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About 8,323 results

ALLMedicine™ Down Syndrome Center

Research & Reviews  3,034 results

Co-infection of intestinal tuberculosis and mucormycosis in a patient with Down syndrom...
https://doi.org/10.1136/bcr-2021-244903
BMJ Case Reports; Pal B, Thirupathaiah K et. al.

Dec 2nd, 2021 - Mucormycosis represents several unusual opportunistic infection caused by saprophytic aseptate fungi. There is a recent rise in cases of mucormycosis due to an increase in diabetic and immunodeficient patients like patients on long-term steroids, ...

DSCAM deficiency leads to premature spine maturation and autism-like behaviors.
https://doi.org/10.1523/JNEUROSCI.1003-21.2021
The Journal of Neuroscience : the Official Journal of The... Chen P, Liu Z et. al.

Dec 2nd, 2021 - Mutations in some cell adhesion molecules (CAMs) cause abnormal synapse formation and maturation, and serve as one of the potential mechanisms of autism spectrum disorders (ASDs). Recently, DSCAM (Down syndrome cell adhesion molecule) was found to...

Risks of late mortality and morbidity among survivors of childhood acute leukemia with ...
https://doi.org/10.1002/cncr.34042
Cancer Gupta S, Sutradhar R et. al.

Dec 1st, 2021 - Children with leukemia and Down syndrome (DS) are at higher risk of acute treatment toxicities than those without DS. Whether late toxicity risks are also elevated is unknown. The authors identified all patients diagnosed with leukemia before the ...

Extracapsular versus intracapsular tonsillectomy: Outcomes in children with a focus on ...
https://doi.org/10.1016/j.ijporl.2021.110978
International Journal of Pediatric Otorhinolaryngology; Mukerji SS, Rath S et. al.

Nov 29th, 2021 - Outcomes following intracapsular tonsillectomy (IT) have not been well established in children with developmental delays. The objective of this study was to compare outcomes and complications between intracapsular and extracapsular tonsillectomy (...

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Guidelines  11 results

Medical Care of Adults With Down Syndrome: A Clinical Guideline.
https://doi.org/10.1001/jama.2020.17024
JAMA Tsou AY, Bulova P et. al.

Oct 21st, 2020 - Down syndrome is the most common chromosomal condition, and average life expectancy has increased substantially, from 25 years in 1983 to 60 years in 2020. Despite the unique clinical comorbidities among adults with Down syndrome, there are no cli...

No. 261-Prenatal Screening for Fetal Aneuploidy in Singleton Pregnancies.
https://doi.org/10.1016/j.jogc.2017.06.013
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Chitayat D, Langlois S et. al.

Sep 2nd, 2017 - To develop a Canadian consensus document on maternal screening for fetal aneuploidy (e.g., Down syndrome and trisomy 18) in singleton pregnancies. Pregnancy screening for fetal aneuploidy started in the mid 1960s, using maternal age as the screeni...

No. 262-Prenatal Screening for and Diagnosis of Aneuploidy in Twin Pregnancies.
https://doi.org/10.1016/j.jogc.2017.06.015
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Audibert F, Gagnon A

Sep 2nd, 2017 - To provide a Canadian consensus document with recommendations on prenatal screening for and diagnosis of fetal aneuploidy (e.g., Down syndrome and trisomy 18) in twin pregnancies. The process of prenatal screening and diagnosis in twin pregnancies...

Practice Bulletin No. 162 Summary: Prenatal Diagnostic Testing for Genetic Disorders.
https://doi.org/10.1097/AOG.0000000000001438
Obstetrics and Gynecology;

Apr 23rd, 2016 - Prenatal genetic diagnostic testing is intended to determine, with as much certainty as possible, whether a specific genetic disorder or condition is present in the fetus. In contrast, prenatal genetic screening is designed to assess whether a pat...

Practice Bulletin No. 162: Prenatal Diagnostic Testing for Genetic Disorders.
https://doi.org/10.1097/AOG.0000000000001405
Obstetrics and Gynecology;

Mar 5th, 2016 - Prenatal genetic diagnostic testing is intended to determine, with as much certainty as possible, whether a specific genetic disorder or condition is present in the fetus. In contrast, prenatal genetic screening is designed to assess whether a pat...

