About 1,450 results

ALLMedicine™ Hyperammonemia Center

Research & Reviews  530 results

Survival benefit of L-carnitine supplementation in patients with cirrhosis.
JPEN. Journal of ParEnteral and Enteral Nutrition; Miwa T, Hanai T et. al.

May 6th, 2022 - L-carnitine supplementation is effective in improving muscle cramps, hyperammonemia, and hepatic encephalopathy in patients with cirrhosis. However, limited evidence is available on the effect of L-carnitine supplementation on the survival of pati...

Toxic benzyl alcohol inhalation: Altered mental status with metabolic acidosis and hype...
The American Journal of Emergency Medicine; Inada M, Kato H et. al.

Apr 26th, 2022 - This report presents the case of a patient whose inhalation exposure to benzyl alcohol led to clinical manifestations similar to toluene intoxication, including sudden altered mental status, metabolic acidosis, hypokalemia, hypophosphatemia, and h...

Undifferentiated non-hepatic hyperammonemia in the ICU: Diagnosis and management.
Journal of Critical Care; Long MT, Coursin DB

Apr 22nd, 2022 - Hyperammonemia occurs frequently in the critically ill but is largely confined to patients with hepatic dysfunction or failure. Non-hepatic hyperammonemia (NHHA) is far less common but can be a harbinger of life-threatening diagnoses that warrant ...

Presentation, Management and Outcome of Congenital Portosystemic Shunts in Children: Th...
Journal of Pediatric Gastroenterology and Nutrition; Fahmy DM, Mitchell PD et. al.

Apr 21st, 2022 - Congenital portosystemic shunts (CPSS) are rare vascular malformations. We describe presentations, complications, associations, and outcomes of CPSS at Boston Children's Hospital (BCH). This was a retrospective review of children with CPSS at BCH ...

Inherited metabolic diseases mimicking hereditary spastic paraplegia (HSP): a chance fo...
https://doi.org/10.1007/s10048-022-00688-3 10.1016/j.jns.2017.10.010 10.1007/s12311-016-0803-z 10.1016/j.expneurol.2014.06.011 10.1002/mds.26944 10.1016/B978-0-444-53486-6.00038-7 10.1007/s00401-013-1115-8 10.1097/WCO.0b013e3282f190ba 10.1002/mds.27568 10.3389/fneu.2020.582160 10.1212/WNL.0b013e31826d5fb0 10.1002/mds.27655 10.1136/jnnp-2018-318666 10.1136/practneurol-2016-001485 10.1136/practneurol-2011-000069 10.1136/jnnp.2008.144121 10.1007/s00415-019-09432-8 10.2174/0929867325666180313105949 10.2174/1381612811319140008 10.1186/s13023-018-0767-9 10.1007/s10897-016-9956-7 10.1111/ene.13557 10.1001/jamaneurol.2014.116 10.1001/jamaneurol.2013.4915 10.1007/s10545-016-9991-4 10.1002/humu.22970 10.1212/WNL.56.8.1113 10.1016/j.ymgme.2013.07.018 10.1097/MD.0000000000017334 10.1007/s007020200026 10.1002/mdc3.12211 10.1038/nrneurol.2015.86 10.1002/brb3.906 10.1007/s00415-014-7265-3 10.1016/j.parkreldis.2020.03.019 10.1007/s10072-006-0618-7 10.1007/s10545-017-0093-8 10.1186/s13023-014-0179-4 10.1016/j.parkreldis.2018.07.006 10.1111/j.1468-1331.2011.03439.x 10.1007/s10545-014-9745-0 10.1136/practneurol-2015-001117 10.1007/s10072-019-04169-8 10.3389/fneur.2019.00131 10.1093/brain/awv247 10.1007/s10545-011-9411-8 10.1002/jimd.12100 10.1016/j.ymgmr.2020.100689 10.1016/j.ymgme.2011.06.001 10.1016/S0887-8994(03)00042-0 10.1038/gim.2011.6 10.1007/s11011-017-9984-5 10.1177/088307389400900213 10.1016/j.ejpn.2011.04.012 10.1016/j.ymgme.2010.01.003 10.1177/1352458515596457 10.1002/epi4.12414 10.1016/j.neurol.2013.09.005 10.1007/s11910-013-0342-7 10.1530/eje.0.1500627 10.1016/j.ejmg.2016.10.003 10.1016/j.ejpn.2019.02.010 10.1016/j.ejpn.2018.12.004 10.1002/mdc3.12858 10.1002/jdn.10003 10.1007/s00415-009-5358-1
Neurogenetics Teive HAG, Camargo CHF et. al.

