About 8,993 results

ALLMedicine™ Parkinson Disease Center

Research & Reviews  3,340 results

Cancer in Parkinson Disease: an approximation to the main risk factors.
Neuro-degenerative Diseases; Rosas I, Morís G et. al.

Oct 22nd, 2021 - Many evidences suggest a pathological link between neurodegenerative diseases and cancer. In fact, several epidemiologic studies indicate a a decreased incidence of most cancer types in Parkinson's disease (PD) patients and some PD genes are invol...

General Anesthesia and Progression of Parkinson Disease: A Shaky Association.
Anesthesia and Analgesia; Crosby G, Vutskits L

Oct 22nd, 2021 - General Anesthesia and Progression of Parkinson Disease: A Shaky Association.|2021|Crosby G,Vutskits L,|

Anesthetic Effects on the Progression of Parkinson Disease in the Rat DJ-1 Model.
Anesthesia and Analgesia; Xu DA, DeYoung TP et. al.

Oct 22nd, 2021 - Parkinson disease is a chronic and progressive movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The causes of Parkinson disease are not clear but may involve genetic susceptibilities...

Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting...
Clinical Pharmacology in Drug Development; Wilbraham D, Biglan KM et. al.

Oct 20th, 2021 - Mevidalen (LY3154207) is a positive allosteric modulator of the dopamine D1 receptor that enhances the affinity of dopamine for the D1 receptor. The safety, tolerability, motor effects, and pharmacokinetics of mevidalen were studied in patients wi...

Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection.
Pharmacological Reviews; Pirooznia SK, Rosenthal LS et. al.

Oct 20th, 2021 - Parkinson disease (PD) used to be considered a nongenetic condition. However, the identification of several autosomal dominant and recessive mutations linked to monogenic PD has changed this view. Clinically manifest PD is then thought to occur th...

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Drugs  7 results see all →

Clinicaltrials.gov  65 results

Improvisational Movement for People With Memory Loss and Their Caregivers

Sep 30th, 2021 - Dementia is a progressive decline in cognition that impairs a person's ability to perform activities of daily living. Alzheimer's disease is the most common form of dementia, the most common neurodegenerative disease in older adults, and the 6th l...

Real-Time Levodopa Level Monitoring in Parkinson Disease

Sep 29th, 2021 - People with Parkinson disease (PD) lack the chemical dopamine, which is important for movement. Levodopa replaces dopamine and restores normal motor function in PD. Early in the disease stages, people with PD benefit significantly from levodopa. H...

Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease

Sep 16th, 2021 - Postural instability, gait impairment, and falls are among the greatest unmet needs in Parkinson disease (PD). A single fall can be catastrophic, and impairments that limit mobility lead to social isolation or depression, and adversely affect bone...

Behavioral or Solifenacin Therapy for Urinary Symptoms in Parkinson Disease

Sep 2nd, 2021 - The number of persons with Parkinson Disease (PD) in the United States is expected to double by 2030 as the population ages. Importantly, this increase in the prevalence of PD will have greater impact within the Department of Veterans Affairs (VA)...

Everyday Memory Impairment in PD-related Cognitive Decline

Jul 22nd, 2021 - Parkinson disease (PD) causes cognitive deficits that can impair instrumental activities of daily living function and quality of life (QOL) even in the absence of dementia. Currently, there are no treatments to address this pressing burden and, ev...

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News  183 results

Sublingual Film Well-Tolerated for Parkinson 'Off' Episodes

Sep 19th, 2021 - A majority of patients with Parkinson disease (PD) experiencing "off" episodes  successfully tolerated titration to an effective and tolerable dose of sublingual apomorphine film (SL-apo; Kynmobi, Sunovion Pharmaceuticals) without the use of antie...

General or Local Anesthesia for Deep Brain Stimulation Surgery: Which Is Best?

Sep 14th, 2021 - The outcome of deep brain stimulation (DBS) surgery for Parkinson disease (PD) is comparable when performed under general or local anesthesia, results of a new randomized trial show. Investigators note that postoperative confusion frequently occur...

Agent Orange Tied to Increased Dementia Risk in Vietnam Vets

Jan 26th, 2021 - Exposure to the herbicide Agent Orange has been tied to a significantly increased risk for dementia in Vietnam War veterans, new research shows. Investigators at the University of California, San Francisco, found that veterans who had been exposed...

Noted Researcher Sees ERT as Remarkable Beginning

Dec 20th, 2020 - Pramod Kumar Mistry, MBBS, PhD The treatment of Gaucher disease is poised to enter a new era as a result of advances in the understanding of the cellular pathways at work in the disorder, according to Pramod Kumar Mistry, MBBS, PhD, whose resear...

Stem Cells Create a Therapeutic Niche

Dec 5th, 2020 - Stem cell therapy has gained increasing traction in various therapeutic areas, from cancer to diabetes to ocular regeneration. Although the use of embryonic stem cells is controversial, remarkable research in the field of adult induced pluripotent...

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Patient Education  2 results see all →