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About 2,813 results

ALLMedicine™ Neural Tube Defects Center

Research & Reviews  885 results

Vangl2-environment interaction causes severe neural tube defects, without abnormal neur...
https://doi.org/10.1242/dmm.049194
Disease Models & Mechanisms; Nychyk O, Galea GL et. al.

Nov 30th, 2021 - Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis, a severe neural tube defect (NTD). Some humans with NTDs also have PCP gene...

Disparities in Dolutegravir Uptake Affecting Females of Reproductive Age With HIV in Lo...
https://doi.org/10.7326/M21-3037
Annals of Internal Medicine; Romo ML, Patel RC et. al.

Nov 30th, 2021 - The transition to dolutegravir-containing antiretroviral therapy (ART) in low- and middle-income countries (LMICs) was complicated by an initial safety signal in May 2018 suggesting that exposure to dolutegravir at conception was possibly associat...

Assessment of embryo morphology following perinatal exposure to aspirin, ibuprofen and ...
https://doi.org/10.1080/14767058.2021.2005020
The Journal of Maternal-fetal & Neonatal Medicine : the O... Moungmaithong S, Leung BW et. al.

Nov 23rd, 2021 - Recent evidence from a meta-analysis indicates that maternal prenatal exposure, single or repeated, to non-steroidal anti-inflammatory drugs (NSAIDs) or non-opioid painkillers, is associated with increased risk of cerebral palsy and cognitive-beha...

Identifying biomarkers for prenatal diagnosis of neural tube defects based on "omics".
https://doi.org/10.1111/cge.14087
Clinical Genetics; Huang W, Gu H et. al.

Nov 12th, 2021 - Neural tube defects (NTDs) are the most severe birth defects and the main cause of newborn death; posing a great challenge to the affected children, families, and societies. Presently, the clinical diagnosis of NTDs mainly relies on ultrasound ima...

NRF2 activation inhibits valproic acid-induced neural tube defects in mice.
https://doi.org/10.1016/j.ntt.2021.107039
Neurotoxicology and Teratology; Piorczynski TB, Lapehn S et. al.

Nov 6th, 2021 - Valproic acid (VPA) is a widely prescribed medication that has traditionally been used to treat epilepsy, yet embryonic exposure to VPA increases the risk of the fetus developing neural tube defects (NTDs). While the mechanism by which VPA causes ...

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Guidelines  6 results

Guideline No. 410: Prevention, Screening, Diagnosis, and Pregnancy Management for Fetal...
https://doi.org/10.1016/j.jogc.2020.11.003
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Douglas Wilson R, Van Mieghem T et. al.

Nov 20th, 2020 - This revised guideline is intended to provide an update on the genetic aspects, prevention, screening, diagnosis, and management of fetal neural tube defects. Women who are pregnant or may become pregnant. Neural tube defect screening should be of...

ACOG Committee Opinion No. 762 Summary: Prepregnancy Counseling.
https://doi.org/10.1097/AOG.0000000000003014
Obstetrics and Gynecology;

Dec 24th, 2018 - The goal of prepregnancy care is to reduce the risk of adverse health effects for the woman, fetus, and neonate by working with the woman to optimize health, address modifiable risk factors, and provide education about healthy pregnancy. All those...

Practice Bulletin No. 187: Neural Tube Defects.
https://doi.org/10.1097/AOG.0000000000002412
Obstetrics and Gynecology;

Dec 1st, 2017 - Neural tube defects (NTDs) are congenital structural abnormalities of the central nervous system and vertebral column. Neural tube defects may occur as an isolated malformation, in combination with other malformations, as part of a genetic syndrom...

Standardized Procedural Practices of the Ontario Prenatal Screening Program for aneuplo...
https://doi.org/10.1016/j.clinbiochem.2012.06.015
Clinical Biochemistry; Lepage N, Chaudhry A et. al.

Jun 27th, 2012 - The Ontario Prenatal Screening Program (OPSP) follows internationally recognized standardized procedures for laboratories and genetics clinics. However, it has been found that some procedures are subject to interpretation, so the current procedure...

Prenatal screening for fetal aneuploidy in singleton pregnancies.
https://doi.org/10.1016/S1701-2163(16)34961-1
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Chitayat D, Langlois S et. al.

