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Pipeline Flex Embolization Device

Access product information about the Pipeline Flex embolization device, which redefines treatment for large or giant wide-necked aneurysms by diverting flow away from the aneurysm neck and by reconstructing the parent artery and restoring its natural course.

Former U.S. President Carter Home for the Holidays After Surgery

Dec 2nd, 2019 - WASHINGTON (Reuters) - Former U.S. President Jimmy Carter was discharged from a hospital in Georgia on Wednesday after a successful surgery to relieve pressure on his brain, heading home one day before the Thanksgiving holiday. Carter, 95, had been hospitalized at Emory University in Atlanta in the latest episode in a string of recent health scares for the nation's oldest living former presiden...

Prevention of Secondary Fractures in Elderly With Hip or Vertebral Fracture Clinical Practice Guidelines (2019)

Nov 3rd, 2019 - The guidelines on preventing secondary fractures in persons aged 65 years or older with a hip or vertebral fracture were released on September 20, 2019, by the American Society for Bone and Mineral Research (ASBMR).[1] Fundamental Recommendations Communicate the following three simple messages to people aged 65 years or older with a hip or vertebral fracture (as well as to their family/caregive...

Rare Pediatric Diseases Special Report 2019

Oct 29th, 2019 - The Rare Pediatric Diseases Special Report is a supplement to Pediatric News that discusses advancements in the treatment of rare pediatric neuromuscular disorders like spinal muscular atrophy, Duchenne muscular dystrophy, and X-linked myotubular myopathy, as well as epileptic encephalopathies that occur in infancy and early childhood, such as West syndrome, Lennox-Gastaut syndrome, and Dravet.

Secondary Fracture Guidelines Urge Action to Stem Treatment Gap

Oct 7th, 2019 - ORLANDO, Florida — New consensus guidelines on the prevention of secondary fractures from a coalition of bone health experts, professional organizations, and patient advocacy groups provide comprehensive recommendations on the course of clinical care after hip or vertebral fracture in people aged 65 years and older, emphasizing treatment, communication, and multidisciplinary care interventions....

Pediatric Myelomeningocele Clinical Practice Guidelines (2019)

Oct 2nd, 2019 - The Congress of Neurological Surgeons (CNS) issued clinical practice guidelines for pediatric myelomeningocele in September 2019.[1] Prenatal myelomeningocele repair is recommended in fetuses who meet fetal and maternal Management of Myelomeningocele Study (MOMS)–specified criteria for prenatal surgery to decrease the likelihood of shunt-dependent hydrocephalus. The method of myelomeningocele c...

Cilantro leaf harbors a potent potassium channel-activating anticonvulsant
FASEB J; Manville RW, et al

Sep 30th, 2019 - Herbs have a long history of use as folk medicine anticonvulsants, yet the underlying mechanisms often remain unknown. Neuronal voltage-gated potassium channel subfamily Q (KCNQ) dysfunction can cause severe epileptic encephalopathies that are resistant to modern anticonvulsants. Here we report that cilantro (Coriandrum sativum), a widely used culinary herb that also exhibits antiepileptic and ...

Headache After Childbirth Epidural a Red Flag for Brain Bleed

Sep 24th, 2019 - Women who experience headaches following epidural anesthesia during childbirth have a greater risk of developing intracranial subdural hematoma, new research shows. Using a large database to study over 22 million deliveries, investigators found a 100-fold increase in subdural hematoma in women who experienced a headache following epidural, compared with their counterparts with subdural hematoma...

Postdural puncture headache linked to increased risk of subdural hematoma
Bianca Nogrady

Sep 16th, 2019 - Postdural puncture headache in women who have undergone neuraxial anesthesia in childbirth may be associated with a small but significant increase in the risk of being diagnosed with intracranial subdural hematoma, research findings suggest. A cohort study, published online in JAMA Neurology, looked at the incidence of intracranial subdural hematoma within 2 months of delivery in 22,130,815 wom.

