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About 33,012 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  16,037 results

A case of juvenile-onset amyotrophic lateral sclerosis with a de novo frameshift FUS ge...
https://doi.org/10.1080/21678421.2021.1927100
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; Wu Y, Li C et. al.

Jun 2nd, 2021 - Fused in sarcoma (FUS) is the most common causative gene in juvenile-onset amyotrophic lateral sclerosis (jALS). We presented a case of a 15-year-old Chinese girl with atypical and extremely rare bilateral abducens palsy was caused by a heterozygo...

ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-in...
https://doi.org/10.1073/pnas.2024605118
Proceedings of the National Academy of Sciences of the Un... Schmidt EJ, Funes S et. al.

Jun 2nd, 2021 - Profilin-1 (PFN1) plays important roles in modulating actin dynamics through binding both monomeric actin and proteins enriched with polyproline motifs. Mutations in PFN1 have been linked to the neurodegenerative disease amyotrophic lateral sclero...

Relative Effects of Forced Vital Capacity and ALSFRS-R on Survival in ALS.
https://doi.org/10.1002/mus.27344
Muscle & Nerve; Daghlas SA, Govindarajan R et. al.

Jun 2nd, 2021 - Amyotrophic lateral sclerosis (ALS) is a degenerative neuromuscular disease with marked clinical heterogeneity. This heterogeneity can be partly captured by clinical measures such as the forced vital capacity (FVC) and ALS Functional Rating Scale-...

ALS Patient and Caregiver Attitudes Toward Physician-Hastened Death in California.
https://doi.org/10.1002/mus.27343
Muscle & Nerve; Hauswirth AG, George HC et. al.

Jun 2nd, 2021 - Since 2016, six states have legalized physician-hastened death (PHD). Neuromuscular disorders including amyotrophic lateral sclerosis (ALS) are common diagnoses for patients who utilize PHD, but how patients with ALS view PHD in California has not...

Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the ...
https://doi.org/10.1002/mus.27339
Muscle & Nerve; Milligan C, Atassi N et. al.

Jun 2nd, 2021 - We tested safety, tolerability, and target engagement of tocilizumab in amyotrophic lateral sclerosis (ALS) patients. Twenty-two participants, whose peripheral blood mononuclear cell (PBMC) gene expression profile reflected high messenger ribonucl...

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Guidelines  9 results

Aquestive Therapeutics Receives FDA Approval for Exservan (riluzole) Oral Film
http://aquestive.com/aquestive-therapeutics-receives-fda-approval-for-exservan-riluzole-oral-film/

Nov 24th, 2019 - Aquestive Therapeutics, Inc. (NASDAQ: AQST), a specialty pharmaceutical company focused on developing and commercializing differentiated products to solve therapeutic problems, today announced that Exservan™ (riluzole) Oral Film received early-act...

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 8th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

MDA U.S. Neuromuscular Disease Registry
https://www.mda.org/services/neuromuscular-disease-registry
Muscular Dystrophy Association (USA)

Dec 31st, 2015 - In 2013, MDA launched the U. S.

EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--rev...
https://doi.org/10.1111/j.1468-1331.2011.03501.x
European Journal of Neurology; , Andersen PM et. al.

Sep 14th, 2011 - The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak. To provide evidence-based or expert recommendations for the diagnosis and management of ALS based on a literature search and the consensus of an exp...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 13th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  33 results see all →

Clinicaltrials.gov  16,453 results

Scientists Discover New Genetic Form of ALS in 11 Children
https://www.medscape.com/viewarticle/952489

Jun 6th, 2021 - (Reuters Health) - Scientists have identified four specific, dominant variants of the SPTLC1 gene in 11 children from seven different families who appear to have a new and unique form of amyotrophic lateral sclerosis (ALS). The findings suggest th...

A case of juvenile-onset amyotrophic lateral sclerosis with a de novo frameshift FUS ge...
https://doi.org/10.1080/21678421.2021.1927100
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; Wu Y, Li C et. al.

Jun 2nd, 2021 - Fused in sarcoma (FUS) is the most common causative gene in juvenile-onset amyotrophic lateral sclerosis (jALS). We presented a case of a 15-year-old Chinese girl with atypical and extremely rare bilateral abducens palsy was caused by a heterozygo...

ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-in...
https://doi.org/10.1073/pnas.2024605118
Proceedings of the National Academy of Sciences of the Un... Schmidt EJ, Funes S et. al.

Jun 2nd, 2021 - Profilin-1 (PFN1) plays important roles in modulating actin dynamics through binding both monomeric actin and proteins enriched with polyproline motifs. Mutations in PFN1 have been linked to the neurodegenerative disease amyotrophic lateral sclero...

Relative Effects of Forced Vital Capacity and ALSFRS-R on Survival in ALS.
https://doi.org/10.1002/mus.27344
Muscle & Nerve; Daghlas SA, Govindarajan R et. al.

Jun 2nd, 2021 - Amyotrophic lateral sclerosis (ALS) is a degenerative neuromuscular disease with marked clinical heterogeneity. This heterogeneity can be partly captured by clinical measures such as the forced vital capacity (FVC) and ALS Functional Rating Scale-...

ALS Patient and Caregiver Attitudes Toward Physician-Hastened Death in California.
https://doi.org/10.1002/mus.27343
Muscle & Nerve; Hauswirth AG, George HC et. al.

Jun 2nd, 2021 - Since 2016, six states have legalized physician-hastened death (PHD). Neuromuscular disorders including amyotrophic lateral sclerosis (ALS) are common diagnoses for patients who utilize PHD, but how patients with ALS view PHD in California has not...

see more →

News  461 results

Scientists Discover New Genetic Form of ALS in 11 Children
https://www.medscape.com/viewarticle/952489

Jun 6th, 2021 - (Reuters Health) - Scientists have identified four specific, dominant variants of the SPTLC1 gene in 11 children from seven different families who appear to have a new and unique form of amyotrophic lateral sclerosis (ALS). The findings suggest th...

Twofold Increased ALS Risk in Manual Laborers
https://www.medscape.com/viewarticle/949580

Apr 19th, 2021 - Blue-collar workers, particularly carpenters and construction workers, have a significantly increased risk for amyotrophic lateral sclerosis (ALS) compared with white-collar workers, new research shows. Investigators found manual laborers had a tw...

Theatrics, Hypnosis, and the Roots of Modern Neurology
https://www.medscape.com/viewarticle/947504

Mar 14th, 2021 - "Symptoms, then, are in reality nothing but a cry from suffering organs" – Jean-Martin Charcot Nearly 130 years after his death, Jean-Martin Charcot's name still resonates with modern neurologists. The famed 19th century French physician made myri...

New Compound Promising for ALS, Other Upper Motor Neuron Diseases
https://www.medscape.com/viewarticle/947056

Mar 10th, 2021 - NEW YORK (Reuters Health) - A new compound, NU-9, improved diseased upper motor neurons (UMN) in mice and shows promise for treating amyotrophic lateral sclerosis (ALS) in humans, though more work is needed before a clinical trial can be started, ...

After a Decade of Lobbying, ALS Patients Gain Faster Access to Disability Payments
https://www.medscape.com/viewarticle/944474

Jan 20th, 2021 - Anita Baron first noticed something was wrong in August 2018, when she began to drool. Her dentist chalked it up to a problem with her jaw. Then her speech became slurred. She managed to keep her company, which offers financing to small businesses...

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Patient Education  19 results see all →