Lip, G.,et al.
Nov 27th, 2018 - The risk of stroke is heterogeneous across different groups of patients with atrial fibrillation (AF), being dependent on the presence of various stroke risk factors. We provide recommendations for antithrombotic treatment based on net clinical benefit for patients with AF at varying levels of stroke risk and in a number of common clinical scenarios.
Biermann, J.,et al
Jan 31st, 2017 - The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations for treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and osteosarcoma. These NCCN Guidelines Insights summarize the NCCN Bone Cancer Panel's guideline recommendations for treating Ewing sarcoma.
The National Craniofacial Association
Feb 11th, 2016 - Description of Hydrocephalus aimed at helping parents understand the condition and the treatment that may be required. Provides list of additional resources.
D. Scott Kreiner
Dec 31st, 2013 - The objective of the North American Spine Society (NASS) Clinical Guideline for the Diagnosis and Treatment of Lumbar Disc Herniation with Radiculopathy is to provide evidence-based recommendations to address key clinical questions surrounding the diagnosis and treatment of lumbar disc herniation with radiculopathy. The guideline is intended to reflect contemporary treatment concepts for sympto.
JAMA Miller PD, Hattersley G et. al.
Aug 17th, 2016 - Additional therapies are needed for prevention of osteoporotic fractures. Abaloparatide is a selective activator of the parathyroid hormone type 1 receptor. To determine the efficacy and safety of abaloparatide, 80 μg, vs placebo for prevention of new vertebral fracture in postmenopausal women at risk of osteoporotic fracture. The Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) w...
The New England Journal of Medicine; Johnston SC, Amarenco P et. al.
May 10th, 2016 - Ticagrelor may be a more effective antiplatelet therapy than aspirin for the prevention of recurrent stroke and cardiovascular events in patients with acute cerebral ischemia. We conducted an international double-blind, controlled trial in 674 centers in 33 countries, in which 13,199 patients with a nonsevere ischemic stroke or high-risk transient ischemic attack who had not received intravenou...
Neurology Jaraj D, Agerskov S et. al.
Jan 16th, 2016 - We examined clinical and imaging findings of suspected idiopathic normal pressure hydrocephalus (iNPH) in relation to vascular risk factors and white matter lesions (WMLs), using a nested case-control design in a representative, population-based sample. From a population-based sample, 1,235 persons aged 70 years or older were examined with CT of the brain between 1986 and 2000. We identified 55...
The Lancet. Neurology; Kazui H, Miyajima M et. al.
May 2nd, 2015 - Lumboperitoneal shunt surgery has the potential to alleviate symptoms of normal pressure hydrocephalus but the benefits of such surgery have not been tested in a randomised trial. The aim of this trial was to determine the safety and efficacy of the lumboperitoneal shunt surgery for this disorder. For the open-label randomised SINPHONI-2 trial, eligible participants (60-85 years of age) with id...
Lancet (London, England); Molyneux AJ, Birks J et. al.
Dec 3rd, 2014 - Previous analyses of the International Subarachnoid Aneurysm Trial (ISAT) cohort have reported on the risks of recurrent subarachnoid haemorrhage and death or dependency for a minimum of 5 years and up to a maximum of 14 years after treatment of a ruptured intracranial aneurysm with either neurosurgical clipping or endovascular coiling. At 1 year there was a 7% absolute and a 24% relative risk ...
The New England Journal of Medicine; Wilson MR, Naccache SN et. al.
Jun 4th, 2014 - A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 se...
Lancet (London, England); Mallucci CL, Jenkinson MD et. al.
Sep 16th, 2019 - Insertion of a ventriculoperitoneal shunt for hydrocephalus is one of the commonest neurosurgical procedures worldwide. Infection of the implanted shunt affects up to 15% of these patients, resulting in prolonged hospital treatment, multiple surgeries, and reduced cognition and quality of life. Our aim was to determine the clinical and cost-effectiveness of antibiotic (rifampicin and clindamyci...
JAMA Neurology; Ferro JM, Coutinho JM et. al.
Sep 3rd, 2019 - Patients with cerebral venous thrombosis (CVT) are at risk of recurrent venous thrombotic events (VTEs). Non-vitamin K oral anticoagulants have not been evaluated in randomized controlled trials in CVT. To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT. RE-SPECT CVT is an explorator...
Stroke Altavilla R, Caso V et. al.
Jun 21st, 2019 - Background and Purpose- Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of a higher incidence of intracerebral bleeding. However, this practice is common in clinical settings. This observational study aimed to compare (1) the clinical profiles of patients receiving and not receiving bridging therapy, (2) over...
Barricaid offers surgeons an option to perform a limited nucleotomy in every patient, while closing the anulus in those patients that are left with a large anular defect following surgery.
Official Healthcare Professionals site for NORTHERA® (droxidopa), treatment for neurogenic orthostatic hypotension (nOH).
Oncozene Microspheres are precisely calibrated to enhance treatment options
LC Bead LUMI™ is a next-generation development of LC Bead® and first radiopaque embolic bead that allows you to treat consistently your patients with vision, precision and assurance.
Neurology Sen S, Androulakis XM et. al.
Nov 15th, 2018 - Migraine with visual aura is associated with cardioembolic stroke risk. The aim of this study was to test association between migraine with visual aura and atrial fibrillation (AF), in the Atherosclerosis Risk in Communities study. In the Atherosclerosis Risk in Communities study, a longitudinal, community-based cohort study, participants were interviewed for migraine history in 1993-1995 and w...
Neurology De Pablo-Fernandez E, Goldacre R et. al.
Jun 14th, 2018 - To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD). Linked English national Hospital Episode Statistics and mortality data (1999-2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk...
Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA; Malgo F, Hamdy NAT et. al.
Aug 26th, 2017 - We evaluated the value of VFA in the identification of vertebral fractures using a retrospective study and a meta-analysis. Performance of VFA was adequate in the meta-analysis although this was not demonstrated in our centre. We recommend checking the performance of VFA tools before exclusively relying on this tool. Vertebral fractures are traditionally diagnosed using conventional radiographs...