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About 500 results

ALLMedicine™ Venezuelan Equine Encephalitis Center

Research & Reviews  190 results

Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to a...
https://doi.org/10.1371/journal.ppat.1009946
PLoS Pathogens; Ma H, Albe JR et. al.

Jun 14th, 2022 - Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus macaques are a relevant model of the human disease caused by VEEV and are useful in exploring...

Safety and immunogenicity of a trivalent virus-like particle vaccine against western, e...
https://doi.org/10.1016/S1473-3099(22)00052-4
The Lancet. Infectious Diseases; Coates EE, Edupuganti S et. al.

May 15th, 2022 - Western (WEEV), eastern (EEEV), and Venezuelan (VEEV) equine encephalitis viruses are mosquito-borne pathogens classified as potential biological warfare agents for which there are currently no approved human vaccines or therapies. We aimed to eva...

Evaluating sampling strategies for enzootic Venezuelan equine encephalitis virus vector...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007344
PLoS Neglected Tropical Diseases; Sloyer KE, Santos M et. al.

Apr 14th, 2022 - Determining effective sampling methods for mosquitoes are among the first objectives in elucidating transmission cycles of vector-borne zoonotic disease, as the effectiveness of sampling methods can differ based on species, location, and physiolog...

Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essentia...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093095
Journal of Virology; Lucas CJ, Davenport BJ et. al.

Apr 14th, 2022 - Alphaviruses infect cells by a low pH-dependent fusion reaction between viral and host cell membranes that is mediated by the viral E1 glycoprotein. Most reported alphavirus E1 sequences include two phenylalanines (F87 and F95) in the fusion loop,...

Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aeros...
https://doi.org/10.1084/jem.20212532
The Journal of Experimental Medicine; Kafai NM, Williamson LE et. al.

Mar 18th, 2022 - Venezuelan equine encephalitis virus (VEEV) remains a risk for epidemic emergence or use as an aerosolized bioweapon. To develop possible countermeasures, we isolated VEEV-specific neutralizing monoclonal antibodies (mAbs) from mice and a human im...

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Clinicaltrials.gov  6 results

Venezuelan Equine Encephalitis Monovalent Virus-Like Particle Vaccine
https://clinicaltrials.gov/ct2/show/NCT03776994

Feb 23rd, 2021 - This Phase 1 dose escalation study will evaluate safety and immunogenicity of both non-adjuvanted and adjuvanted VEE VLP vaccine in three dose groups (2 μg, 10 μg, and 20 μg) given as a 2-dose primary series IM injection (Days 0 and Week 4 [Day 28...

Effectiveness of Ivermectin in SARS-CoV-2/COVID-19 Patients
https://clinicaltrials.gov/ct2/show/NCT04739410

Feb 4th, 2021 - The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019. In the first half of 2020 this disease has already converted into a global pandemic, having different forms of pr...

Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus Vaccine
https://clinicaltrials.gov/ct2/show/NCT00109304

Sep 18th, 2015 - Safety Objectives: 1) To determine preliminary safety, reactogenicity, and tolerability of VEE IA/B V3526 in VEE-naïve healthy volunteers after single dose subcutaneous (SC) administration; 2) To evaluate virological safety by assessing serum vire...

Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy Volunteers
https://clinicaltrials.gov/ct2/show/NCT01984983

Aug 26th, 2015 - The Phase I study will assess the basic safety, tolerability, and immunogenicity of a DNA-based Venezuelan equine encephalitis virus (VEEV)vaccine candidate delivered by electroporation . The study will enroll 40 healthy adult volunteers ages 18-4...

Safety of and Immune Response to an HIV-1 Subtype C Vaccine (AVX101) in HIV Uninfected Adults
https://clinicaltrials.gov/ct2/show/NCT00097838

Jul 2nd, 2012 - HIV-1 subtype C is the prevailing subtype of HIV found in sub-Saharan Africa and is primarily responsible for the HIV/AIDS epidemic in southern Africa. Thus, development of a preventive subtype C vaccine is critically important in controlling the ...

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News  4 results

Encephalitis: 2010 Outbreak in Panama Raises Concern
https://www.medscape.com/viewarticle/809754

Aug 21st, 2013 - Although a few cases of eastern equine encephalitis (EEE) in humans are reported each year in North America, the infection has been extremely rare in Latin America until 2010. In a report published online August 21 in the New England Journal of Me...

Encephalitis: 2010 Outbreak in Panama Raises Concern
https://www.staging.medscape.com/viewarticle/809754

Aug 21st, 2013 - Although a few cases of eastern equine encephalitis (EEE) in humans are reported each year in North America, the infection has been extremely rare in Latin America until 2010. In a report published online August 21 in the New England Journal of Me...

Evaluation in Nonhuman Primates of Vaccines against Ebola Virus
https://www.medscape.com/viewarticle/432519

Abstract and Introduction Ebola virus (EBOV) causes acute hemorrhagic fever that is fatal in up to 90% of cases in both humans and nonhuman primates. No vaccines or treatments are available for human use. We evaluated the effects in nonhuman prima...

Evaluation in Nonhuman Primates of Vaccines against Ebola Virus
https://www.medscape.com/viewarticle/432519_1

Abstract and Introduction Ebola virus (EBOV) causes acute hemorrhagic fever that is fatal in up to 90% of cases in both humans and nonhuman primates. No vaccines or treatments are available for human use. We evaluated the effects in nonhuman prima...

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