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ALLMedicine™ Restless Legs Syndrome Center

Research & Reviews  3,427 results

Accelerometer-measured physical activity and its impact on sleep quality in patients su...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908727
BMC Neurology; Reimers AK, Heidenreich V et. al.

Feb 26th, 2021 - The primary symptoms of restless legs syndrome (RLS) are sleep onset insomnia and difficulty to maintain sleep. Previous studies have shown that regular physical activity can reduce the risk of developing RLS. However, the relationship between phy...

Feasibility and efficacy of a physical activity intervention for managing restless legs...
https://doi.org/10.1016/j.msard.2021.102836
Multiple Sclerosis and Related Disorders; Cederberg KLJ, Motl RW

Feb 22nd, 2021 - This pilot randomized controlled trial examined the feasibility and efficacy of a physical activity behavior change intervention for improving restless legs syndrome (RLS) severity and secondary sleep outcomes among a sample of adults with multipl...

Effects of Cannabinoids on Sleep and their Therapeutic Potential for Sleep Disorders.
https://doi.org/10.1007/s13311-021-01013-w 10.3389/fpls.2019.00697 10.1016/j.ejim.2018.01.001 10.1523/JNEUROSCI.10-08-02541.1990 10.1152/jappl.1992.72.4.1221 10.1164/ajrccm/148.6_Pt_1.1610 10.1038/sj.ijo.0803272 10.1016/S0306-4522(96)00428-9 10.1038/365061a0 10.1016/S0167-4781(02)00341-X 10.1126/science.1115740 10.1016/j.pnpbp.2008.04.008 10.3389/fnint.2013.00040 10.1523/JNEUROSCI.22-20-08850.2002 10.1046/j.0022-3042.2002.00797.x 10.1152/jn.1995.73.2.907 10.1016/j.neuropharm.2011.02.016 10.1523/JNEUROSCI.3258-04.2005 10.1007/s11920-017-0775-9 10.1007/s40429-014-0016-9 10.1097/01.jcp.0000125688.05091.8f 10.1002/cpt1972133426 10.1016/0031-9384(73)90003-6 10.1016/0014-2999(73)90068-X 10.1037/pha0000126 10.1212/01.WNL.0000031422.66442.49 10.1037/0021-843X.112.3.393 10.1016/j.sleep.2010.02.013 10.1016/j.jsat.2017.07.012 10.1177/0269881112474524 10.1007/BF00497858 10.1016/j.drugalcdep.2020.107937 10.1016/j.brainres.2008.05.048 10.1523/JNEUROSCI.5838-09.2010 10.1016/j.lfs.2011.01.013 10.1371/journal.pone.0152473 10.1111/j.1476-5381.2010.00790.x 10.3389/fnmol.2020.00125 10.5664/jcsm.3358 10.3389/fnins.2018.00271 10.1210/clinem/dgaa028 10.5665/sleep.5546 10.1513/AnnalsATS.201212-127FR 10.1183/09031936.00065009 10.1056/NEJM197305102881902 10.33549/physiolres.932412 10.1016/j.neuropharm.2011.08.013 10.1093/jat/bks081 10.1213/ANE.0b013e3181c76f70 10.1002/cbdv.200790150 10.1136/bmjopen-2019-034421 10.1093/brain/awl163 10.1212/WNL.0b013e318294b3f6 10.1016/j.sleep.2014.05.019 10.1093/brain/awh441 10.1016/j.sleep.2017.04.019 10.1007/s11325-019-01978-1 10.1093/sleep/zsz067.475 10.1016/j.resp.2013.10.001 10.3928/00485713-20160125-01 10.1007/s40263-013-0051-4 10.5664/jcsm.27883 10.3389/fnins.2018.00502 10.1097/JCP.0000000000000180 10.1111/j.1755-5949.2008.00071.x 10.1016/j.psyneuen.2014.11.002 10.1007/s40261-014-0212-3 10.1007/s12035-016-9831-4 10.1111/jcpt.12179 10.1177/0269881108096519 10.1016/S0092-8674(00)81973-X 10.1002/cpt1975174458 10.1002/j.1552-4604.1981.tb02622.x 10.2174/1570159X11666131204235805 10.2174/1871527318666191021143300 10.1056/NEJMra1402309 10.5664/jcsm.7070 10.15288/jsad.2016.77.649 10.1016/j.smrv.2020.101339
Neurotherapeutics : the Journal of the American Society F... Kaul M, Zee PC et. al.

Feb 13th, 2021 - The recent trend for legalization of medicinal cannabis and cannabinoid-containing products, together with their soporific effects, has led to a surge of interest of their potential therapeutic role in the management of some common sleep disorders...

The seasonal pattern of restless legs syndrome in a sample from the Korean health insur...
https://www.ncbi.nlm.nih.gov/pubmed/33570488
Journal of Clinical Sleep Medicine : JCSM : Official Publ... Oh SM, Son KL et. al.

