About 9,495 results

ALLMedicine™ Parkinson Disease Center

Research & Reviews  3,457 results

Asparagine endopeptidase deletion ameliorates cognitive impairments by inhibiting proin...
Brain Research Bulletin; Gao J, Zhang W et. al.

Nov 29th, 2021 - In addition to motor dysfunction, cognitive impairments have been reported to occur in patients with early-stage Parkinson's disease (PD). In this study, we examined a PD mouse model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). ...

Characterizing mild cognitive impairment in prodromal Parkinson's disease: A community-...
CNS Neuroscience & Therapeutics; Pan C, Li Y et. al.

Nov 26th, 2021 - The International Parkinson and Movement Disorder Society (MDS) has published research criteria for prodromal Parkinson's disease (pPD), which includes cognitive impairment as a prodromal marker. However, the clinical features of mild cognitive im...

Daily Phonatory Activity of Individuals With Parkinson's Disease.
Journal of Voice : Official Journal of the Voice Foundation; Searl J, Dietsch AM

Nov 26th, 2021 - This study evaluated the amount of phonatory activity of Persons with Parkinson disease (PwPD) compared to adults without Parkinson's disease measured over 3 days. The relationship between the amount of phonatory activity and Voice Handicap Index ...

The PINK1 advantage: recycling mitochondria in times of trouble?
Autophagy Doric Z, Li H et. al.

Nov 24th, 2021 - Parkinson disease remains a debilitating neurodegenerative disorder, despite the discovery of multiple causative genes that account for familial forms. Prominent among these are PRKN/Parkin and PINK1, whose protein products participate in mitochon...

The effect of a multi-modal boxing exercise program on cognitive locomotor tasks and ga...
NeuroRehabilitation Shearin S, Braitsch M et. al.

Nov 23rd, 2021 - Parkinson disease (PD) is a progressive neurological disease resulting in motor impairments, postural instability, and gait alterations which may result in self-care limitations and loss of mobility reducing quality of life. This study's purpose w...

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Drugs  7 results see all →

Clinicaltrials.gov  131 results

The PACE-DLB Study

Nov 23rd, 2021 - Dementia with Lewy bodies (DLB) is part of Lewy body dementia, the 2nd-most-common degenerative dementia in the U.S. It is also one of the Alzheimer's disease-related dementias (ADRDs). Evidence-based models of end-of-life care for ADRDs are insuf...

Validity and Reliability of VO2-max Measurements in Persons With Parkinson's Disease

Nov 19th, 2021 - Each participant would complete four test days and each test day is separated by 7-10 days. At each test day the participants would complete a graded maximal exercise test (VO2max-test), a chair rise (Linear encoder) as well as measuring of basic ...

Subthalamic Nucleus Stimulation With Directional Leads on Patients With Parkinson Disease at Fluctuations and Dyskinesia Stage

Nov 2nd, 2021 - Patients with subthalamic nucleus have to go through a lot of examinations and tests, before and after surgery which is difficult, sometimes painful, for the patient. The investigators used to chose the best plot of the leads for stimulation by a ...

Dual Task and Virtuality Training Innovation to Improve Balance, Posture and Gait in Patients With Parkinson Disease

Oct 1st, 2021 - Introduction Parkinson disease (PD) is a neurodegenerative disease of the brain, leads to degeneration and causing the motor and non-motor symptoms. PD is characterized by dopaminergic neurotransmitter deficiency. It is a progressive neurological ...

Improvisational Movement for People With Memory Loss and Their Caregivers

Sep 30th, 2021 - Dementia is a progressive decline in cognition that impairs a person's ability to perform activities of daily living. Alzheimer's disease is the most common form of dementia, the most common neurodegenerative disease in older adults, and the 6th l...

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News  201 results

Sublingual Film Well-Tolerated for Parkinson 'Off' Episodes

Sep 19th, 2021 - A majority of patients with Parkinson disease (PD) experiencing "off" episodes  successfully tolerated titration to an effective and tolerable dose of sublingual apomorphine film (SL-apo; Kynmobi, Sunovion Pharmaceuticals) without the use of antie...

Antioxidant Therapy Tested in Early Parkinson’s

Sep 14th, 2021 - Treatment with the urate precursor inosine did not result in a significant difference in the rate of clinical disease progression in early Parkinson's disease, the phase III SURE-PD3 trial showed. Clinical progression rates, measured by the Moveme...

General or Local Anesthesia for Deep Brain Stimulation Surgery: Which Is Best?

Sep 14th, 2021 - The outcome of deep brain stimulation (DBS) surgery for Parkinson disease (PD) is comparable when performed under general or local anesthesia, results of a new randomized trial show. Investigators note that postoperative confusion frequently occur...

Recognizing and Treating Unexpected OFF Episodes in Parkinson Disease

Apr 29th, 2021 - In this supplement to Neurology Reviews, the authors provide a general overview of the OFF state, including unexpected OFF; cover the importance of distinguishing unexpected OFF from other OFF states before deciding on treatment options; explain h.

Long-term Benefit for DBS in Treating Parkinson's Motor Symptoms

Apr 22nd, 2021 - Deep brain stimulation (DBS) significantly improves motor function in patients with Parkinson's disease (PD) over the long term regardless of the therapeutic target, new research shows. In the longest follow-up study comparing the subthalamic nucl...

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Patient Education  2 results see all →