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About 29,490 results
Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women W...
https://doi.org/10.1001/jama.2016.11136
JAMA Miller PD, Hattersley G et. al.

Aug 17th, 2016 - Additional therapies are needed for prevention of osteoporotic fractures. Abaloparatide is a selective activator of the parathyroid hormone type 1 receptor. To determine the efficacy and safety of abaloparatide, 80 μg, vs placebo for prevention of new vertebral fracture in postmenopausal women at risk of osteoporotic fracture. The Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) w...

Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack.
https://doi.org/10.1056/NEJMoa1603060
The New England Journal of Medicine; Johnston SC, Amarenco P et. al.

May 10th, 2016 - Ticagrelor may be a more effective antiplatelet therapy than aspirin for the prevention of recurrent stroke and cardiovascular events in patients with acute cerebral ischemia. We conducted an international double-blind, controlled trial in 674 centers in 33 countries, in which 13,199 patients with a nonsevere ischemic stroke or high-risk transient ischemic attack who had not received intravenou...

Vascular factors in suspected normal pressure hydrocephalus: A population-based study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762415
Neurology Jaraj D, Agerskov S et. al.

Jan 16th, 2016 - We examined clinical and imaging findings of suspected idiopathic normal pressure hydrocephalus (iNPH) in relation to vascular risk factors and white matter lesions (WMLs), using a nested case-control design in a representative, population-based sample. From a population-based sample, 1,235 persons aged 70 years or older were examined with CT of the brain between 1986 and 2000. We identified 55...

Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2)...
https://doi.org/10.1016/S1474-4422(15)00046-0
The Lancet. Neurology; Kazui H, Miyajima M et. al.

May 2nd, 2015 - Lumboperitoneal shunt surgery has the potential to alleviate symptoms of normal pressure hydrocephalus but the benefits of such surgery have not been tested in a randomised trial. The aim of this trial was to determine the safety and efficacy of the lumboperitoneal shunt surgery for this disorder. For the open-label randomised SINPHONI-2 trial, eligible participants (60-85 years of age) with id...

The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356153
Lancet (London, England); Molyneux AJ, Birks J et. al.

Dec 3rd, 2014 - Previous analyses of the International Subarachnoid Aneurysm Trial (ISAT) cohort have reported on the risks of recurrent subarachnoid haemorrhage and death or dependency for a minimum of 5 years and up to a maximum of 14 years after treatment of a ruptured intracranial aneurysm with either neurosurgical clipping or endovascular coiling. At 1 year there was a 7% absolute and a 24% relative risk ...

Actionable diagnosis of neuroleptospirosis by next-generation sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134948
The New England Journal of Medicine; Wilson MR, Naccache SN et. al.

Jun 4th, 2014 - A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 se...

Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentr...
https://doi.org/10.1016/S0140-6736(19)31603-4
Lancet (London, England); Mallucci CL, Jenkinson MD et. al.

Sep 16th, 2019 - Insertion of a ventriculoperitoneal shunt for hydrocephalus is one of the commonest neurosurgical procedures worldwide. Infection of the implanted shunt affects up to 15% of these patients, resulting in prolonged hospital treatment, multiple surgeries, and reduced cognition and quality of life. Our aim was to determine the clinical and cost-effectiveness of antibiotic (rifampicin and clindamyci...

Safety and Efficacy of Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724157
JAMA Neurology; Ferro JM, Coutinho JM et. al.

Sep 3rd, 2019 - Patients with cerebral venous thrombosis (CVT) are at risk of recurrent venous thrombotic events (VTEs). Non-vitamin K oral anticoagulants have not been evaluated in randomized controlled trials in CVT. To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT. RE-SPECT CVT is an explorator...

Anticoagulation After Stroke in Patients With Atrial Fibrillation.
https://doi.org/10.1161/STROKEAHA.118.022856
Stroke Altavilla R, Caso V et. al.

Jun 21st, 2019 - Background and Purpose- Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of a higher incidence of intracerebral bleeding. However, this practice is common in clinical settings. This observational study aimed to compare (1) the clinical profiles of patients receiving and not receiving bridging therapy, (2) over...

Migraine with visual aura is a risk factor for incident atrial fibrillation: A cohort s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329332
Neurology Sen S, Androulakis XM et. al.

Nov 15th, 2018 - Migraine with visual aura is associated with cardioembolic stroke risk. The aim of this study was to test association between migraine with visual aura and atrial fibrillation (AF), in the Atherosclerosis Risk in Communities study. In the Atherosclerosis Risk in Communities study, a longitudinal, community-based cohort study, participants were interviewed for migraine history in 1993-1995 and w...