Faulty Amino Acid Metabolism Linked to Rare Eye Disease

Sep 12th, 2019 - A defect in serine metabolism was found to be behind a rare macular disease, according to researchers reporting a new connection between central and peripheral neuropathies. Genetic mutations in SPTLC1 and SPTLC2, known to cause hereditary sensory and autonomic neuropathy type 1 (HSAN1), were also tied to macular telangiectasia type 2 from exome sequencing, according to a report by Martin Fried...

This Medical Mishap Kills 33,000 Americans a Year

Aug 18th, 2019 - It was a summer evening like most others for 13-year-old Drew Hughes. He was skateboarding with some friends when he fell, hitting his head. He was taken to the hospital by ambulance and when he arrived in the ER, he was awake, alert, and appeared to be fine. For Drew's safety, the doctor ordered a CT scan of his brain where evidence of a possible basilar skull fracture was identified. To be su...

This Medical Mishap Kills 33,000 Americans a Year

Aug 18th, 2019 - It was a summer evening like most others for 13-year-old Drew Hughes. He was skateboarding with some friends when he fell, hitting his head. He was taken to the hospital by ambulance and when he arrived in the ER, he was awake, alert, and appeared to be fine. For Drew's safety, the doctor ordered a CT scan of his brain where evidence of a possible basilar skull fracture was identified. To be su...

CSF Shunt Hazard With Close Proximity to Hearing Devices, FDA Warns

Jul 16th, 2019 - The US Food and Drug Administration (FDA) is warning healthcare providers about potential hazards from interactions between implanted programmable cerebrospinal fluid (CSF) shunts and hearing implants that contain magnets. CSF shunt systems are used to treat hydrocephalus. Adverse magnetic interactions can occur when these devices and hearing implants are in close proximity to one another. Such...

What is your diagnosis? - July 2019
Wai See Ma, MD, Hadi Moattar, MD, MBChB, PhD

Jun 28th, 2019 - The diagnosis von Hippel-Lindau disease The diagnosis is von Hippel-Lindau disease (VHL). Subsequent brain and renal magnetic resonance imaging showed features suggestive of a 5-mm right cerebellar hemangioblastoma and right renal cell carcinoma (RCC), respectively.

Ban 'Reprocessing' of Spinal Surgery Screws, Experts Say

May 19th, 2019 - In the wake of research that uncovered high levels of contamination in "sterile" implants, researchers are calling for the elimination of rewashing and resterilizing of pedicle screws in spinal fusion surgery. These researchers, including the president of the North American Spine Society, Jeffrey C. Wang, MD, and other leaders in the field, believe that intraoperatively guarded, presterilized, ...

Knowledge gaps about long-term osteoporosis drug therapy benefits, risks remain large
Jeff Craven

May 1st, 2019 - Long-term use of alendronate and zoledronic acid for more than 3 years reduces the rate of vertebral fracture in treatment-naive postmenopausal women with notable, yet rare, adverse events, but too little evidence exists to make determinations on the long-term benefit/risk profile of other bisphosphonates or other osteoporosis drugs besides raloxifene and oral hormone therapy, according to a re.

May 2019
Donna Bilu Martin, MD

Apr 17th, 2019 - Benign tumors consisting of glomus cells may be subdivided into two types: glomus tumors and glomuvenous malformations or glomangiomas. Glomus cells are modified smooth muscle cells that normally line the Sucquet-Hoyer canal, an arteriovenous fistula that is involved in temperature regulation in the digits.

A 60-year-old white male presented with a painful nodule on the right lateral thigh that had been present for years
Donna Bilu Martin, MD

Apr 17th, 2019 - Benign tumors consisting of glomus cells may be subdivided into two types: glomus tumors and glomuvenous malformations or glomangiomas. Glomus cells are modified smooth muscle cells that normally line the Sucquet-Hoyer canal, an arteriovenous fistula that is involved in temperature regulation in the digits.

LVAD-Related GI Bleeding: Another Reason to Take Heart Failure Drugs

Apr 8th, 2019 - Angiotensin II antagonists may help prevent GI bleeding among heart failure patients with continuous-flow left ventricular assist devices (LVADs), a retrospective study suggested. Taking ACE inhibitors or angiotensin receptor blockers (ARBs) at any point within the first 30 days following LVAD placement was associated with a reduced subsequent risk of major GI bleeds (15% vs 31%, adjusted HR 0....