Apr 10th, 2022 - The syndromic group of hereditary spastic paraplegias has a heterogeneous clinical profile and a broad differential diagnosis, including neurometabolic disorders that are potentially treatable. This group includes 5,10-methylenetetrahydrofolate re...

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Guidelines  1 results

Extracorporeal treatment for valproic acid poisoning: systematic review and recommendat...
Clinical Toxicology (Philadelphia, Pa.); Ghannoum M, Laliberté M et. al.

May 8th, 2015 - The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup presents its systematic review and clinical recommendations on the use of extracorporeal treatment (ECTR) in valproic acid (VPA) poisoning. The lead authors reviewed all of the articles...

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Drugs  25 results see all →

Clinicaltrials.gov  13 results

s100β, NSE n GFAP in Living Donor Hepatectomy and Delirium

Jan 11th, 2022 - The postoperative delirium picture is a serious and common complication seen after any major surgery, including hepatic resection. Delirium is an acute state of confusion characterized by impaired consciousness, reduced ability to focus on attenti...

Manipulating the Gut Microbiome Study

Dec 15th, 2021 - This project will study the efficacy and safety of the pharmacologic blockade of urease in the nitrogen salvage pathway of intestinal microbes in subjects with partial urea cycle disorders. Additional trapping of ammonia as excretable urea may res...

Systemic Biomarkers of Brain Injury From Hyperammonemia

Nov 1st, 2021 - Ammonia is a waste product of protein and amino acid catabolism and is also a potent neurotoxin. The onslaught of high blood ammonia levels on the brain can manifest as cytotoxic brain edema and vascular compromise leading to intellectual and deve...

Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy

Aug 20th, 2021 - Readmission rates for patients with hepatic encephalopathy due to end stage liver disease are high. Hyperammonemia contributes significantly to encephalopathy and occurs because of impaired hepatic ureagenesis and increased skeletal muscle proteol...

HMB for Denutrition in Patients With Cirrhosis (HEPATIC)

May 4th, 2021 - 1. Scientific & technical aspects State of the art: Patients with cirrhosis present a chronic inflammatory state and alterations in protein metabolism. These alterations lead to elevated levels of insulin and catecholamines along with the developm...

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News  11 results

Hyperammonemia in Children With Kidney Replacement Therapy Clinical Practice Guidelines (2020)

May 29th, 2020 - In April 2020, the Pediatric Continuous Renal Replacement Therapy Workgroup published their recommendations for the management of hyperammonemia in pediatric patients receiving continuous kidney replacement therapy.[1] Medical Therapy for Hyperamm...

Microbiome – Impact on health and disease
Gary D. Wu, MD

Jul 15th, 2019 - The gut microbiota influences our biology through our mucosal immune system as well as by leading to the production of bioactive small molecules. I’ll describe how gut microbiota influences colon cancer, liver disease, the production of bioactive.

Winners all

Dec 3rd, 2018 - Case Report Slide Winners Ze Ying Tan: All that wheezes is not asthma Jason Lam: Pulmonary mucor mycetoma Adam Young: Nonresolving pneumonia and cyclic fevers in an immunocompetent patient Ritu Modi: Histopathological misdiagnosis of pulmonary coc.

Advice for Combating Frailty's Fatal Impact in Liver Disease

Jan 22nd, 2018 - Role of Sarcopenia Frailty in patients with cirrhosis appears to be in part a consequence of sarcopenia.[16] In those with cirrhosis, sarcopenia is associated with decreased survival, increased risk for complications (eg, infection), and a poorer ...

Rare Disease Treatments Make Up Top 10 Most Costly Drugs

May 2nd, 2017 - UPDATED May 4, 2017 // The world's top 10 most expensive drugs are all orphan drugs for rare and ultrarare diseases, according to a new analysis. Leading that pack at number 1 is glycerol phenylbutyrate (Ravicti, Horizon Pharma), an orphan drug ap...

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