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Pipeline Flex Embolization Device

Access product information about the Pipeline Flex embolization device, which redefines treatment for large or giant wide-necked aneurysms by diverting flow away from the aneurysm neck and by reconstructing the parent artery and restoring its natural course.

Faulty Amino Acid Metabolism Linked to Rare Eye Disease

Sep 12th, 2019 - A defect in serine metabolism was found to be behind a rare macular disease, according to researchers reporting a new connection between central and peripheral neuropathies. Genetic mutations in SPTLC1 and SPTLC2, known to cause hereditary sensory and autonomic neuropathy type 1 (HSAN1), were also tied to macular telangiectasia type 2 from exome sequencing, according to a report by Martin Fried...

LVAD-Related GI Bleeding: Another Reason to Take Heart Failure Drugs

Apr 8th, 2019 - Angiotensin II antagonists may help prevent GI bleeding among heart failure patients with continuous-flow left ventricular assist devices (LVADs), a retrospective study suggested. Taking ACE inhibitors or angiotensin receptor blockers (ARBs) at any point within the first 30 days following LVAD placement was associated with a reduced subsequent risk of major GI bleeds (15% vs 31%, adjusted HR 0....

Medtronic in $31 Million Settlement With DOJ Over Medical Devices

Dec 5th, 2018 - Two companies now owned by Medtronic have agreed to pay a total of $31 million to resolve US Department of Justice (DOJ) charges involving marketing violations and kickback schemes. Medical device maker ev3 has agreed to plead guilty to charges related to its neurovascular medical device Onyx Liquid Embolic System and pay $17.9 million, the DOJ said. The US Food and Drug Administration (FDA) ap...

The Rest of the Story on Vitamin B for Stroke Prevention

Oct 17th, 2018 - It is clear that high levels of total homocysteine (tHcy) are a strong, graded risk factor for vascular disease. This is particularly true for cardioembolic stroke; high levels of tHcy quadruple the risk of stroke in atrial fibrillation. Vitamin therapy with folic acid, B6, and B12 can lower levels of tHcy, so it was logical to think that they should reduce the risk of cardiovascular events. No...

Prevention of Cardioembolic Stroke in Obese Patients With Nonvalvular Atrial Fibrillation

Sep 30th, 2018 - This article is republished with permission from the ACC. For more, see www.ACC.org. Ms. X is a 70-year-old female with new onset non-valvular atrial fibrillation. She has a past medical history of hypertension, diabetes, hyperlipidemia and morbid obesity. BMI 43.7 kg/m2, 123 kg, 66 inches. CrCl 45 mL/min. There are no pertinent drug interactions.

Consider Atrial Fibrillation in Patients With Stroke and Obstructive Sleep Apnea

Sep 27th, 2018 - A Single-Center Study Researchers at Mayo Clinic compared strokes in patients with and without OSA. They examined data from patients who had their first ischemic stroke within one year after undergoing polysomnography.

Review: Common gastrointestinal conditions in people living with HIV/AIDS
Lucas Franki, MDedge News

Jan 10th, 2018 - The two most common gastrointestinal conditions reported by people living with HIV/AIDS are diarrhea and nausea, according to Vincent Hall, PhD. Diarrhea has been reported in up to 60% of people living with HIV/AIDS, and is generally classified as being infectious or noninfectious.

KRAS Mutation Found in Brain Arteriovenous Malformations

Jan 9th, 2018 - Researchers have identified a genetic mutation in patients with an arteriovenous malformation (AVM) of the brain, a leading cause of hemorrhagic stroke in young adults and children. Results of their new study suggest that these malformations are a result of KRAS-induced activation of the mitogen-activated protein kinase–extracellular signal-regulated kinase (MAPK-ERK) signaling pathway in brain...

Genetic Mutation May Underlie AV Malformations

Jan 4th, 2018 - Action Points Note that this observational study found a high rate of KRAS mutations in tissue samples of brain arteriovenous malformations. Be aware that these mutations were not detected in peripheral blood, suggesting they are acquired at some point during life. Arteriovenous malformations of the brain may arise due to a genetic mutation, acquired later in life, that activates a cellular sig...