Association between diabetes and subsequent Parkinson disease: A record-linkage cohort ...
https://doi.org/10.1212/WNL.0000000000005771
Neurology De Pablo-Fernandez E, Goldacre R et. al.

Jun 14th, 2018 - To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD). Linked English national Hospital Episode Statistics and mortality data (1999-2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk...

Value and potential limitations of vertebral fracture assessment (VFA) compared to conv...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624976
Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA; Malgo F, Hamdy NAT et. al.

Aug 26th, 2017 - We evaluated the value of VFA in the identification of vertebral fractures using a retrospective study and a meta-analysis. Performance of VFA was adequate in the meta-analysis although this was not demonstrated in our centre. We recommend checking the performance of VFA tools before exclusively relying on this tool. Vertebral fractures are traditionally diagnosed using conventional radiographs...

Small Cerebral Aneurysms: Can We Identify Patients at Risk for Rupture?
https://doi.org/10.7326/M17-1215
Annals of Internal Medicine; Starke RM

Jun 6th, 2017 - Small Cerebral Aneurysms: Can We Identify Patients at Risk for Rupture?|2017|Starke RM,|complications,complications,

Extracranial Carotid Disease and Effect of Intra-arterial Treatment in Patients With Pr...
https://doi.org/10.7326/M16-1536
Annals of Internal Medicine; Berkhemer OA, Borst J et. al.

May 22nd, 2017 - The presence of extracranial carotid disease (ECD) is associated with less favorable clinical outcomes in patients with acute ischemic stroke caused by intracranial proximal occlusion. Acute intra-arterial treatment (IAT) in the setting of extracranial and intracranial lesions is considered challenging, and whether it yields improved outcomes remains uncertain. To examine whether the presence o...

Outcomes after intracerebral hemorrhage from arteriovenous malformations.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444313
Neurology Murthy SB, Merkler AE et. al.

Apr 20th, 2017 - To compare outcomes after intracerebral hemorrhage (ICH) from cerebral arteriovenous malformation (AVM) rupture and other causes of ICH. We performed a retrospective population-based study using data from the Nationwide Inpatient Sample. We used standard diagnosis codes to identify ICH cases from 2002 to 2011. Our predictor variable was cerebral AVM. Our primary outcomes were inpatient mortalit...

Association of Antithrombotic Drug Use With Subdural Hematoma Risk.
https://doi.org/10.1001/jama.2017.0639
JAMA Gaist D, García Rodríguez LA et. al.

Feb 28th, 2017 - Incidence of subdural hematoma has been reported to be increasing. To what extent this is related to increasing use of antithrombotic drugs is unknown. To estimate the association between use of antithrombotic drugs and subdural hematoma risk and determine trends in subdural hematoma incidence and antithrombotic drug use in the general population. Case-control study of 10 010 patients aged 20 t...

A QI Initiative to Reduce Hospitalization for Children With Isolated Skull Fractures.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894255
Pediatrics Lyons TW, Stack AM et. al.

May 31st, 2016 - Although children with isolated skull fractures rarely require acute interventions, most are hospitalized. Our aim was to safely decrease the hospitalization rate for children with isolated skull fractures. We designed and executed this multifaceted quality improvement (QI) initiative between January 2008 and July 2015 to reduce hospitalization rates for children ≤21 years old with isolated sku...

Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, pha...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115605
Neurology Kaufmann H, Freeman R et. al.

Jun 19th, 2014 - To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa dose optimization (100-600 mg 3 times daily), followed, in responders, by 7-day washout and then...

Outcome after conservative management or intervention for unruptured brain arteriovenou...
https://doi.org/10.1001/jama.2014.3200
JAMA Al-Shahi Salman R, White PM et. al.

Apr 23rd, 2014 - Whether conservative management is superior to interventional treatment for unruptured brain arteriovenous malformations (bAVMs) is uncertain because of the shortage of long-term comparative data. To compare the long-term outcomes of conservative management vs intervention for unruptured bAVM. Population-based inception cohort study of 204 residents of Scotland aged 16 years or older who were f...

Management of hydrocephalus in patients with leptomeningeal metastases: an ethical appr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182391
Journal of Neuro-oncology; Lamba N, Fick T et. al.

Jul 19th, 2018 - Leptomeningeal metastases (LM) are a rare, but often debilitating complication of advanced cancer that can severely impact a patient's quality-of-life. LM can result in hydrocephalus (HC) and lead to a range of neurologic sequelae, including weakness, headaches, and altered mental status. Given that patients with LM generally have quite poor prognoses, the decision of how to manage this HC rema...