Feb 11th, 2021 - To assess the seasonality of restless legs syndrome (RLS) using data from the Korean national health insurance database. We retrospectively reviewed a randomly selected sample representing 3% of the national health insurance claims database in Sou...

Grey matter alterations in restless legs syndrome: A coordinate-based meta-analysis.
https://doi.org/10.1111/jsr.13298
Journal of Sleep Research; Sheng L, Zhao P et. al.

Feb 8th, 2021 - Brain structural abnormalities in idiopathic restless legs syndrome have long been debated. Voxel-based morphometry is an objective structural magnetic resonance imaging technique to investigate regional grey matter volume or density differences b...

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Guidelines  4 results

Iron for the treatment of restless legs syndrome
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007834.pub3/abstract
The Cochrane Database of Systematic Reviews; Trotti,L.,et al

Jan 3rd, 2019 - Restless legs syndrome (RLS) is a common neurologic disorder that is associated with peripheral iron deficiency in a subgroup of patients. It is unclear whether iron therapy is effective treatment for RLS. Objectives To evaluate the efficacy and ...

Consensus clinical practice guidelines for the diagnosis and treatment of restless legs...
https://doi.org/10.1016/j.smrv.2014.10.009
Sleep Medicine Reviews; Picchietti DL, Hensley JG et. al.

Jan 2nd, 2015 - Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is common during pregnancy, affecting approximately one in five pregnant women in Western countries. Many report moderate or severe symptoms and negative impact on sleep. There is very little...

European guidelines on management of restless legs syndrome: report of a joint task for...
https://doi.org/10.1111/j.1468-1331.2012.03853.x
European Journal of Neurology; Garcia-Borreguero D, Ferini-Strambi L et. al.

Sep 3rd, 2012 - Since the publication of the first European Federation of Neurological Societies (EFNS) guidelines in 2005 on the management of restless legs syndrome (RLS; also known as Willis-Ekbom disease), there have been major therapeutic advances in the fie...

The treatment of restless legs syndrome and periodic limb movement disorder in adults--...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397811
Sleep Aurora RN, Kristo DA et. al.

Aug 1st, 2012 - A systematic literature review and meta-analyses (where appropriate) were performed to update the previous AASM practice parameters on the treatments, both dopaminergic and other, of RLS and PLMD. A considerable amount of literature has been publi...

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Drugs  161 results see all →

Clinicaltrials.gov  3,771 results

Accelerometer-measured physical activity and its impact on sleep quality in patients su...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908727
BMC Neurology; Reimers AK, Heidenreich V et. al.

Feb 26th, 2021 - The primary symptoms of restless legs syndrome (RLS) are sleep onset insomnia and difficulty to maintain sleep. Previous studies have shown that regular physical activity can reduce the risk of developing RLS. However, the relationship between phy...

Feasibility and efficacy of a physical activity intervention for managing restless legs...
https://doi.org/10.1016/j.msard.2021.102836
Multiple Sclerosis and Related Disorders; Cederberg KLJ, Motl RW

Feb 22nd, 2021 - This pilot randomized controlled trial examined the feasibility and efficacy of a physical activity behavior change intervention for improving restless legs syndrome (RLS) severity and secondary sleep outcomes among a sample of adults with multipl...

Effects of Cannabinoids on Sleep and their Therapeutic Potential for Sleep Disorders.
https://doi.org/10.1007/s13311-021-01013-w 10.3389/fpls.2019.00697 10.1016/j.ejim.2018.01.001 10.1523/JNEUROSCI.10-08-02541.1990 10.1152/jappl.1992.72.4.1221 10.1164/ajrccm/148.6_Pt_1.1610 10.1038/sj.ijo.0803272 10.1016/S0306-4522(96)00428-9 10.1038/365061a0 10.1016/S0167-4781(02)00341-X 10.1126/science.1115740 10.1016/j.pnpbp.2008.04.008 10.3389/fnint.2013.00040 10.1523/JNEUROSCI.22-20-08850.2002 10.1046/j.0022-3042.2002.00797.x 10.1152/jn.1995.73.2.907 10.1016/j.neuropharm.2011.02.016 10.1523/JNEUROSCI.3258-04.2005 10.1007/s11920-017-0775-9 10.1007/s40429-014-0016-9 10.1097/01.jcp.0000125688.05091.8f 10.1002/cpt1972133426 10.1016/0031-9384(73)90003-6 10.1016/0014-2999(73)90068-X 10.1037/pha0000126 10.1212/01.WNL.0000031422.66442.49 10.1037/0021-843X.112.3.393 10.1016/j.sleep.2010.02.013 10.1016/j.jsat.2017.07.012 10.1177/0269881112474524 10.1007/BF00497858 10.1016/j.drugalcdep.2020.107937 10.1016/j.brainres.2008.05.048 10.1523/JNEUROSCI.5838-09.2010 10.1016/j.lfs.2011.01.013 10.1371/journal.pone.0152473 10.1111/j.1476-5381.2010.00790.x 10.3389/fnmol.2020.00125 10.5664/jcsm.3358 10.3389/fnins.2018.00271 10.1210/clinem/dgaa028 10.5665/sleep.5546 10.1513/AnnalsATS.201212-127FR 10.1183/09031936.00065009 10.1056/NEJM197305102881902 10.33549/physiolres.932412 10.1016/j.neuropharm.2011.08.013 10.1093/jat/bks081 10.1213/ANE.0b013e3181c76f70 10.1002/cbdv.200790150 10.1136/bmjopen-2019-034421 10.1093/brain/awl163 10.1212/WNL.0b013e318294b3f6 10.1016/j.sleep.2014.05.019 10.1093/brain/awh441 10.1016/j.sleep.2017.04.019 10.1007/s11325-019-01978-1 10.1093/sleep/zsz067.475 10.1016/j.resp.2013.10.001 10.3928/00485713-20160125-01 10.1007/s40263-013-0051-4 10.5664/jcsm.27883 10.3389/fnins.2018.00502 10.1097/JCP.0000000000000180 10.1111/j.1755-5949.2008.00071.x 10.1016/j.psyneuen.2014.11.002 10.1007/s40261-014-0212-3 10.1007/s12035-016-9831-4 10.1111/jcpt.12179 10.1177/0269881108096519 10.1016/S0092-8674(00)81973-X 10.1002/cpt1975174458 10.1002/j.1552-4604.1981.tb02622.x 10.2174/1570159X11666131204235805 10.2174/1871527318666191021143300 10.1056/NEJMra1402309 10.5664/jcsm.7070 10.15288/jsad.2016.77.649 10.1016/j.smrv.2020.101339
Neurotherapeutics : the Journal of the American Society F... Kaul M, Zee PC et. al.