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Clinicaltrials.gov  84 results

A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia
https://clinicaltrials.gov/ct2/show/NCT03914625

Nov 4th, 2021 - PRIMARY OBJECTIVES: I. To determine in a randomized manner if the addition of 2 cycles of blinatumomab to standard therapy improves disease-free survival (DFS) in patients with standard risk (SR) B-ALL and higher risk features (SR-High), and patie...

Diagnosis Accuracy of Noninvasive Screening by PCR Digital for Down Syndrom
https://clinicaltrials.gov/ct2/show/NCT02872948

Nov 1st, 2021 - Context Currently, non-invasive screening test for trisomy 21 (Down syndrome) is proposed to every pregnant woman. This first trimester combined test consists of ultrasound nuchal translucency measurement, associated with different maternal serum ...

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome
https://clinicaltrials.gov/ct2/show/NCT02521493

Oct 19th, 2021 - PRIMARY OBJECTIVES: I. To determine the 2-year event-free-survival (EFS) for children with standard risk Down syndrome (DS) acute myeloid leukemia (AML) (minimal residual disease [MRD]-negative after one cycle of induction therapy) after eliminati...

Dilated Versus Non-Dilated Wavefront Corrections for Patients With Down Syndrome
https://clinicaltrials.gov/ct2/show/NCT05059041

Oct 12th, 2021 - Individuals with Down syndrome (DS) live with visual deficits due, in part, to elevated levels of higher-order optical aberrations (HOA). HOAs are distortions/abnormalities in the structure of the refractive components of the eye (i.e. the cornea ...

Hypotension in Children With Down Syndrome With Anesthesia Induction
https://clinicaltrials.gov/ct2/show/NCT04603469

Sep 30th, 2021 - Children generally undergo induction of anesthesia by inhalation of sevoflurane. This is particularly relevant for children with developmental delays as to avoid placement of an IV while awake. However, children with Down Syndrome experience brady...

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News  186 results

Key Part of Arizona Genetic-Abnormality Abortion Law Blocked
https://www.medscape.com/viewarticle/959941

Sep 29th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. PHOENIX (AP) — A judge has blocked a key portion of a new Arizona law that would have let prosecutors bring felony charges against doctors who kno...

Lawsuit Seeks to Block Arizona Ban on Down Syndrome Abortion
https://www.medscape.com/viewarticle/956749

Aug 17th, 2021 - PHOENIX (AP) — Abortion-rights advocates filed a lawsuit Tuesday seeking to overturn a new Arizona law that would ban abortions because of Down syndrome or other genetic abnormalities, the latest legal fight over reproductive rights under a judici...

APOE-e4 Allele Tied to Alzheimer's Clinical and Biomarker Changes in Down Syndrome
https://www.medscape.com/viewarticle/954810

Jul 15th, 2021 - NEW YORK (Reuters Health) - In individuals with Down syndrome (DS) who developed Alzheimer's disease (AD), the APOE-e4 allele was associated with earlier clinical and biomarker changes, a cohort study shows. "Our work found that, just like in spor...

The ZUMA-3 Trial: Study Design and Patient Population
https://www.onclive.com/view/the-zuma-3-trial-study-design-and-patient-population

Jul 7th, 2021 - Eunice Wang, MD: ZUMA-3 was a phase 1 to 2 multicenter study of the safety tolerability and preliminary efficacy of KTE-X19 CAR T cells for the treatment of patients with relapsing/refractory B-ALL [B-cell acute lymphocytic leukemia] whose cells e...

Cooper Vetoes NC Bill Banning Down Syndrome Abortions
https://www.medscape.com/viewarticle/953855

Jun 28th, 2021 - RALEIGH, N.C. (AP) — North Carolina Gov. Roy Cooper on Friday vetoed a measure barring women from getting an abortion specifically because of a prenatal diagnosis of Down syndrome in a fetus. The proposal advanced by Republicans also sought to pro...

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Patient Education  14 results see all →