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About 2,488 results

ALLMedicine™ Lennox-gastaut Syndrome Center

Research & Reviews  387 results

A Study of Soticlestat as an Add-on Therapy in Children, Teenagers, and Adults With Lennox-Gastaut Syndrome
https://clinicaltrials.gov/ct2/show/NCT04938427

Jun 21st, 2022 - The drug being tested in this study is called soticlestat (TAK-935). Soticlestat will be assessed for efficacy, safety, and tolerability in pediatric and adult participants with Lennox-Gastaut syndrome (LGS). The study will enroll approximately 23...

CBD Oil for Reducing Emotional Impact of COVID-19
https://clinicaltrials.gov/ct2/show/NCT04603781

Jun 7th, 2022 - Background and Significance of the Proposed Project The COVID-19 pandemic has hit us like a ton of bricks creating unimaginable levels of unanticipated death, financial hardship, and dramatic changes in nearly every facet of our life including sch...

Different epilepsy course of a novel AHDC1 mutation in a female monozygotic twin pair.
https://doi.org/10.1016/j.seizure.2022.05.020
Seizure Salvati A, Biagioni T et. al.

Jun 1st, 2022 - De novo truncating mutations of AHDC1 gene cause Xia-Gibbs Syndrome (XGS), characterized by developmental delay, hypotonia, speech disturbances, sleep apnea. Seizures have been reported, yet no studies have depicted the epilepsy characteristics an...

Investigate the Efficacy and Safety of Carisbamate (YKP509) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults
https://clinicaltrials.gov/ct2/show/NCT05219617

May 23rd, 2022 - The secondary objectives are: To evaluate the efficacy of carisbamate (YKP509) as adjunctive treatment in reducing the total number of seizures compared with placebo in pediatric and adult subjects diagnosed with Lennox Gastaut Syndrome (LGS) Asse...

Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndrome
https://clinicaltrials.gov/ct2/show/NCT04062981

May 16th, 2022 - Subjects who successfully completed the YKP509C001 study and could benefit from continued exposure to carisbamate. This is an open-label (OL), multi-center study of carisbamate in subjects with LGS, with safety assessments from Baseline (Visit 1) ...

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Drugs  438 results see all →

Clinicaltrials.gov  43 results

A Study of Soticlestat as an Add-on Therapy in Children, Teenagers, and Adults With Lennox-Gastaut Syndrome
https://clinicaltrials.gov/ct2/show/NCT04938427

Jun 21st, 2022 - The drug being tested in this study is called soticlestat (TAK-935). Soticlestat will be assessed for efficacy, safety, and tolerability in pediatric and adult participants with Lennox-Gastaut syndrome (LGS). The study will enroll approximately 23...

CBD Oil for Reducing Emotional Impact of COVID-19
https://clinicaltrials.gov/ct2/show/NCT04603781

Jun 7th, 2022 - Background and Significance of the Proposed Project The COVID-19 pandemic has hit us like a ton of bricks creating unimaginable levels of unanticipated death, financial hardship, and dramatic changes in nearly every facet of our life including sch...

Investigate the Efficacy and Safety of Carisbamate (YKP509) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults
https://clinicaltrials.gov/ct2/show/NCT05219617

May 23rd, 2022 - The secondary objectives are: To evaluate the efficacy of carisbamate (YKP509) as adjunctive treatment in reducing the total number of seizures compared with placebo in pediatric and adult subjects diagnosed with Lennox Gastaut Syndrome (LGS) Asse...

Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndrome
https://clinicaltrials.gov/ct2/show/NCT04062981

May 16th, 2022 - Subjects who successfully completed the YKP509C001 study and could benefit from continued exposure to carisbamate. This is an open-label (OL), multi-center study of carisbamate in subjects with LGS, with safety assessments from Baseline (Visit 1) ...

Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome
https://clinicaltrials.gov/ct2/show/NCT05374824

May 16th, 2022 - Background and Significance: Lennox-Gastaut Syndrome (LGS) is a rare developmental-epileptic encephalopathy characterized by life-long refractory seizures which result in frequent utilization of emergency healthcare resources and also contribute t...

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News  127 results

Phase 3 Data on Fenfluramine for Lennox-Gastaut Published
https://www.medscape.com/viewarticle/973485

May 5th, 2022 - A daily dose of fenfluramine (Fintepla, UCB), when added to an existing anti-epileptic treatment regimen, significantly reduced the frequency of drop seizures associated with Lennox-Gastaut syndrome (LGS) in the phase 3 study that led to US approv...

Tau Moderated by Menopause; CTE Risk Underestimated; When Is a Single Study Enough?
https://www.medpagetoday.com/neurology/generalneurology/98523

May 3rd, 2022 - Menopause status moderated sex differences in tau burden, with a divergence in tauopathy between the sexes apparent 20 years earlier than previously reported. (Annals of Neurology) Plasma p-tau was a less consistent marker of brain amyloidosis in ...

Dementia-Physical Activity Link; Nausea Drugs and Stroke; Epilepsy and COVID
https://www.medpagetoday.com/neurology/generalneurology/97929

Mar 29th, 2022 - Higher levels of moderate-to-vigorous physical activity were tied to a lower risk for disabling dementia in Japanese men. (JAMA Network Open) At current expected prices, neither aducanumab (Aduhelm) nor donanemab, an investigational anti-amyloid d...

FDA Okays New Med for Lennox-Gastaut Syndrome
https://www.medscape.com/viewarticle/971158

Mar 29th, 2022 - The US Food and Drug Administration (FDA) has approved fenfluramine (Fintepla) oral solution, a Schedule IV controlled substance, for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in children aged 2 years and older, the c...

Epidiolex plus THC lowers seizures in pediatric epilepsy
https://www.mdedge.com/neurology/article/247341/epilepsy-seizures/epidiolex-plus-thc-lowers-seizures-pediatric-epilepsy
Randy Dotinga

Oct 13th, 2021 - Children and young adults with epilepsy had fewer seizures after combination treatment with the drug Epidiolex, which contains the cannabidiol (CBD), and various doses of tetrahydrocannabinol (THC), the component of cannabis that makes people high.

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