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About 355 results

ALLMedicine™ Primary Lateral Sclerosis Center

Research & Reviews  132 results

Cerebellar degeneration in primary lateral sclerosis: an under-recognized facet of PLS.
https://doi.org/10.1080/21678421.2021.2023188
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; Finegan E, Siah WF et. al.

Jan 8th, 2022 - While primary lateral sclerosis (PLS) has traditionally been regarded as a pure upper motor neuron disorder, recent clinical, neuroimaging and postmortem studies have confirmed significant extra-motor involvement. Sporadic reports have indicated t...

AI-based protein structure databases have the potential to accelerate rare diseases res...
https://doi.org/10.1016/j.drudis.2021.12.018
Drug Discovery Today; Rossi Sebastiano M, Ermondi G et. al.

Dec 28th, 2021 - Artificial intelligence (AI)-based protein structure databases are expected to have an impact on drug discovery. Here, we show how AlphaFold could support rare diseases research programs. We focus on Alsin, a protein responsible for rare motor neu...

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient...
https://doi.org/10.1038/s41434-021-00303-4
Gene Therapy; Genç B, Jara JH et. al.

Dec 3rd, 2021 - There are no effective cures for upper motor neuron (UMN) diseases, such as amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, and hereditary spastic paraplegia. Here, we show UMN loss occurs independent of spinal motor neuron degener...

The expanding clinical and genetic spectrum of alsin-related disorders: the first cohor...
https://doi.org/10.1080/21678421.2021.1910306
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; Alves De Siqueira Carvalho A, Antônio Troccoli Chieia M et. al.

Nov 6th, 2021 - There are three types of autosomal recessive disorders involving pathogenic variants in the ALS2 gene (OMIM*606352), infantile ascending hereditary spastic paraplegia (IAHSP), juvenile primary lateral sclerosis (JPLS) and juvenile amyotrophic late...

Electromyographic findings in primary lateral sclerosis during disease progression.
https://doi.org/10.1016/j.clinph.2021.08.022
Clinical Neurophysiology : Official Journal of the Intern... Silva CS, Santos MO et. al.

Oct 30th, 2021 - To characterize electromyographic (EMG) findings in patients with primary lateral sclerosis (PLS) during the disease course. In PLS patients we scored spontaneous activity and motor unit action potential (MUP) pattern on EMG. We compared patients ...

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Clinicaltrials.gov  5 results

Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT03929068

Jun 7th, 2021 - Motivated by the success of dopaminergic drugs in treating rigidity associated with Parkinson's disease, some neurologists have used carbidopa-levodopa (Sinemet) to attempt to improve spasticity in ALS and PLS patients. However, data on the effica...

Imaging Biomarkers in ALS
https://clinicaltrials.gov/ct2/show/NCT02567136

Mar 12th, 2021 - The purpose of the study is to determine if we are able to find one or more biomarkers of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS) using magnetic resonance imaging (MRI) scans at different levels, 3 tesla (3T) and 7 ...

Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT00334516

May 31st, 2019 - Objective: The goal of this study is to see whether patterns of cerebral cortex dysfunction differ in Primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS). The function of several regions of the cerebral cortex will be assessed ...

Brain Activity During Production of Movement
https://clinicaltrials.gov/ct2/show/NCT00029939

Jul 2nd, 2017 - Human voluntary movement is associated with at least two distinct types of scalp electroencephalographic (EEG) changes. Event-related potentials are slow, with DC signals developing in the bifrontal region as early as 1.5 seconds prior to movement...

Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease
https://clinicaltrials.gov/ct2/show/NCT01776970

Mar 9th, 2017 - CANALS project has as a main objective to analyse the safety profile, tolerability and efficacy of a Cannabis Sativa (Sativex) derivative on patients affected by spasticity due to motor neuron disease. Muscular rigidity (or spasticity) is a sympto...

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News  4 results

New Compound Promising for ALS, Other Upper Motor Neuron Diseases
https://www.medscape.com/viewarticle/947056

Mar 11th, 2021 - NEW YORK (Reuters Health) - A new compound, NU-9, improved diseased upper motor neurons (UMN) in mice and shows promise for treating amyotrophic lateral sclerosis (ALS) in humans, though more work is needed before a clinical trial can be started, ...

Spasticity in MND Improved With Cannabinoid Oral Spray
https://www.medscape.com/viewarticle/906954

Dec 24th, 2018 - Nabiximols, a cannabinoid-based oral spray (Sativex, GW Pharmaceuticals) approved outside the United States for various multiple sclerosis (MS) symptoms, shows benefit in improving spasticity and pain in motor neuron disease when administered as a...

Cannabis Extract Spray Reduces Spasticity in Patients With MND
https://www.staging.medscape.com/viewarticle/864049

May 31st, 2016 - COPENHAGEN — A cannabis extract reduces spasticity and is safe in patients with motor neuron diseases (MND), including amyotrophic lateral sclerosis (ALS), results of the phase 2 randomized multicenter CANALS trial suggest. A major symptom for pat...

Cannabis Extract Spray Reduces Spasticity in Patients With MND
https://www.medscape.com/viewarticle/864049

May 31st, 2016 - COPENHAGEN — A cannabis extract reduces spasticity and is safe in patients with motor neuron diseases (MND), including amyotrophic lateral sclerosis (ALS), results of the phase 2 randomized multicenter CANALS trial suggest. A major symptom for pat...

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Patient Education  1 results see all →