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About 16,253 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  5,973 results

Genetic testing in motor neurone disease.
https://doi.org/10.1136/practneurol-2021-002989
Practical Neurology; Dharmadasa T, Scaber J et. al.

Jan 15th, 2022 - A minority (10%-15%) of cases of amyotrophic lateral sclerosis (ALS), the most common form of motor neurone disease (MND), are currently attributable to pathological variants in a single identifiable gene. With the emergence of new therapies targe...

The Cyanotoxin 2,4-DAB Reduces Viability and Causes Behavioral and Molecular Dysfunctio...
https://doi.org/10.1007/s12640-021-00465-4
Neurotoxicity Research; Martin RM, Bereman MS et. al.

Jan 15th, 2022 - Exposure to cyanotoxins has been linked to neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's, and Parkinson's disease. While the cyanotoxin β-methylamino-L-alanine (BMAA) has received much attention, cyanobacteria pr...

A Study of BIIB067 When Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation
https://clinicaltrials.gov/ct2/show/NCT04856982

Jan 14th, 2022 - The primary objective of this study is to evaluate the efficacy of BIIB067 when initiated in presymptomatic adult carriers of a superoxide dismutase 1 (SOD1) mutation with elevated neurofilament (NF). The secondary objectives of this study are to ...

Fat-rich versus carbohydrate-rich nutrition in ALS: a randomised controlled study.
https://doi.org/10.1136/jnnp-2021-328331
Journal of Neurology, Neurosurgery, and Psychiatry; Dorst J, Doenz J et. al.

Jan 14th, 2022 - There is growing evidence that the course of amyotrophic lateral sclerosis (ALS) may be influenced beneficially by applying high-caloric food supplements (HCSs). However, it is unknown which composition of nutrients offers optimal tolerability and...

Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model.
https://doi.org/10.1186/s12974-022-02380-7
Journal of Neuroinflammation; Xue YC, Liu H et. al.

Jan 14th, 2022 - Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neuron system associated with both genetic and environmental risk factors. Infection with enteroviruses, including poliovirus and coxsackievirus, such as coxsack...

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Guidelines  3 results

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 9th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

ESPEN guideline clinical nutrition in neurology.
https://doi.org/10.1016/j.clnu.2017.09.003
Clinical Nutrition (Edinburgh, Scotland); Burgos R, Bretón I et. al.

Dec 25th, 2017 - Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 14th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  17 results see all →

Clinicaltrials.gov  184 results

A Study of BIIB067 When Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation
https://clinicaltrials.gov/ct2/show/NCT04856982

Jan 14th, 2022 - The primary objective of this study is to evaluate the efficacy of BIIB067 when initiated in presymptomatic adult carriers of a superoxide dismutase 1 (SOD1) mutation with elevated neurofilament (NF). The secondary objectives of this study are to ...

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT02437110

Jan 13th, 2022 - Objective: In this Phase I, proof-of-concept study, we aim to determine whether an antiretroviral regimen approved to treat human immunodeficiency virus (HIV) infection would also suppress levels of Human Endogenous Retrovirus-K (HERV-K) found to ...

Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS
https://clinicaltrials.gov/ct2/show/NCT04569084

Jan 12th, 2022 - To evaluate and compare the efficacy of two dosing regimens of oral edaravone in subjects with amyotrophic lateral sclerosis (ALS) based on the change in ALS Functional Rating Scale- Revised (ALSFRS-R) score from baseline up to Week 48:

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT05178810

Jan 5th, 2022 - Multicenter, multinational, double-blind, randomized (2:1), placebo-controlled Phase III study to investigate the efficacy and safety of 100 mg FAB122 once daily as oral formulation in ALS patients.

Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing
https://clinicaltrials.gov/ct2/show/NCT04394871

Dec 16th, 2021 - Objective: Amyotrophic lateral sclerosis type 4 (ALS4) is an inherited form of motor neuron disease caused by mutation in the senataxin (SETX) gene. The main goal of this study will be to collect clinical and molecular biomarkers from patients wit...

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News  313 results

Long NFL Careers Significantly Boost ALS Risk, but What's at Play?
https://www.medscape.com/viewarticle/964853

Dec 15th, 2021 - National Football League players are nearly four times more likely to develop amyotrophic lateral sclerosis (ALS) than men in the general population, with long-term players at greatest risk, a new study shows. The findings are the latest to show i...

HCQ and MS; Guillain-Barre and COVID Vax; Neural Fingerprints Can Tell Who You Are
https://www.medpagetoday.com/neurology/generalneurology/95120

Oct 19th, 2021 - The antimalarial drug hydroxychloroquine (HCQ) was associated with reduced disability worsening in people with primary progressive multiple sclerosis (MS), a phase II trial showed. (Annals of Neurology) The FDA approved injectable high-dose naloxo...

ALS-Lipids Link, Eye Disease and Heightened Dementia Risk; Parkinson's and NSAIDs
https://www.medpagetoday.com/neurology/generalneurology/94613

Sep 21st, 2021 - Elevated levels of HDL and apolipoprotein A1 were linked to a lower risk of amyotrophic lateral sclerosis (ALS), U.K. Biobank data showed. (Journal of Neurology, Neurosurgery, & Psychiatry) Also from the U.K. Biobank cohort: age-related macular de...

Lipid Levels Tied to ALS Risk
https://www.medscape.com/viewarticle/958730

Sep 14th, 2021 - Elevated levels of high-density lipoprotein (HDL) and apolipoprotein A1 (apoA1) are associated with a reduced risk for amyotrophic lateral sclerosis (ALS), new research shows. The study also linked a higher ratio of total cholesterol to HDL with a...

AstraZeneca's Antibody Therapy Prevents COVID-19, Study Shows
https://www.medscape.com/viewarticle/956953

Aug 23rd, 2021 - (Reuters) - AstraZeneca's new antibody therapy reduced the risk of people developing COVID-19 symptoms by 77% in a late-stage trial, putting the drugmaker on track to offer protection to those who respond poorly to vaccines. The company said on Fr...

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Patient Education  11 results see all →