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ALLMedicine™ Cryptococcosis Center

Research & Reviews  561 results

An in vitro method for inducing titan cells reveals novel features of yeast-to-titan sw...
https://doi.org/10.1371/journal.ppat.1010321
PLoS Pathogens; Saidykhan L, Correia J et. al.

Aug 16th, 2022 - Cryptococcosis is a potentially lethal fungal infection of humans caused by organisms within the Cryptococcus neoformans/gattii species complex. Whilst C. neoformans is a relatively common pathogen of immunocompromised individuals, C. gattii is ca...

Pulmonary cryptococcosis after recovery from COVID-19 in an immunocompetent patient: A ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370245
Medicine Choi HS

Aug 13th, 2022 - Cryptococcus neoformans (C neoformans) infection typically occurs in immunocompromised patients infected with human immunodeficiency virus (HIV), or those taking immunosuppressive drugs, corticosteroids, or chemotherapy. Recently, there have been ...

Cryptococcal antigen screening and missed opportunities for earlier diagnosis among peo...
https://doi.org/10.1097/QAI.0000000000003074
Journal of Acquired Immune Deficiency Syndromes (1999); Yoon H, Hemmige VS et. al.

Aug 12th, 2022 - There is no established cryptococcal antigen (CrAg) screening guideline for people with HIV who are antiretroviral therapy-experienced but have poor virologic control. We assessed factors associated with CrAg screening and describe missed opportun...

Cryptococcus gattii Infection as the Major Clinical Manifestation in Patients with Auto...
https://doi.org/10.1007/s10875-022-01341-2
Journal of Clinical Immunology; Wang SY, Lo YF et. al.

Aug 11th, 2022 - Anti-granulocyte-macrophage colony-stimulating factor autoantibodies (anti-GM-CSF Abs) are a predisposing factor for pulmonary alveolar proteinosis (PAP) and Cryptococcus gattii cryptococcosis. This study aimed to investigate clinical manifestatio...

Calcimycin Inhibits Cryptococcus neoformans In Vitro and In Vivo by Targeting the Prp8 ...
https://doi.org/10.1021/acsinfecdis.2c00137
ACS Infectious Diseases; Tharappel AM, Li Z et. al.

Aug 11th, 2022 - Drug resistance is a significant concern in the treatment of diseases, including cryptococcosis caused by Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga). Alternative drug targets are necessary to overcome drug resistance before it att...

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Drugs  17 results see all →

Clinicaltrials.gov  14 results

Cryptococcosis in Previously Healthy Adults
https://clinicaltrials.gov/ct2/show/NCT00001352

Aug 4th, 2022 - Cryptococcus is a fungus that causes infections most commonly in immunocompromised patients, such as those with AIDS and solid organ transplant recipients, particularly renal transplant recipients (1-3). However, approximately one-third of cases f...

An Enhanced Package of Care to Reduce Reduce Mortality in Advanced HIV Disease
https://clinicaltrials.gov/ct2/show/NCT05085171

Jul 12th, 2022 - The study will be carried out in a population of HIV-infected adults with advanced HIV disease (CD4 <200 cells/µL) in Uganda. It will be a Randomized controlled trial, Phase III in Uganda over a duration of 5 years assessing 24 weeks survival with...

Making an Early Diagnosis of Talaromycosis Using a Novel Antigen Test
https://clinicaltrials.gov/ct2/show/NCT04033120

Mar 4th, 2022 - This study aims to determine the diagnostic and prognostic values and the clinical impact of Talaromyces marneffei antigenemia (TmAg) in patients with advanced HIV disease using a novel enzyme immunoassay (EIA) detecting Tm-specific cell wall mann...

Comprehensive Diagnosis and Treatment Strategy for Opportunistic Fungal Infections in AIDS Patients
https://clinicaltrials.gov/ct2/show/NCT05153005

Dec 13th, 2021 - The research involves AIDS patients complicated with talaromycosis, PCP and cryptococcosis in the study. The main contents: To explore early screening and diagnostic strategies. To advance the application of taloromyces marneffeispecific mannose p...

Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG...
https://clinicaltrials.gov/ct2/show/NCT00000676

Nov 2nd, 2021 - Serious fungal infections are significant complicating and life-threatening occurrences in patients with advanced HIV infection. Oropharyngeal candidiasis is found in almost all such patients, and causes pain, difficulty in swallowing, and loss of...

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News  34 results

Multiple Crusted Swellings on the Chin
https://www.mdedge.com/dermatology/article/240890/mixed-topics/multiple-crusted-swellings-chin
Yashdeep Singh Pathania, MD, Gurwinder Kaur, MD

Jun 1st, 2021 - The Diagnosis: Cutaneous Cryptococcosis Histologic examination revealed infiltration of the dermis and subcutaneous tissue with rounded basophilic cells on low magnification (Figure 1A). On higher magnification, encapsulated yeast cells (cryptococ.

Cutaneous Manifestations of Nutritional Excess: Pathophysiologic Effects of Hyperglycemia and Hyperinsulinemia on the Skin
https://www.mdedge.com/dermatology/article/235460/mixed-topics/cutaneous-manifestations-nutritional-excess-pathophysiologic
Steven A. Svoboda, BS, Bridget E. Shields, MD

Feb 3rd, 2021 - Nutritional dermatoses are classically associated with dietary nutrient deficiencies; however, cutaneous disease as a consequence of nutrient excess often is overlooked. Chronic hyperglycemia and hyperinsulinemia resulting from excess carbohydrate.

Anti-ICOS Antibody MEDI-570 Elicits Durable Responses in Relapsed/Refractory T-cell Lymphomas
https://www.onclive.com/view/anti-icos-antibody-medi-570-elicits-durable-responses-in-relapsed-refractory-t-cell-lymphomas

Dec 20th, 2020 - The anti-inducible T-cell co-stimulator (ICOS) monoclonal antibody MEDI-570 showed clinical activity with durable responses, as well as acceptable safety and tolerability in patients with relapsed/refractory angioimmunoblastic T-cell lymphoma (AIT...

Umbilicated Neoplasm on the Chest
https://www.mdedge.com/dermatology/article/232349/contact-dermatitis/umbilicated-neoplasm-chest
Bo Li, MD, Xiangqian Li, MD et. al.

Nov 23rd, 2020 - Dermoscopy showed polylobular, whitish yellow, amorphous structures at the center of the lesion surrounded by a crown of vessels (Figure 1). Histopathology revealed hyperplastic crateriform lesions containing large eosinophilic intracytoplasmic in.

Primary Cutaneous Cryptococcosis in an Immunocompetent Iraq War Veteran
https://www.mdedge.com/dermatology/article/190835/infectious-diseases/primary-cutaneous-cryptococcosis-immunocompetent-iraq?channel=44
James V. Twede, MD, Kristopher M. Peters, DO

Dec 10th, 2018 - To the Editor: Disseminated cryptococcosis is a well-known opportunistic infection in patients with advanced human immunodeficiency virus (HIV) infection, but it is not frequently seen as a primary infection of the skin in immunocompetent hosts. W.

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