ALLMedicine™ Neurodegenerative Disorders Center

Mar 18th, 2023 - Mitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain mitochondria are the primary source of fuel that supports many brain functions, including intracellular energy supply, cellular calcium regulation, regulati...

Mar 17th, 2023 - Humans are thought to be more susceptible to neurodegeneration than equivalently-aged primates. It is not known whether this vulnerability is specific to anatomically-modern humans or shared with other hominids. The contribution of introgressed Ne...

Mar 17th, 2023 - TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises from the nucleus to the cytoplasm in a range of neurodegenerative disorders. TDP-43 proteinopathy spans a spectrum of incurable, heterogeneous, and increasi...

Mar 16th, 2023 - The synthesis and release of melatonin in the brain harmonize various physiological functions. The apparent decline in melatonin levels with advanced aging is an aperture to the neurodegenerative processes. It has been indicated that down regulati...

Mar 16th, 2023 - Choroid plexuses (ChPs) are intraventricular structures mainly composed by specialized epithelial cells interconnected by tight junctions that establish the blood-cerebrospinal fluid (CSF) barrier. ChPs are essential to produce CSF and transport s...

Jan 3rd, 2023 - High fructose corn syrup (HFCS) is a sweetener made from cornstarch. Corn sweeteners have several advantages over sugar, such as freshness, no color or flavor, and low price (1-3). Widespread use of the Western diet is believed to play an importan...

Jun 23rd, 2018 - Recommendations for using fluorodeoxyglucose positron emission tomography (FDG-PET) to support the diagnosis of dementing neurodegenerative disorders are sparse and poorly structured. Twenty-one questions on diagnostic issues and on semi-automated...

Mar 3rd, 2010 - Modifying the sleep environment is recommended for the treatment of patients with RBD who have sleep-related injury. Level A Clonazepam is suggested for the treatment of RBD but should be used with caution in patients with dementia, gait disorders...

Mar 10th, 2023 - Research goals include elucidation of the complex relationship between ALS and related neurodegenerative disorders, development of both wet and dry biomarkers of disease, and delineation of the full course of the natural history of disease from th...

Mar 10th, 2023 - Analysis of skin fibroblasts from normal, obese, lean/diabetic and obese/diabetic individuals and in vitro epigenetic conversion, as revealed by morphological changes, loss of mesenchymal markers and expression of pluripotency genes. To re-differe...

Mar 9th, 2023 - Glaucoma: a major health care challenge of the 21st century Glaucoma is a leading cause of irreversible blindness worldwide and is expected to affect 76 million people by the year 2020. In glaucoma, there is a permanent loss of retinal ganglion ce...

Mar 8th, 2023 - Parkinson's disease (PD), is one of the commonest neurodegenerative disorders with a severe progressive course and major impact on patients' quality of life. The development of late-onset PD likely results from the interaction of genetic and envir...

Mar 1st, 2023 - Approximately 40 subjects with Parkinson's Disease (PD) with REM Sleep Behavior Disorder (RBD) and Depressive Symptoms, Mild Cognitive Impairment (MCI) with Depressive Symptoms, Dementia with Lewy Bodies (DLB) with Cognitive Fluctuations, and Park...

Mar 13th, 2023 - Adults ages 40 to 69 with physical frailty or prefrailty were more likely to have subsequent Parkinson's disease, prospective data from the U.K. Biobank cohort showed. Over 12 years, frailty was tied to an 87% increased risk of Parkinson's compare...

Jan 30th, 2023 - At least 22 viral illnesses were linked with an increased risk of subsequent neurodegenerative disease, NIH researchers found. Using data from the U.K. and Finland, Mike Nalls, PhD, of the NIH Center for Alzheimer's and Related Dementias, and co-a...

Jan 23rd, 2023 - Head injuries decreased long-term survival time in a dose-dependent manner, longitudinal data showed. All-cause mortality was twice as high for adults who had sustained a head injury earlier in life (HR 1.99, 95% CI 1.88-2.11) compared with those ...

Jan 3rd, 2023 - High fructose corn syrup (HFCS) is a sweetener made from cornstarch. Corn sweeteners have several advantages over sugar, such as freshness, no color or flavor, and low price (1-3). Widespread use of the Western diet is believed to play an importan...

Dec 30th, 2022 - A novel blood test to assess brain-derived tau detected Alzheimer's-related neurodegeneration and differentiated Alzheimer's from other neurodegenerative diseases. The test outperformed total tau and, unlike neurofilament light, showed specificity...