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ALLMedicine™ Progressive Supranuclear Palsy Center

Research & Reviews  955 results

Prediagnostic Progressive Supranuclear Palsy - Insights from the UK Biobank.
https://doi.org/10.1016/j.parkreldis.2022.01.004
Parkinsonism & Related Disorders; Street D, Whiteside D et. al.

Jan 16th, 2022 - Prediagnostic features of Parkinson's Disease are well described but prediagnostic Progressive Supranuclear Palsy (PSP) is less understood. The diagnosis of PSP is delayed by an average of three years after symptom onset. Understanding the changes...

Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of P...
https://doi.org/10.1097/RLU.0000000000003974
Clinical Nuclear Medicine; Jia C, Wu M et. al.

Jan 13th, 2022 - A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations ...

Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders
https://clinicaltrials.gov/ct2/show/NCT03299062

Jan 12th, 2022 - Degenerative dementias including Alzheimer's Disease (AD), Parkinson's Disease with Dementia (PDD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementias (FTLD), Corticobasal Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) constitu...

Role of Apolipoprotein E in the Clinical Profile of Atypical Parkinsonian Syndromes.
https://doi.org/10.1097/WAD.0000000000000479
Alzheimer Disease and Associated Disorders; Nasri A, Sghaier I et. al.

Jan 11th, 2022 - Atypical Parkinsonian syndromes (APS) encompass a spectrum of neurodegenerative diseases including dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal syndrome (CBS). The effects o...

A Phase 2a Study of TPN-101 in Patients With Progressive Supranuclear Palsy (PSP)
https://clinicaltrials.gov/ct2/show/NCT04993768

Jan 11th, 2022 - This is a Phase 2a multi-center, randomized, double-blind, placebo-controlled parallel-group, 4-arm study with an open-label treatment phase in patients with PSP. This study includes a 6-week Screening Period, a 24-week Double-blind Treatment Peri...

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Drugs  1 results see all →

Clinicaltrials.gov  45 results

Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders
https://clinicaltrials.gov/ct2/show/NCT03299062

Jan 12th, 2022 - Degenerative dementias including Alzheimer's Disease (AD), Parkinson's Disease with Dementia (PDD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementias (FTLD), Corticobasal Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) constitu...

A Phase 2a Study of TPN-101 in Patients With Progressive Supranuclear Palsy (PSP)
https://clinicaltrials.gov/ct2/show/NCT04993768

Jan 11th, 2022 - This is a Phase 2a multi-center, randomized, double-blind, placebo-controlled parallel-group, 4-arm study with an open-label treatment phase in patients with PSP. This study includes a 6-week Screening Period, a 24-week Double-blind Treatment Peri...

A Study to Assess Tolerability, Safety, Pharmacokinetics and Effect of AZP2006 in Patients With PSP
https://clinicaltrials.gov/ct2/show/NCT04008355

Dec 21st, 2021 - A phase 2 study to assess tolerability, safety, pharmacokinetics and effect of AZP2006 at different doses versus placebo on cerebrospinal fluid biomarkers in 36 patients with progressive supranuclear palsy. The patient study duration is 29 weeks i...

New Biomarkers in Parkinson's Disease
https://clinicaltrials.gov/ct2/show/NCT05150158

Dec 8th, 2021 - Much evidence suggests the existence of a preclinical stage of disease that begins many years before PD is diagnosed, when an individual appears normal (there are no symptoms or signs), but is already developing typical neuropathological changes. ...

Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
https://clinicaltrials.gov/ct2/show/NCT01818661

Nov 8th, 2021 - Apraxia of Speech (AOS) is a disorder of speech motor planning and/or programming that affects the production of speech, characterized by slow speaking rate, abnormal prosody and distorted sound substitutions, additions, repetitions and prolongati...

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News  41 results

Blood Test Discerns Alzheimer's From Other Dementia With High Accuracy
https://www.medpagetoday.com/neurology/alzheimersdisease/94177

Aug 23rd, 2021 - Two blood markers, phosphorylated tau 217 (p-tau217) and phosphorylated tau 181 (p-tau181), showed strong diagnostic performances for Alzheimer's disease and discriminated Alzheimer's from frontotemporal lobar denervation (FTLD) syndromes and norm...

Alzheimer's Blood Test Predicts Pathology
https://www.medpagetoday.com/neurology/alzheimersdisease/90555

Jan 6th, 2021 - This story was published originally on May 4, 2020. As part of MedPage Today's review of stories in the past year, we're republishing it, along with an update on further developments in blood tests for Alzheimer's disease. An ultrasensitive blood ...

Negative Phase 2 Trial Data Ends Development of PSP Drug
https://www.medscape.com/viewarticle/922592

Dec 13th, 2019 - Topline results from the phase two PASSPORT trial show the experimental drug gosuranemab (BIIB092, Biogen) did not meet its primary or key secondary endpoints in patients with the atypical parkinsonian disorder of progressive supranuclear palsy (P...

The Falls and Frustrations of Progressive Supranuclear Palsy
https://www.medscape.com/viewarticle/921622

Nov 25th, 2019 - I often repeat her presentation to medical students: my only patient ever to fall walking into a clinic visit had progressive supranuclear palsy (PSP). Her impaired postural reflexes were no match for a set of brick steps. Perhaps she didn't notic...

Review Into One-Size-Fits-All NHS Health Checks
https://www.medscape.com/viewarticle/916916

Aug 16th, 2019 - A review into the effectiveness of NHS health checks, improvements to care for people with neurological conditions, and guidance by NICE on a breast cancer drug, featured in announcements this week. NHS Health Checks An evidence-based review into ...

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Patient Education  10 results see all →