×
About 610 results

ALLMedicine™ Friedreich Ataxia Center

Research & Reviews  230 results

The Responsiveness of Gait and Balance Outcomes to Disease Progression in Friedreich At...
https://doi.org/10.1007/s12311-021-01348-2
Cerebellum (London, England); Milne SC, Kim SH et. al.

Dec 3rd, 2021 - To identify gait and balance measures that are responsive to change during the timeline of a clinical trial in Friedreich ataxia (FRDA), we administered a battery of potential measures three times over a 12-month period. Sixty-one ambulant individ...

Mitochondrial iron-sulfur cluster biogenesis and neurological disorders.
https://doi.org/10.1016/j.mito.2021.10.004
Mitochondrion Selvanathan A, Parayil Sankaran B

Oct 24th, 2021 - Iron-sulfur clusters (ISCs) are highly conserved moieties embedded into numerous crucial proteins in almost all bacteria, plants and mammals. As such, ISC biosynthesis is critical to cellular function. The pathway was first characterized in bacter...

FA Clinical Outcome Measures
https://clinicaltrials.gov/ct2/show/NCT03090789

Oct 20th, 2021 - Friedreich's ataxia (FA) is a rare autosomal recessive degenerative disorder characterized by ataxia, dysarthria, sensory loss, diabetes and cardiomyopathy. The discovery of the abnormal gene in FA and its product (frataxin) has provided insight i...

Neuroinflammation in the Cerebellum and Brainstem in Friedreich Ataxia: An 18 F-FEMPA P...
https://doi.org/10.1002/mds.28825
Movement Disorders : Official Journal of the Movement Dis... Khan W, Corben LA et. al.

Oct 14th, 2021 - Neuroinflammation is proposed to accompany, or even contribute to, neuropathology in Friedreich ataxia (FRDA), with implications for disease treatment and tracking. To examine brain glial activation and systemic immune dysfunction in people with F...

see more →

Clinicaltrials.gov  12 results

FA Clinical Outcome Measures
https://clinicaltrials.gov/ct2/show/NCT03090789

Oct 20th, 2021 - Friedreich's ataxia (FA) is a rare autosomal recessive degenerative disorder characterized by ataxia, dysarthria, sensory loss, diabetes and cardiomyopathy. The discovery of the abnormal gene in FA and its product (frataxin) has provided insight i...

A Natural History Study to TRACK Brain and Spinal Cord Changes in Individuals With Friedreich Ataxia (TRACK-FA)
https://clinicaltrials.gov/ct2/show/NCT04349514

Oct 8th, 2021 - Friedreich ataxia (FA) is a multi-system progressive disorder with the most prevalent and prominent symptoms relating to dysfunction in the central and peripheral nervous system, including, loss of balance and coordination, frequent falls, loss of...

Efficacy, Tolerability, and Pharmacokinetics of Multiple Doses of Oral TAK-831 in Adults With Friedreich Ataxia
https://clinicaltrials.gov/ct2/show/NCT03214588

Jun 14th, 2021 - The drug being tested in this study is called TAK-831. TAK-831 is being tested to treat people who have Friedreich ataxia. This study will look at upper extremity (arms and hands) motor function and manual dexterity of people who take TAK-831. Eff...

Characterization of the Interruptions of the GAA Expansion and Study of Their Influence on the Severity of Friedreich's Ataxia
https://clinicaltrials.gov/ct2/show/NCT04346238

Apr 16th, 2020 - Friedreich's ataxia (FA) is the most frequent recessive genetic ataxia with an estimated prevalence of 1/50 000. The first symptoms appear around the age of 10 years with a progressive course and the need for an armchair 10- 15 years after the fir...

Efficacy of EGb761 in Patients Suffering From Friedreich Ataxia
https://clinicaltrials.gov/ct2/show/NCT00824512

Apr 7th, 2020 - The purpose of this protocol is to determine the efficacy of EGb 761 120 mg bid versus placebo in patients suffering from Friedreich Ataxia

see more →

News  2 results

Newer Methods May Boost Gene Therapy's Use for More Diseases
https://www.medscape.com/viewarticle/952299

Jun 2nd, 2021 - Jordan Janz knew his gamble on an experimental gene therapy for his rare disease might be paying off when he returned to work and a friend sniffed him. "He said, 'you have a normal smell, you smell good,'" Janz recalled. "And I'm like, 'that's pro...

Idebenone in Friedreich's Ataxia?
https://www.medscape.com/viewarticle/727161

Aug 25th, 2010 - A Phase 3, Double-blind, Placebo-Controlled Trial of Idebenone in Friedreich Ataxia Lynch DR, Perlman SL, Meier T Arch Neurol. 2010;67:941-947 Summary The goal of this randomized, double-blind, placebo-controlled intervention trial was to evaluate...

see more →