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About 20,583 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  7,165 results

The role of spirituality in people with amyotrophic lateral sclerosis and their caregiv...
https://doi.org/10.1017/S1478951522001511
Palliative & Supportive Care; Gonçalves F, Teixeira MI et. al.

Dec 6th, 2022 - There are few studies evaluating the role of spirituality and the role of spiritually integrated interventions in people with amyotrophic lateral sclerosis (PALS) and their caregivers. A scoping review was conducted to examine the nature and bread...

Safety and Efficacy of Edaravone in Patients with Amyotrophic Lateral Sclerosis: A Syst...
https://doi.org/10.1007/s40261-022-01229-4
Clinical Drug Investigation; Gao M, Zhu L et. al.

Dec 4th, 2022 - The efficacy and safety of edaravone for the treatment of amyotrophic lateral sclerosis (ALS) remain unclear. The aim of this meta-analysis was to provide evidence-based medical guidance and advice for the clinical application of edaravone in the ...

Small-fibre neuropathy in patients with familial Amyotrophic Lateral Sclerosis type 8.
https://doi.org/10.1017/cjn.2022.331
The Canadian Journal of Neurological Sciences. Le Journal... Machado-Costa MC, Mitne-Neto M et. al.

Dec 3rd, 2022 - Small-fibre neuropathy in patients with familial Amyotrophic Lateral Sclerosis type 8.|2022|Machado-Costa MC,Mitne-Neto M,Costa LHD,Alves LM,Oliveira ASB,|

Association Between Serum Lipids and Survival in Patients With Amyotrophic Lateral Scle...
https://doi.org/10.1212/WNL.0000000000201657
Neurology Janse van Mantgem MR, van Rheenen W et. al.

Dec 3rd, 2022 - To explore the association between lipids, polygenic profile scores (PPS) for biomarkers of lipid metabolism, markers of disease severity, and survival in patients with Amyotrophic Lateral Sclerosis (ALS). We meta-analyzed the current literature o...

A survey of current practice in genetic testing in amyotrophic lateral sclerosis in the...
https://doi.org/10.1080/21678421.2022.2150556
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; De Oliveira HM, Soma A et. al.

Dec 3rd, 2022 - Objective: To determine the current practice in genetic testing for patients with apparently sporadic motor neurone disease/amyotrophic lateral sclerosis (MND/ALS) and asymptomatic at-risk relatives of familial MND/ALS patients seen in specialized...

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Guidelines  3 results

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 9th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

ESPEN guideline clinical nutrition in neurology.
https://doi.org/10.1016/j.clnu.2017.09.003
Clinical Nutrition (Edinburgh, Scotland); Burgos R, Bretón I et. al.

Dec 25th, 2017 - Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 14th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  18 results see all →

Clinicaltrials.gov  539 results

Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial
https://clinicaltrials.gov/ct2/show/NCT05189106

Oct 14th, 2022 - Overview of Clinical Trial: Many age-associated neurodegenerative diseases, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), are associated with increased inflammatory signaling in the central nervous system. While there...

TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps
https://clinicaltrials.gov/ct2/show/NCT04998305

Oct 13th, 2022 - In Japan, TJ-68 is a common Kampo medicine prescribed by Japanese physicians to manage muscle cramps or pain of diverse origins. In the USA, there are no effective medications to control muscle cramps and no approved medications to specifically tr...

A Study of BIIB067 When Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation
https://clinicaltrials.gov/ct2/show/NCT04856982

Oct 13th, 2022 - The primary objective of this study is to evaluate the efficacy of BIIB067 when initiated in presymptomatic adult carriers of a superoxide dismutase 1 (SOD1) mutation with elevated neurofilament (NF). The secondary objectives of this study are to ...

Study to Investigate the Efficacy and Safety of FAB122 (Daily Oral Edaravone) in Patients With Amyotrophic Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT05178810

Oct 13th, 2022 - Multicenter, multinational, double-blind, randomized (2:1), placebo-controlled Phase III study to investigate the efficacy and safety of 100 mg FAB122 once daily as oral formulation in ALS patients.

A Study of Monepantel in Individuals With Motor Neurone Disease
https://clinicaltrials.gov/ct2/show/NCT04894240

Oct 12th, 2022 - Amyotrophic lateral sclerosis/ Motor Neurone Disease (ALS/MND) is a rare and invariably fatal neurological disease. ALS/MND has a terribly high burden on patients, family and carers, and carries great socioeconomic burden. Current best treatment o...

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News  480 results

High Drug Costs Exclude Most Neurology Patients From Cutting-Edge Treatment
https://www.medscape.com/viewarticle/984953

Dec 2nd, 2022 - Because of high out-of-pocket costs of new-to-market neurologic drugs that are of similar benefit as older agents, only a small percentage of patients with neurologic disorders have access to these cutting-edge medications, new research shows. "Ou...

Trending Clinical Topic: Vitamin B12
https://www.medscape.com/viewarticle/983670

Nov 11th, 2022 - Each week, we identify one top search term, speculate about what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, share them with us on Twitter or Facebook.  The potentia...

Amyotrophic Lateral Sclerosis (ALS)
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/336726

Learn about this progressive disease attacks the nerve cells that control voluntary movement.

Dementia Prediction and Blood Tests; Paraquat and Parkinson's; NIH Issues CTE Stance
https://www.medpagetoday.com/neurology/generalneurology/101415

Oct 25th, 2022 - Alzheimer's blood biomarkers indicated underlying pathology but added little to current 5-year dementia risk prediction models in people with subjective cognitive complaint or mild cognitive impairment. (Neurology) About one-third of patients spon...

Novel gene-based therapies for neuromuscular diseases
https://www.mdedge.com/neurology/article/258357/rare-diseases/novel-gene-based-therapies-neuromuscular-diseases
Nahomi Yewhalashet, Larry J. Davis, PharmD

Oct 15th, 2022 - Neuromuscular diseases (NMDs) are a broad classification of heterogeneous groups of disorders characterized by progressive muscle weakness resulting from muscle or nerve dysfunction. 1 Diagnosis is based on symptoms and a full medical history, as w.

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Patient Education  28 results see all →