ALLMedicine™ Cerebral Amyloid Angiopathy Center

Jun 28th, 2022 - Accumulating data suggest that cerebrovascular disease contributes to Alzheimer's disease pathophysiology and progression toward dementia. Cerebral amyloid angiopathy is a form of cerebrovascular pathology that results from the build-up of β-amylo...

Jun 28th, 2022 - Neurodegenerative diseases are widespread yet challenging to diagnose and stage antemortem. As an extension of the central nervous system, the eye harbors retina ganglion cells vulnerable to degeneration, and visual symptoms are often an early man...

Jun 22nd, 2022 - Vascular lesions may be a common finding also in Alzheimer's dementia, but their role on cognitive status is uncertain. to investigate their distribution in patients with Alzheimer's, vascular or mixed dementia and detect any distinctive neuroradi...

Jun 21st, 2022 - Early onset Alzheimer's disease (EOAD) represents a diagnostic challenge and is associated with a high diagnostic delay and misdiagnosis. To describe clinical and pathological data from a pathologically confirmed EOAD cohort and evaluate evolving ...

Jun 18th, 2022 - Cerebral amyloid angiopathy (CAA) is characterized by β-amyloid deposition in cortical and leptomeningeal arterioles, which might result from glymphatic dysfunction. We aimed to explore glymphatic function in CAA using the non-invasive diffusion t...

Jun 6th, 2022 - Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging (SWI) in the major...

Mar 16th, 2022 - Patients with acute lobar ICH fulfilling the Boston criteria for probable or possible CAA will be enrolled within 30 days after ICH onset. Brain MRI performed at baseline will be analyzed blinded to clinical data. Patients with presence of cSS wil...

Mar 8th, 2022 - The investigators propose to leverage the recruitment, DNA, RNA-seq and baseline advanced neuroimaging cohort of ROSE to obtain long-term neuroimaging and identical assessments longitudinally to address critical questions regarding the progressive...

Feb 11th, 2022 - Transthyretin amyloidosis (aTTR) initially described as a rare disease, became the most serious hereditary polyneuropathy of adult onset and family screening has made it possible to identify and follow up many asymptomatic patients and carriers of...

Jan 26th, 2022 - CAA is a cerebrovascular disease caused by the deposition of β-amyloid in the walls of arteries, arterioles, and capillaries in the cerebral cortex and overlying leptomeninges. It is often associated with repeated lobar intracerebral hemorrhages, ...

May 3rd, 2021 - Survivors of intracerebral hemorrhage had three times the risk of ischemic stroke compared with the general population, and twice the risk of myocardial infarction (MI), an analysis of U.S. population-based cohort studies found. In a study of near...

Jul 14th, 2020 - Apathy, but not depression, predicted dementia in cerebral small vessel disease. (Journal of Neurology, Neurosurgery & Psychiatry) Cerebral organoids grown from strands of hair from Down syndrome donors showed potential as an early drug testing pl...

May 22nd, 2020 - Excessive sleep disturbances are linked to increased cognitive decline in patients with Alzheimer's disease (AD), new research suggests. Records from the National AD Coordinating Center (NACC) datasets for more than 400 patients with autopsy-confi...

Jun 4th, 2019 - MILAN — Patients presenting with mixed intracranial hemorrhage (ICH) features on MRI — that is, ICH or microbleeds in both lobar and deep areas of the brain — are at higher risk for worse outcomes vs those with strictly lobar or deep ICH presentat...

May 1st, 2019 - Although trauma is the most common cause of ICH, ICH can develop from nontraumatic etiologies. Hypertensive damage to blood vessel walls (eg, hypertension, eclampsia, drug abuse) is the most common cause of nontraumatic ICH. Other, less common non...