ALLMedicine™ Epileptic Encephalopathies Center

Dec 2nd, 2021 - Epilepsy is the neurological disorder defined by spontaneous recurrent seizures, which are abnormal patterns of electrical discharge in the brain. A major advance in neurology over the last 20 years is the identification of genetic variation as an...

Nov 18th, 2021 - FZR1, which encodes the Cdh1 subunit of the Anaphase Promoting Complex, plays an important role in neurodevelopment by regulating the cell cycle and by its multiple post-mitotic functions in neurons. In this study, evaluation of 250 unrelated pati...

Nov 12th, 2021 - Ketogenic diet therapy (KDT) is a metabolic treatment with proven effectiveness for the treatment of drug-resistant epilepsy in children. Although previously not used in infants under 2 years of age, recent studies have shown KDT to be highly effe...

Nov 10th, 2021 - This seminar in epileptology addresses Learning Objective 6.1.4 of the International League against Epilepsy Curriculum: Demonstrate the ability to recognize and manage the special needs of persons with epilepsy (and Neurodevelopmental Disorders [...

Nov 5th, 2021 - To determine whether whole genome sequencing can be used to define the molecular basis of suspected mitochondrial disease. Cohort study. National Health Service, England, including secondary and tertiary care. 345 patients with suspected mitochond...

Mar 17th, 2021 - Electrical activity emerges in the third trimester of pregnancy, plays an important role in the construction of cortical maps, and is impaired in patients with severe early epileptic encephalopathies (EOEE). EOEE are rare and severe epileptic synd...

Feb 18th, 2021 - The drug being tested in this study is called TAK-935 (OV935). This randomized, double-blind study will assess the effects of TAK-935 (OV935), compared to placebo, on efficacy, safety, and tolerability in pediatric participants with Dravet syndrom...

Aug 29th, 2018 - Congenital epileptic encephalopathies (EE) are predominantly genetic in origin. Their diagnosis is hampered by the large number of genes involved and their low recurrence. Genetic study in routine diagnosis is limited by the existing techniques an...

Aug 31st, 2016 - Infantile Spasms syndrome (ISs) is a characterized by epileptic spasms occurring in clusters with an onset in the first year of life. West syndrome represents a subset of ISs that associates spasms in clusters, a hypsarrhythmia EEG pattern and a d...

Sep 16th, 2021 - Topical cannabidiol (CBD) gel, added to antiseizure medication, may help reduce seizures and improve quality of life in children with developmental and epileptic encephalopathies, according to the results of a nonrandomized controlled trial. Devel...

Aug 14th, 2019 - BANGKOK – For a form of epilepsy treatment that’s been around since the 1920s, ketogenic diet therapy has lately been the focus of a surprising wealth of clinical research and development, Suvasini Sharma, MD, observed at the International Epileps.

Jun 19th, 2019 - Although people with refractory epilepsy, including some with frequent, ongoing convulsive seizures, are at high risk for sudden unexpected death in epilepsy (SUDEP), a large North American registry study reveals that even those with well-controll...

Dec 3rd, 2018 - NEW ORLEANS – A synthetic, transdermal, cannabidiol gel reduced the rate of seizures by half in a group of adults with treatment-resistant focal seizures who were participating in an open-label, long-term extension trial. Michele G.

Jun 26th, 2017 - Jacqueline A. French, MD BOSTON—There is no such thing as a one-size-fits-all approach to epilepsy therapy, according to an overview presented at the 69th Annual Meeting of the American Academy of Neurology.