Jul 14th, 2011 - To develop a Canadian consensus document on maternal screening for fetal aneuploidy (e.g., Down syndrome and trisomy 18) in singleton pregnancies. Pregnancy screening for fetal aneuploidy started in the mid 1960s, using maternal age as the screeni...

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Drugs  68 results see all →

Clinicaltrials.gov  11 results

Formative Research Study to Address Protein Intake in Children and Analysis of Breast Milk Nutrient Content in Mothers
https://clinicaltrials.gov/ct2/show/NCT03140696

Oct 26th, 2021 - Inadequate dietary protein intake and prolonged undernourishment can lead to short term and long-term consequences, which can deplete financial, physical, and social capital, further exacerbating the cycle of undernutrition. Subsequently, undernut...

B-vitamin Levels and Adverse Pregnancy Outcomes
https://clinicaltrials.gov/ct2/show/NCT05073978

Oct 12th, 2021 - Folate deficiency can cause severe adverse pregnancy outcomes, such as neural tube defects. Effective folate functioning requires essential metabolic interactions with other B vitamins including vitamin B2, vitamin B3, vitamin B6, and vitamin B12,...

Periconceptional Surveillance in India
https://clinicaltrials.gov/ct2/show/NCT04048330

Nov 6th, 2020 - Women of reproductive age are a high-risk population for anemia and micronutrient deficiencies due to social structures, and the physical demands of pregnancy and lactation particularly in South Asia. Periconceptional vitamin B12 and folate status...

INAS-FOCUS (International Active Surveillance Study - Folate in Oral Contraceptives Utilization Study)
https://clinicaltrials.gov/ct2/show/NCT01266408

Jul 28th, 2020 - New oral contraceptives (OCs) containing drospirenone (DRSP) or dienogest (DNG)/ethinylestradiol (EE) plus levomefolate calcium (metafolin) have been recently introduced and will be introduced in a number of countries in the near future. Although ...

Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study
https://clinicaltrials.gov/ct2/show/NCT01365975

Mar 3rd, 2020 - Periconceptional folic acid supplements of 400 (Micro) daily prevent neural tube defects (NTD) in offspring. Some data suggest that periconceptional folic acid supplements, folate levels during pregnancy, and/or certain variants in the gene that e...

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News  147 results

Commercial Tests Offer Guidance in Bladder, Renal, Testicular Cancers
https://www.onclive.com/view/commercial-tests-offer-guidance-in-bladder-renal-testicular-cancers

Oct 6th, 2021 - Brian Rini, MD While biomarker-based tools designed to guide the diagnosis and treatment of prostate cancer are emerging at an extraordinarily rapid rate, they are not exploding in the same practice-changing way in all genitourinary cancers. The...

Folic Acid Being Added to Some Flour 
https://www.medscape.com/viewarticle/959047

Sep 20th, 2021 - Folic acid is to be added to non-wholemeal wheat flour across the UK to help reduce neural tube defects in babies by around 20%, or 200 cases a year. The decision follows a consultation in 2019 and is based on evidence of successful fortification ...

Paternal Preconception Alcohol Consumption Tied to Fetal Birth Defect Risk
https://www.medscape.com/viewarticle/949561

Apr 21st, 2021 - (Reuters Health) - Preconception paternal alcohol consumption is associated with an increased risk of fetal birth defects, driven by an elevated risk of clefts in particular, a Chinese study suggests. Researchers examined data on 529,090 couples p...

Folic Acid Supplementation Throughout Pregnancy: Neurocognitive Developmental Benefits for Children
https://www.medscape.com/viewarticle/948341

Mar 30th, 2021 - Takeaway Continued folic acid (FA) supplementation in pregnancy beyond the early period currently recommended to prevent neural tube defects (NTD) is beneficial to neurocognitive development in the child.

Another HIV Tivicay Birth Outcome: Better Infant Survival
https://www.medscape.com/viewarticle/947413

Mar 15th, 2021 - Infants born to women with HIV who were taking dolutegravir (DTG) plus emtracitabine/tenofovir alafenamide (FTC/TAF) had significantly higher odds of surviving the first 6 months after delivery than infants born to women taking efavirenz-based reg...

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Patient Education  8 results see all →