Feb 13th, 2021 - The recent trend for legalization of medicinal cannabis and cannabinoid-containing products, together with their soporific effects, has led to a surge of interest of their potential therapeutic role in the management of some common sleep disorders...

The seasonal pattern of restless legs syndrome in a sample from the Korean health insur...
https://www.ncbi.nlm.nih.gov/pubmed/33570488
Journal of Clinical Sleep Medicine : JCSM : Official Publ... Oh SM, Son KL et. al.

Feb 11th, 2021 - To assess the seasonality of restless legs syndrome (RLS) using data from the Korean national health insurance database. We retrospectively reviewed a randomly selected sample representing 3% of the national health insurance claims database in Sou...

Ropinirole - ropinirole tablet, film coated-Marlex Pharmaceuticals Inc
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=35d90f6f-3116-4afa-be2d-b65c160e8ab3

Feb 11th, 2021 - Ropinirole tablet is a non-ergoline dopamine agonist indicated for the treatment of Parkinson’s disease (PD) and moderate- to-severe primary Restless Legs Syndrome (RLS). ( 1.1, 1.2) Ropinirole tablets are indicated for the treatment of Parkinson’...

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News  289 results

Rapid Weight Gain in an Excessively Sleepy Girl With Asthma
https://reference.medscape.com/viewarticle/938423_3

Oct 8th, 2020 - Discussion This case is very challenging because the patient had the findings of and met the criteria for OSA, periodic limb movement disorder (PLMD)/restless legs syndrome (RLS), and hypersomnolence. She also had several historical findings that ...

Fast Five Quiz: Sleep Disorders
https://reference.medscape.com/viewarticle/934767_1

Aug 2nd, 2020 - Difficulty with sleep is common, with some studies showing as many as 1 in 3 individuals report some type of sleep disorder. Reduced sleep duration has been linked to almost half of the 15 leading causes of death in the United States. From poor pe...

Fast Five Quiz: Sleep Disorders
https://reference.medscape.com/viewarticle/934767

Aug 2nd, 2020 - Difficulty with sleep is common, with some studies showing as many as 1 in 3 individuals report some type of sleep disorder. Reduced sleep duration has been linked to almost half of the 15 leading causes of death in the United States. From poor pe...

Data point to bidirectional link between sleep disorders and ADHD
https://www.mdedge.com/pediatrics/article/214815/sleep-medicine/data-point-bidirectional-link-between-sleep-disorders-and?channel=39313
Christine Kilgore

Dec 30th, 2019 - Insomnia, restless legs syndrome (RLS), and frequent snoring were significantly associated with subsequent ADHD symptoms in a large longitudinal study of adolescents in China. Investigators twice assessed 7,072 middle and high school students part.

FDA warns gabapentin, pregabalin may cause serious breathing problems
https://www.mdedge.com/neurology/article/214607/epilepsy-seizures/fda-warns-gabapentin-pregabalin-may-cause-serious?channel=27979
Jake Remaly

Dec 19th, 2019 - Gabapentin and pregabalin are associated with serious breathing problems when used with central nervous system depressants or in patients with lung problems, according to a Dec. 19 drug safety alert from the Food and Drug Administration.

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Patient Education  23 results see all →