New European Guidelines for Cerebral Venous Thrombosis

Sep 14th, 2017 - New guidelines for the diagnosis and treatment of cerebral venous thrombosis (CVT) have been issued by the European Stroke Organisation. The guidelines, published in the European Journal of Neurology, have also been endorsed by the European Academy of Neurology.  "There has been a lot of uncertainty about the best treatments for CVT and several therapies used are unproven with little safety dat...

Cerebral Venous Thrombosis

Jul 14th, 2017 - The case discussed here illustrates the clinical presentation and diagnostic complexities of CVT. Two days before coming to the ED, the patient presented to an outside facility and underwent a workup for nonspecific symptoms (eg, confusion, headaches).

July 2017 Digital Edition

Jul 1st, 2017 - Click here to access the July 2017 Digital Edition. Table of Contents Nonpathologic Postdeployment Transition Symptoms in Combat National Guard Members and Reservists Sarcopenia and the New ICD-10-CM Code: Screening, Staging, and Diagnosis Considerations Cerebral Venous Thrombosis Peer Support for Whistleblowers Symptoms Mimicking Those of Hypokalemic Periodic Paralysis Induced by Soluble Bariu.

Rupture Risk Low for Small Cerebral Aneurysms

Jun 5th, 2017 - Small intracranial aneurysms have a low risk for growth and rupture, and very small aneurysms have an even lower risk, although the quality of the evidence is not ideal, results of a new systematic review suggest. "The evidence is poor, but we are making clinical decisions based on this very same evidence," lead author, Ajay Malhotra, MD, associate professor, Department of Radiology and Biomedi...

CV Autonomic Neuropathy Predicts CVD in Type 1 Diabetes

Nov 17th, 2016 - Cardiovascular autonomic neuropathy (CAN) is associated with cardiovascular events in type 1 diabetes, new research shows. The findings, from 1251 participants in the randomized Diabetes Control and Complications Trial (DCCT) and its observational follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study, were published online November 1 in Diabetes Care by Rodica Pop-Busu...

Statement Offers Guidance for Management of Brain AVMs
Jan Dyer

Jul 7th, 2016 - Recent studies have helped clarify the natural history risks of intracranial hemorrhage (ICH) and seizure in patients with unruptured brain arteriovenous malformations (AVMs). In addition, researchers have completed the first randomized trial of interventional therapy versus conservative management for unruptured brain AVMs.

Obesity Ups Cerebral Venous Thrombosis Risk in Women on OCs

Mar 15th, 2016 - Women who are obese and are taking oral contraceptives have a significantly increased risk for cerebral venous thrombosis (CVT), a new study suggests. The study, published online in JAMA Neurology on March 14, was conducted by a group led by Jonathan M. Coutinho, MD, Academic Medical Centre, Amsterdam, the Netherlands. He explained to Medscape Medical News that CVT is a severe disease — much mo...

Overweight, Oral Contraceptives Tied to Higher Risk of Cerebral VT

Mar 15th, 2016 - Action Points Note that this observational study found that among overweight and obese women, the use of oral contraceptives was associated with increased risk of central venous thrombosis. Be aware that the overall absolute risk was quite low. Women who are overweight or obese and using oral contraceptives had a significantly increased risk of cerebral venous thrombosis (CVT) compared with wom...

Some Obese Women Carry Increased Risk of Cerebral Venous Thrombosis

Mar 14th, 2016 - NEW YORK (Reuters Health) - Obese women who take oral contraceptives face a markedly increased risk of cerebral venous thrombosis (CVT), according to results from a case-control study in the Netherlands and Switzerland. "Physicians should have a lower threshold of suspecting CVT in an obese woman who uses oral contraceptives if they present with symptoms such as severe headache, focal neurologi...

Obesity, oral contraceptive use are risk factors for cerebral venous thrombosis in women
Heidi Splete

Mar 14th, 2016 - Obese women taking oral contraceptives had a 30-fold increased odds for cerebral venous thrombosis (CVT), compared with normal-weight women, in an unmatched case-control study of 186 CVT cases and 6,134 controls. The association between a body-mass index of 30 kg/m2 or higher and increased odds of CVT “appears to be fully attributable to a strongly increased risk in women who use oral contracep.