What are the risks of long-term PPI use for GERD symptoms in patients > 65 years?
MDedge Family Medicine;

Apr 4th, 2019 - Hip and vertebral fracture riskis associated with PPIs A 2011 systematic review and meta-analysis investigated the risk of fracture in adult patients taking PPIs for any indication. 4 The analysis included 10 observational studies (4 cohort, 6 case-control) with a total of 223,210 fracture cases.

Doctors pray for sick as blackout batters Venezuelan hospitals

Mar 11th, 2019 - CARACAS (Reuters) - Maria Rodriguez’s daughter has spent a month in Caracas’s J.M. de los Rios children’s hospital with hydrocephalus, a buildup of spinal fluid in the brain, but staff there have faced an uphill battle treating the girl because of a nationwide power outage. Venezuelans, including doctors, hold banners that read "Solidarity" as they gather outside a public children hospital duri...

Spinal Fusions Ineffective for Fracture Pain, Says ASBMR

Jan 24th, 2019 - "Routine use of vertebral augmentation for pain relief after vertebral fracture is not supported by current data," a new report commissioned by the American Society for Bone and Mineral Research (ASBMR) concludes. The report, with lead author Peter R. Ebeling, MBBS, Monash University, Clayton, Australia, was published online January 24 in the Journal of Bone and Mineral Research. The most commo...

Hippocampal abnormalities seen in epilepsy subtypes may be congenital
Michele G. Sullivan

Dec 20th, 2018 - NEW ORLEANS – Abnormalities of hippocampal volume and morphology in children with temporal lobe or juvenile myoclonic epilepsy (JME) are also present in the brains of their unaffected siblings, although to a lesser extent, based on findings from two studies presented at the annual meeting of the American Epilepsy Society. While the studies suggest an imaging endophenotype associated with these.

Medtronic in $31 Million Settlement With DOJ Over Medical Devices

Dec 5th, 2018 - Two companies now owned by Medtronic have agreed to pay a total of $31 million to resolve US Department of Justice (DOJ) charges involving marketing violations and kickback schemes. Medical device maker ev3 has agreed to plead guilty to charges related to its neurovascular medical device Onyx Liquid Embolic System and pay $17.9 million, the DOJ said. The US Food and Drug Administration (FDA) ap...

Frontal Lobe Epilepsy Tied to Higher Seizure Risk in Pregnancy

Dec 5th, 2018 - NEW ORLEANS — Compared to women with other types of epilepsy, those with frontal lobe epilepsy have the highest risk of seizures worsening during pregnancy, new research shows. Investigators found that 53% of women with frontol lobe epilepsy experienced an increase in the frequency of seizures during pregnancy compared with before they became pregnant. "We showed for the first time that women w...

2018 Update on bone health

Dec 5th, 2018 - Age also is a key factor in fracture risk assessment Gourlay and colleagues more recently conducted a retrospective analysis of new occurrence of treatment-level fracture risk scores in postmenopausal women (50 years of age and older) before they received pharmacologic treatment and before they experienced a first hip or clinical vertebral fracture. In 54,280 postmenopausal women aged 50 to 64.

Frontal lobe epilepsy elevates seizure risk during pregnancy
Jake Remaly

Dec 3rd, 2018 - NEW ORLEANS – Seizure frequency increased during pregnancy for 53% of women with frontal lobe epilepsy, based on a study reported by Paula E. Voinescu, MD, PhD, at the annual meeting of the American Epilepsy Society.

Hydrocephalus: New Complication of Congenital Zika Syndrome

Nov 22nd, 2018 - Hydrocephalus may be a complication of congenital Zika syndrome, and the presenting signs and symptoms are challenging to recognize, a Brazilian group reports. Monitoring for hydrocephalus, including assessing the potential harbinger of cerebellar or brainstem hypoplasia, should be part of the standard care of patients with this condition, they conclude. "We present evidence that hydrocephalus ...

