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About 2,980 results

ALLMedicine™ Chordoma Center

Research & Reviews  1,467 results

Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile ...
https://doi.org/10.3171/2021.2.FOCUS201059
Neurosurgical Focus; Pennington Z, Ehresman J et. al.

May 1st, 2021 - Long-term local control in patients with primary chordoma and sarcoma of the spine and sacrum is increasingly reliant upon en bloc resection with negative margins. At many institutions, adjuvant radiation is recommended; definitive radiation is al...

Targeted Therapy for Chordoma: Key Molecular Signaling Pathways and the Role of Multimo...
https://doi.org/10.1007/s11523-021-00814-5 10.1007/s11060-021-03742-6
Targeted Oncology; Akinduro OO, Suarez-Meade P et. al.

Apr 24th, 2021 - Chordoma is a rare but devastating tumor that arises in the cranial skull base or spine. There are currently no US Food and Drug Administration-approved targeted therapies for chordoma, and little understanding of whether using more than one thera...

Sacral chordoma with incidental rectal adenocarcinoma: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040199
Journal of Medical Case Reports; Alshahri J, Alshehri M et. al.

Apr 13th, 2021 - We report a unique case of synchronous sacrococcygeal chordoma in association with rectal invasive adenocarcinoma. Retrorectal tumors are a rare disease caused by a variety of pathologies. To our knowledge, no prior cases of such a coincidental fi...

LncRNA-NONHSAT024778 promote the proliferation and invasion of chordoma cell by regulat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975704
International Journal of Biological Sciences; Wang B, Zhang K et. al.

Mar 26th, 2021 - Chordoma is a malignant bone tumor originating from the embryonic remnants of the notochord. lncRNAs act as competing endogenous RNAs (ceRNAs) and play a critical role in tumor pathology. However, the biological role of lncRNA-NONHSAT024778 and th...

Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in hum...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949631
International Journal of Oncology; Yang J, Huang H et. al.

Mar 24th, 2021 - Chordoma is a rare low‑grade tumor of the axial skeleton. Over previous decades, a range of targeted drugs have been used for treating chordoma, with more specific and effective therapies under investigation. Transmembrane Emp24 protein transport ...

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Guidelines  2 results

NCCN Guidelines Insights: Bone Cancer, Version 2.2017
http://www.jnccn.org/content/15/2/155.full
Biermann, J.,et al

Jan 31st, 2017 - The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations for treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and osteosarcoma. These NCCN Guidelines Insights summarize the NCCN Bone Cancer Panel's g.

Bone cancer.
https://doi.org/10.6004/jnccn.2013.0088
Journal of the National Comprehensive Cancer Network : JN... Biermann JS, Adkins DR et. al.

Jun 7th, 2013 - Primary bone cancers are extremely rare neoplasms, accounting for fewer than 0.2% of all cancers. The evaluation and treatment of patients with bone cancers requires a multidisciplinary team of physicians, including musculoskeletal, medical, and r...

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Clinicaltrials.gov  1,491 results

Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile ...
https://doi.org/10.3171/2021.2.FOCUS201059
Neurosurgical Focus; Pennington Z, Ehresman J et. al.

May 1st, 2021 - Long-term local control in patients with primary chordoma and sarcoma of the spine and sacrum is increasingly reliant upon en bloc resection with negative margins. At many institutions, adjuvant radiation is recommended; definitive radiation is al...

Targeted Therapy for Chordoma: Key Molecular Signaling Pathways and the Role of Multimo...
https://doi.org/10.1007/s11523-021-00814-5 10.1007/s11060-021-03742-6
Targeted Oncology; Akinduro OO, Suarez-Meade P et. al.

Apr 24th, 2021 - Chordoma is a rare but devastating tumor that arises in the cranial skull base or spine. There are currently no US Food and Drug Administration-approved targeted therapies for chordoma, and little understanding of whether using more than one thera...

Sacral chordoma with incidental rectal adenocarcinoma: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040199
Journal of Medical Case Reports; Alshahri J, Alshehri M et. al.

Apr 13th, 2021 - We report a unique case of synchronous sacrococcygeal chordoma in association with rectal invasive adenocarcinoma. Retrorectal tumors are a rare disease caused by a variety of pathologies. To our knowledge, no prior cases of such a coincidental fi...

LncRNA-NONHSAT024778 promote the proliferation and invasion of chordoma cell by regulat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975704
International Journal of Biological Sciences; Wang B, Zhang K et. al.

Mar 26th, 2021 - Chordoma is a malignant bone tumor originating from the embryonic remnants of the notochord. lncRNAs act as competing endogenous RNAs (ceRNAs) and play a critical role in tumor pathology. However, the biological role of lncRNA-NONHSAT024778 and th...

Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in hum...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949631
International Journal of Oncology; Yang J, Huang H et. al.

Mar 24th, 2021 - Chordoma is a rare low‑grade tumor of the axial skeleton. Over previous decades, a range of targeted drugs have been used for treating chordoma, with more specific and effective therapies under investigation. Transmembrane Emp24 protein transport ...

see more →

News  11 results

FDA places tazemetostat trials on partial hold
https://www.mdedge.com/hematology-oncology/article/184994/lymphoma-plasma-cell-disorders/fda-places-tazemetostat-trials-partial-hold
HT Staff

Apr 25th, 2018 - The US Food and Drug Administration (FDA) has placed a partial hold on clinical trials of tazemetostat, an EZH2 inhibitor being developed to treat solid tumors and lymphomas. The hold has halted enrollment in US-based trials of tazemetostat, but s.

Treating Bone and Soft Tissue Sarcomas
https://www.onclive.com/publications/oncology-live/2015/october-2015/treating-bone-and-soft-tissue-sarcomas

Oct 15th, 2015 - Jonathan C. Trent, MD, PhD Breelyn A. Wilky, MD Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami, FL Determining the best course of treatment for sarcomas of the bone and soft tissues is a complex process. ...

New Guidelines for Chordoma
https://www.mdedge.com/neurology/article/98601/new-guidelines-chordoma

Apr 8th, 2015 - Patients with chordoma, caregivers, and health care professionals have a new resource to aid in their fight against chordoma, with the publication of the first detailed, multidisciplinary treatment guidelines in the journal The Lancet Oncology. Th.

New guidelines for chordoma
https://www.mdedge.com/neurology/article/98606/rare-diseases/new-guidelines-chordoma

Apr 8th, 2015 - Chordoma patients, caregivers, and health care professionals have a new resource to aid in their fight against chordoma, with the publication of the first detailed, multidisciplinary treatment guidelines in the journal The Lancet Oncology. These r.

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Patient Education  9 results see all →