described, the underlying pathological mechanisms remain unknown. Treatmen...

Clinical and Physiological Studies of Tremor Syndromes

Jun 24th, 2022 - Objectives The purpose of this protocol is to study the phenotypic spectrum and the pathophysiology of tremor syndromes by performing small behavioral, electrophysiological and neuroimaging sub-studies. The protocol includes techniques with minima...

Deep Brain Stimulation Surgery for Movement Disorders

Jun 24th, 2022 - Objective: The objective of this protocol is to provide standard of care DBS surgery and to collect prospective physiology data related to DBS therapy and motor and cognitive function in people with medically refractory Parkinson s disease (PD), d...

A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm

Jun 22nd, 2022 - The purpose of this study is to determine whether a single treatment with administration of NT 201 (botulinum toxin) is superior to placebo (no medicine) for one-sided treatment of essential tremor in the arm (Unilateral Period). Participants will...

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News  97 results

Genetic Variations Explain Essential Tremor Risk

Jan 13th, 2022 - Several common regions of DNA are linked to an increased risk of developing essential tremor (ET), new research shows. Investigators studied more than 480,000 adults and found five genetic loci that were significantly associated with ET risk, part...

Novel Drug Effective for Essential Tremor, but With Significant Side Effects

Sep 27th, 2021 - The investigational oral, neuroactive, steroid-positive allosteric modulator SAGE-324/BIIB124 (SAGE-324) is effective for treating essential tremor ― but problems with tolerability may limit its usefulness, new research suggests. The phase 2 KINET...

Low-Intensity Focused Ultrasound Safe, Effective in Mild Alzheimer's Disease

Aug 30th, 2021 - A new noninvasive procedure is safe and effective for treating patients with mild Alzheimer's disease (AD), new research suggests. Clinicians monitor a trial patient with AD undergoing low-intensity focused ultrasound. The approach uses MRI-guided...

Depression remains common among dystonia patients
Heidi Splete

Jun 22nd, 2021 - About one-third of individuals with adult-onset idiopathic dystonia experience major depression or dysthymia, data from a meta-analysis of 54 studies show. Adult-onset idiopathic dystonia (AOID) is the third-most common movement disorder after ess.

FDA Clears Next-Generation DBS System for Movement Disorders

Jun 8th, 2021 - The US Food and Drug Administration (FDA) has approved Medtronic's technologically advanced deep brain stimulation (DBS) system designed to more precisely target motor symptoms in Parkinson's disease, dystonia, or essential tremor. The SenSight Di...

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Patient Education  7 results see all →