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About 10,453 results

ALLMedicine™ Neurodegenerative Disorders Center

Research & Reviews  4,023 results

Mechanistic Target of Rapamycin Complex 1: From a Nutrient Sensor to a Key Regulator of...
https://doi.org/10.1093/advances/nmac055
Advances in Nutrition (Bethesda, Md.); Wang G, Chen L et. al.

May 14th, 2022 - Mechanistic target of rapamycin complex 1 (mTORC1) is a multi-protein complex widely found in eukaryotes. It serves as a central signaling node to coordinate cell growth and metabolism by sensing diverse extracellular and intracellular inputs, inc...

Genetic Studies of Lysosomal Storage Disorders
https://clinicaltrials.gov/ct2/show/NCT00001215

May 13th, 2022 - There is a vast spectrum of clinical manifestations encountered in individuals with lysosomal storage diseases. Lysosomal storage disorders occur when an enzyme necessary for breaking down intracellular fats, proteins, recycled products and organe...

Investigations of Juvenile Neuronal Ceroid Lipofuscinosis
https://clinicaltrials.gov/ct2/show/NCT03307304

May 13th, 2022 - Juvenile Neuronal Ceroid Lipofuscinosis (Batten Disease, CLN3) is a recessive, fatal, lysosomal storage disease that results in progressive neurodegeneration. In aggregate, the 13 disorders of neuronal ceroid lipofuscinosis are considered the most...

Crystal structure of human acetylcholinesterase in complex with tacrine: Implications f...
https://doi.org/10.1016/j.ijbiomac.2022.05.009
International Journal of Biological Macromolecules; Dileep KV, Ihara K et. al.

May 9th, 2022 - Alzheimer's disease (AD) is one of the most common, progressive neurodegenerative disorders affecting the aged populations. Though various disease pathologies have been suggested for AD, the impairment of the cholinergic system is one of the criti...

Cytoskeleton saga: Its regulation in normal physiology and modulation in neurodegenerat...
https://doi.org/10.1016/j.ejphar.2022.175001
European Journal of Pharmacology; Sen S, Lagas S et. al.

May 8th, 2022 - Cells are fundamental units of life. To ensure the maintenance of homeostasis, integrity of structural and functional counterparts is needed to be essentially balanced. The cytoskeleton plays a vital role in regulating the cellular morphology, sig...

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Guidelines  2 results

European Association of Nuclear Medicine and European Academy of Neurology recommendati...
https://doi.org/10.1111/ene.13728
European Journal of Neurology; Nobili F, Arbizu J et. al.

Jun 23rd, 2018 - Recommendations for using fluorodeoxyglucose positron emission tomography (FDG-PET) to support the diagnosis of dementing neurodegenerative disorders are sparse and poorly structured. Twenty-one questions on diagnostic issues and on semi-automated...

Best practice guide for the treatment of REM sleep behavior disorder (RBD).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823283
Journal of Clinical Sleep Medicine : JCSM : Official Publ... Aurora RN, Zak RS et. al.

Mar 3rd, 2010 - Modifying the sleep environment is recommended for the treatment of patients with RBD who have sleep-related injury. Level A Clonazepam is suggested for the treatment of RBD but should be used with caution in patients with dementia, gait disorders...

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Clinicaltrials.gov  54 results

Genetic Studies of Lysosomal Storage Disorders
https://clinicaltrials.gov/ct2/show/NCT00001215

May 13th, 2022 - There is a vast spectrum of clinical manifestations encountered in individuals with lysosomal storage diseases. Lysosomal storage disorders occur when an enzyme necessary for breaking down intracellular fats, proteins, recycled products and organe...

Investigations of Juvenile Neuronal Ceroid Lipofuscinosis
https://clinicaltrials.gov/ct2/show/NCT03307304

May 13th, 2022 - Juvenile Neuronal Ceroid Lipofuscinosis (Batten Disease, CLN3) is a recessive, fatal, lysosomal storage disease that results in progressive neurodegeneration. In aggregate, the 13 disorders of neuronal ceroid lipofuscinosis are considered the most...

Exploring the Effects of Spinal Cord Stimulation in Parkinson's Disease.
https://clinicaltrials.gov/ct2/show/NCT03526991

Apr 25th, 2022 - Freezing of gait (FOG) is a devastating motor phenomenon which may occur in patients with Parkinson's Disease (PD) and other neurodegenerative disorders. It is characterized by episodes during which patients cannot generate effective forward stepp...

Norepinephrine Transporter Blockade, Autonomic Failure (NETAF)
https://clinicaltrials.gov/ct2/show/NCT02784535

Apr 14th, 2022 - Autonomic failure is a group of rare neurodegenerative disorders that primarily affect the autonomic nervous system. These patients develop neurogenic orthostatic hypotension (OH) because of impaired autonomic reflexes that control cardiovascular ...

Norepinephrine Transporter Blockade, Autonomic Failure (NETAF)
https://clinicaltrials.gov/ct2/show/NCT02796209

Apr 14th, 2022 - Autonomic failure is a group of rare neurodegenerative disorders that primarily affect the autonomic nervous system. These patients develop neurogenic orthostatic hypotension (OH) because of impaired autonomic reflexes that control cardiovascular ...

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News  100 results

Nothing to Sniff At: Loss of Smell Linked With Increased Risk of Premature Death
https://www.medpagetoday.com/primarycare/generalprimarycare/98102

Apr 7th, 2022 - Olfactory impairment, or loss of smell, significantly increased the likelihood of early death versus people with a normal sense of smell, a literature review and meta-analysis showed. The analysis of 21,600 patients yielded a pooled mortality haza...

Low-Intensity Focused Ultrasound Safe, Effective in Mild Alzheimer's Disease
https://www.medscape.com/viewarticle/957487

Aug 30th, 2021 - A new noninvasive procedure is safe and effective for treating patients with mild Alzheimer's disease (AD), new research suggests. Clinicians monitor a trial patient with AD undergoing low-intensity focused ultrasound. The approach uses MRI-guided...

Managing Sleep Problems in Older Adults
https://www.medscape.com/viewarticle/956974

Aug 20th, 2021 - Sleep problems are prevalent in older adults, and overmedication is a common cause. Insomnia is a concern, and it might not look the same in older adults as it does in younger populations, especially when neurodegenerative disorders may be present...

Early Motor Signal Specific to Alzheimer's Identified
https://www.medscape.com/viewarticle/946453

Feb 25th, 2021 - Abnormal walking patterns may be an early indicator of dementia caused by Alzheimer's disease (AD) and may distinguish it from other neurodegenerative and cognitive disorders, new research suggests. Results of a new study show that a high degree o...

Alzheimer's Blood Test Predicts Pathology
https://www.medpagetoday.com/neurology/alzheimersdisease/90555

Jan 6th, 2021 - This story was published originally on May 4, 2020. As part of MedPage Today's review of stories in the past year, we're republishing it, along with an update on further developments in blood tests for Alzheimer's disease. An ultrasensitive blood ...

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Patient Education  2 results see all →