ALLMedicine™ Anticholinergic Toxicity Center

Sep 4th, 2021 - The incidence of anticholinergic syndrome due to second generation antihistamines is infrequently reported. Largely due to their decreased affinity for central nervous system (CNS) receptors, second generation antihistamines are rarely associated ...

May 25th, 2021 - While antipsychotic medications have long been associated with anticholinergic effects, asenapine has been purported to have no capacity for muscarinic cholinergic antagonism based on in vitro studies. Research in rat brain tissue has yielded diff...

Jun 6th, 2020 - History For all patients with suspected poisoning, determine the precise substance(s) ingested, time of ingestion, quantity ingested, rationale for ingestion, and co-ingestants. Ascertain patient compliance, medical history, prescription medicatio...

Jun 6th, 2020 - Medication Summary Medical therapy consists of anticonvulsants, antitachydysrhythmics, sodium bicarbonate, physostigmine, and sedatives. The standard dose of physostigmine is 0.5-2 mg, given by slow iintravenous push (not to exceed 1 mg/min). Howe...

Oct 31st, 2019 - Brugmansia suaveolens is the commonest species under the Solanacea ("Angels Trumpet" in English; "Attana" in Sinhalese) plant family in Sri Lanka. It contains alkaloids like scopolamine, atropine and hyoscyamine which can cause an anticholinergic ...

Nov 9th, 2021 - Emergency physicians need to be able to detect and manage antidepressant and benzodiazepine overdoses, Craig Smollin, MD, professor of clinical emergency medicine, University of California San Francisco (UCSF), said in a presentation at the Americ...

Dec. 18, 2017: The FDA proposed a new, risk-based enforcement approach to drug products labeled as homeopathic. More here. Español What action did the FDA take? On October 23, 2010, the U.S. Food and Drug Administration (FDA) warned consumers to s...

Feb 24th, 2017 - Besides serotonin syndrome, other differential diagnoses were considered but excluded in this case. Neuroleptic malignant syndrome (NMS) is an idiopathic drug reaction to antipsychotics that has a presentation similar to that of serotonin syndrome...

It is not clear whether a single 25-mg dose of meclizine—an H1-receptor antagonist—played a role in Mr. A’s psychotic symptoms.

Neuroleptic malignant syndrome (NMS) is an uncommon but by no means rare side effect of antipsychotics and other dopamine-blocking agents. This life-threatening form of drug-induced hyperthermia can be disastrous if missed, as initial treatment is.