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About 960 results

ALLMedicine™ Epileptic Encephalopathies Center

Research & Reviews  352 results

The effectiveness and tolerability of clobazam in the pediatric population: Adjunctive ...
https://doi.org/10.1016/j.eplepsyres.2022.106963
Epilepsy Research; Kamaşak T, Serdaroğlu E et. al.

Jun 25th, 2022 - To evaluate the effectiveness and tolerability of clobazam therapy in the pediatric population in terms of seizure semiology, epileptic syndromes, and etiological subgroups. A retrospective cohort study was conducted consisting of 1710 epileptic c...

Impact of Genetic Testing on Therapeutic Decision-Making in Childhood-Onset Epilepsies-...
https://doi.org/10.1007/s13311-022-01264-1
Neurotherapeutics : the Journal of the American Society F... Bayat A, Fenger CD et. al.

Jun 21st, 2022 - We assessed the frequency of pediatric monogenic epilepsies and precision therapies at a tertiary epilepsy center. We analyzed medical records of children, born in 2006-2011 and followed at the Danish Epilepsy Center from January to December 2015;...

The role of common genetic variation in presumed monogenic epilepsies.
https://doi.org/10.1016/j.ebiom.2022.104098
EBioMedicine Campbell C, Leu C et. al.

Jun 10th, 2022 - The developmental and epileptic encephalopathies (DEEs) are the most severe group of epilepsies which co-present with developmental delay and intellectual disability (ID). DEEs usually occur in people without a family history of epilepsy and have ...

Possible critical region associated with late-onset spasms in 17p13.1-p13.2 microdeleti...
https://doi.org/10.1684/epd.2022.1416
Epileptic Disorders : International Epilepsy Journal With... Yamamoto N, Okazaki S et. al.

Jun 3rd, 2022 - 17p13.1-2 microdeletion syndrome is a congenital anomaly syndrome with characteristic facial features and multiple malformations. The prevalence of epilepsy with 17p13.1-2 microdeletion is low, with only one case reported for late-onset spasms. La...

Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies
https://clinicaltrials.gov/ct2/show/NCT05364021

May 19th, 2022 - This is a randomized, double-blind, parallel-group, dose-escalation, placebo-controlled study of LP352 in adults with developmental and epileptic encephalopathies (DEE) with an average of ≥ 4 observed/countable motor seizures per 4-week period dur...

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Clinicaltrials.gov  13 results

Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies
https://clinicaltrials.gov/ct2/show/NCT05364021

May 19th, 2022 - This is a randomized, double-blind, parallel-group, dose-escalation, placebo-controlled study of LP352 in adults with developmental and epileptic encephalopathies (DEE) with an average of ≥ 4 observed/countable motor seizures per 4-week period dur...

Natural History Study of Infants and Children With Developmental and Epileptic Encephalopathies
https://clinicaltrials.gov/ct2/show/NCT04537832

May 16th, 2022 - This prospective, longitudinal, natural history master protocol has been designed to define the seizure, neurodevelopmental, and behavioral characteristics of SCN1A-positive Dravet Syndrome in infants and children between 6 and 60 months. It will ...

Fenfluramine for the Treatment of Different Types of Developmental and Epileptic Encephalopathies: a Pilot Trial Exploring Epileptic and Non-epileptic Outcomes
https://clinicaltrials.gov/ct2/show/NCT05232630

Mar 16th, 2022 - This study is a pilot non-controlled clinical trial with adjunctive fenfluramine for the treatment of five different types of developmental and epileptic encephalopathies (DEEs) focused on epileptic and "non-epileptic outcomes": SYNGAP1 and STXBP1...

Long-term Cardiac Monitoring in Epilepsy
https://clinicaltrials.gov/ct2/show/NCT03955432

Nov 17th, 2021 - Most cardiac studies have investigated patients with intractable focal epilepsy who have a high risk for co-morbidities, accidents, injury and SUDEP. This is confounded by the major antiepileptic drug burden in this population. Very little, howeve...

Cannabidiol in Children With Refractory Epileptic Encephalopathy
https://clinicaltrials.gov/ct2/show/NCT03024827

Sep 28th, 2021 - Epileptic Encephalopathies are a group of epilepsies that develop in children. These epilepsies can cause frequent and difficult to control seizures. Because of the ongoing seizures, these epilepsies can also cause cognitive impairment and neurolo...

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News  19 results

FDA Okays New Med for Lennox-Gastaut Syndrome
https://www.medscape.com/viewarticle/971158

Mar 29th, 2022 - The US Food and Drug Administration (FDA) has approved fenfluramine (Fintepla) oral solution, a Schedule IV controlled substance, for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in children aged 2 years and older, the c...

CBD Gel a Promising Adjunct for Kids With Severe Epilepsy
https://www.medscape.com/viewarticle/958889

Sep 16th, 2021 - Topical cannabidiol (CBD) gel, added to antiseizure medication, may help reduce seizures and improve quality of life in children with developmental and epileptic encephalopathies, according to the results of a nonrandomized controlled trial. Devel...

Rare Pediatric Diseases Special Report 2019
https://www.mdedge.com/pediatrics/article/211163/rare-diseases/rare-pediatric-diseases-special-report-2019

Oct 29th, 2019 - The Rare Pediatric Diseases Special Report is a supplement to Pediatric News that discusses advancements in the treatment of rare pediatric neuromuscular disorders like spinal muscular atrophy, Duchenne muscular dystrophy, and X-linked myotubular.

Ketogenic diets are what’s cooking for drug-refractory epilepsy
https://www.mdedge.com/familymedicine/article/206419/epilepsy-seizures/ketogenic-diets-are-whats-cooking-drug-refractory
Clinical Neurology News; Bruce Jancin

Aug 14th, 2019 - BANGKOK – For a form of epilepsy treatment that’s been around since the 1920s, ketogenic diet therapy has lately been the focus of a surprising wealth of clinical research and development, Suvasini Sharma, MD, observed at the International Epileps.

Well-Controlled Epilepsy Also Tied to Sudden Death
https://www.medscape.com/viewarticle/914617

Jun 19th, 2019 - Although people with refractory epilepsy, including some with frequent, ongoing convulsive seizures, are at high risk for sudden unexpected death in epilepsy (SUDEP), a large North American registry study reveals that even those with well-controll...

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