Experimental Skin Sensor May Warn of Hydrocephalus Shunt Failure

Nov 6th, 2018 - (Reuters Health) - A preliminary study suggests that a new skin sensor could help avoid life-threatening crises for the millions of people living with hydrocephalus, a condition that causes fluid to accumulate in the brain. When the disorder is diagnosed, a shunt is surgically inserted to drain excess fluid - but the 10-year failure rate for shunts is 98%, said the study's lead author Siddharth...

Experimental skin sensor may warn of brain fluid problems

Nov 5th, 2018 - (Reuters Health) - A preliminary study suggests that a new skin sensor could help avoid life-threatening crises for the millions of people living with hydrocephalus, a condition that causes fluid to accumulate in the brain. When the disorder is diagnosed, a tube, called a shunt, is surgically inserted to drain excess fluid. The problem is that shunts frequently clog or develop kinks and then fl...

Unique MRI Findings in Juvenile Myoclonic Epilepsy

Oct 24th, 2018 - The cortical regions of the brains of patients with juvenile myoclonic epilepsy (JME) are more likely to be disassociated from subcortical structures, according to a recent study that compared the MRI readings of JME patients to those of normal children. Investigators from the University of Wisconsin School of Medicine compared 21 children with JME to 22 healthy controls over a 2 year period.

The Rest of the Story on Vitamin B for Stroke Prevention

Oct 17th, 2018 - It is clear that high levels of total homocysteine (tHcy) are a strong, graded risk factor for vascular disease. This is particularly true for cardioembolic stroke; high levels of tHcy quadruple the risk of stroke in atrial fibrillation. Vitamin therapy with folic acid, B6, and B12 can lower levels of tHcy, so it was logical to think that they should reduce the risk of cardiovascular events. No...

The Autopsy of Dr Death: An Interview With Laura Beil

Oct 9th, 2018 - Laura Beil is a health and science writer who won the 2018 Victor Cohn Prize for Excellence in Medical Science Reporting from the Council for the Advancement of Science Writing. Laura Beil One of her latest projects, Dr. Death, is an incredibly popular six-part podcast from Wondery that explores the case of Christopher Duntsch. The neurosurgeon is alleged to have injured 33 patients and was con...

New secondary fracture–prevention recommendations carry simple messages
Karen Blum

Oct 8th, 2018 - Ensuring that older adults who have experienced a hip or vertebral fracture understand they likely have osteoporosis, and offering prompt drug treatment for the condition, are among five fundamental recommendations put together by a coalition of U. S.

Why I Dance with My Patients

Oct 4th, 2018 - View this post on Instagram One of my little buddies waited until I came on morning rounds in order to show off his skills. He is a warrior ???????. ?? ?? ?? ?? #neurology #brain #cancersucks #spinabifida #cerebralpalsy #physicianassistant #neurosurgery #nurse #doctor #cancer #chiari #hydrocephalus #patientadvocate #lipsync #patient #instagood #pacu #dance #MrNeuro #nicu #aapa #picu #bowties #b...

Why I Dance with My Patients

Oct 4th, 2018 - View this post on Instagram One of my little buddies waited until I came on morning rounds in order to show off his skills. He is a warrior ???????. ?? ?? ?? ?? #neurology #brain #cancersucks #spinabifida #cerebralpalsy #physicianassistant #neurosurgery #nurse #doctor #cancer #chiari #hydrocephalus #patientadvocate #lipsync #patient #instagood #pacu #dance #MrNeuro #nicu #aapa #picu #bowties #b...

Prevention of Cardioembolic Stroke in Obese Patients With Nonvalvular Atrial Fibrillation

Sep 30th, 2018 - This article is republished with permission from the ACC. For more, see www.ACC.org. Ms. X is a 70-year-old female with new onset non-valvular atrial fibrillation. She has a past medical history of hypertension, diabetes, hyperlipidemia and morbid obesity. BMI 43.7 kg/m2, 123 kg, 66 inches. CrCl 45 mL/min. There are no pertinent drug interactions.

Consider Atrial Fibrillation in Patients With Stroke and Obstructive Sleep Apnea

Sep 27th, 2018 - A Single-Center Study Researchers at Mayo Clinic compared strokes in patients with and without OSA. They examined data from patients who had their first ischemic stroke within one year after undergoing polysomnography.

Brain Injury May Raise Risk of Suicide

Aug 14th, 2018 - Action Points Traumatic brain injury (TBI) may be linked to a higher risk of suicide. Note that the association with suicide is highest in the first couple of years after the TBI incident; suicide risk is more than three-fold elevated the first 6 months after a TBI in the study. Traumatic brain injury (TBI) was linked to a higher risk of suicide in a nationwide retrospective population-based st...

Can a Statin Treat Chronic Subdural Hematoma?

Jul 29th, 2018 - Action Points Chinese patients with chronic subdural hematoma (CSDH) taking atorvastatin for 8 weeks had a larger decrease in hematoma volume and were twice as likely to show improved neurologic function as patients taking placebo. Note that with the continuous increase in life expectancy and the therapeutic or prophylactic use of anticoagulation and antiplatelet medications, the incidence of C...

Getting Ahead of the Pain
Nandan R. Hichkad, PA-C, MMSc

Jun 12th, 2018 - ANSWER The image reveals a hypodense extra-axial fluid collection in the right frontoparietal region, measuring 8 to 10 mm in diameter. There is some mass effect and evidence of right-to-left shift.

Routine CT Not Warranted After Chronic Subdural Hematoma Surgery

May 23rd, 2018 - GOTHENBURG, Sweden — Not only is routine computed tomography (CT) to check for recurrence after evacuation surgery for chronic subdural hematoma unnecessary, but patients scanned on an as-needed basis actually experience better outcomes, a new prospective, randomized study suggests. "We found no benefit of routine follow-up CT scans in terms of good clinical outcome at 6 months. On the contrary...

All-Terrain, No Control
Nandan R. Hichkad, PA-C, MMSc

May 16th, 2018 - ANSWER The image shows a large, convex hyperdensity within the left parietal region. This is a textbook image of an acute epidural hematoma.

FDA places tazemetostat trials on partial hold
HT Staff

Apr 25th, 2018 - The US Food and Drug Administration (FDA) has placed a partial hold on clinical trials of tazemetostat, an EZH2 inhibitor being developed to treat solid tumors and lymphomas. The hold has halted enrollment in US-based trials of tazemetostat, but study subjects who have not experienced disease progression may continue to receive the drug.

Newborns Hurt in Wisconsin NICU (CBS News)

Mar 9th, 2018 - Unexplained injuries to five newborns could cost a Madison, Wis., hospital its Medicare payments contract, CBS News reports. Investigators from the Centers for Medicare and Medicaid Services found that patients in the neonatal intensive care unit (NICU) of the UnityPoint Health-Meriter hospital were in "immediate jeopardy" after the hospital failed to properly investigate the first of the five ...

Simple Walking Test Helps Diagnose Treatable Cause of Dementia

Feb 26th, 2018 - A simple walking test may help identify one cause of dementia that may be reversible but is often misdiagnosed, a new study suggests. Idiopathic normal-pressure hydrocephalus (iNPH) is estimated to affect about 2.7 million people in the United States and Europe. It is caused by excess fluid in the brain and can often be reversed with the insertion of a ventriculoperitoneal shunt. However, it is...

Thumbs Down on Calcium and Vitamin D to Prevent Hip Fracture

Jan 13th, 2018 - A recent JAMA meta-analysis of 33 clinical trials and 51,145 participants showed that calcium, vitamin D, or both affords no decreased risk of hip fractures compared with placebo or no treatment. The authors performed a systematic literature review of data from published randomized trials, performed from July 16, 2012, to July 16, 2017. The primary outcome of interest was hip fracture and secon...

Review: Common gastrointestinal conditions in people living with HIV/AIDS
Lucas Franki

Jan 10th, 2018 - The two most common gastrointestinal conditions reported by people living with HIV/AIDS are diarrhea and nausea, according to Vincent Hall, PhD. Diarrhea has been reported in up to 60% of people living with HIV/AIDS, and is generally classified as being infectious or noninfectious.