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About 31,510 results
Assessment of peripheral blood cell inflammatory markers in patients with chronic subdu...
https://doi.org/10.1016/j.clineuro.2020.105738
Clinical Neurology and Neurosurgery; Zhang Y, Yang Y et. al.

Feb 22nd, 2020 - We aimed to study the role of peripheral blood cell inflammatory markers in patients with chronic subdural hematoma (CSDH). We enrolled 466 patients with CSDH and 150 healthy controls and retrospectively analyzed peripheral blood cell inflammatory markers, including neutrophils, platelets, lymphocytes, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). Subsequently, we perf...

Comprehensive analysis of dysregulated exosomal long non-coding RNA networks associated...
https://doi.org/10.1016/j.gene.2020.144482
Gene Li X, Gui Z et. al.

Feb 22nd, 2020 - Arteriovenous malformations (AVMs) are congenital vascular lesions with a high tendency for aggravation and recurrence after treatment, and their genesis remains enigmatic. In this study, we investigated exosomal long non-coding RNA (lncRNA) and mRNA expression and constructed a competitive endogenous RNA regulatory network in AVMs. Ethics approval was provided, and informed written consent was...

Does pre-resection endoscopic third ventriculostomy prevent the need for post-resection...
https://doi.org/10.3171/2019.12.PEDS19539
Journal of Neurosurgery. Pediatrics; Srinivasan HL, Foster MT et. al.

Feb 20th, 2020 - Children with posterior fossa tumors (PFTs) may present with hydrocephalus. Persistent (or new) hydrocephalus is common after PFT resection. Endoscopic third ventriculostomy (ETV) is sometimes performed prior to resection to 1) temporize hydrocephalus prior to resection and 2) prophylactically treat post-resection hydrocephalus. The objective of this study was to establish, in a historical coho...

Cerebrospinal fluid area and syringogenesis in Chiari malformation type I.
https://doi.org/10.3171/2019.11.JNS191439
Journal of Neurosurgery; Taylor DG, Chatrath A et. al.

Feb 20th, 2020 - Syringogenesis in Chiari malformation type I (CM-I) is thought to occur secondary to impaction of the cerebellar tonsils within the foramen magnum (FM). However, the correlation between the CSF area and syringogenesis has yet to be elucidated. The authors sought to determine whether the diminution in subarachnoid space is associated with syringogenesis. Further, the authors sought to determine ...

Programmable valve breakage in shunt systems of children with posthemorrhagic hydroceph...
https://doi.org/10.1007/s00381-020-04541-6
Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery; Schwarm FP, Nagl J et. al.

Feb 19th, 2020 - We report five rare cases of programmable valve breakage (Codman Hakim-Medos valve) in shunt systems of children with posthemorrhagic hydrocephalus. Only four similar studies have been published in the current literature. Between 2013 and 2018, five children with posthemorrhagic hydrocephalus were admitted to the pediatric department. All patients had a history of slight blows to the head in a ...

A case of multiple Vertebrobasilar artery fenestration misdiagnosed as vertebral artery...
https://doi.org/10.1186/s12883-020-01642-2
BMC Neurology; Wang F, Wang X et. al.

Feb 19th, 2020 - Fenestration of vertebra-basilar artery is an uncommon congenital vascular anomaly, which is identified by incidental findings on imaging in patients presented without related symptoms or in patients with intracerebral hemorrhage secondary to concomitant artery aneurysm or arteriovenous malformations. Yet, cases of fenestration being misdiagnosed as cerebral artery dissection have never been re...

The relationship between glycaemic variability and cardiovascular autonomic dysfunction...
https://doi.org/10.1002/dmrr.3301
Diabetes/metabolism Research and Reviews; Helleputte S, De Backer T et. al.

Feb 18th, 2020 - Rigorous glycaemic control - reflected by low HbA1c goals - is of utmost importance in the prevention and management of complications in patients with type 1 diabetes mellitus (T1DM). However, previous studies suggested that short-term glycaemic variability (GV) is important to consider as well, as excessive glucose fluctuations may have an additional impact on the development of diabetic compl...

The risk of intracranial infection in adults with hydrocephalus after ventriculoperiton...
https://doi.org/10.1111/iwj.13331
International Wound Journal REFERENCES; Yang YN, Zhang J et. al.

Feb 18th, 2020 - Infection remains the most significant complication of ventriculoperitoneal shunt (VPS) surgery. The objective of this study was to investigate intracranial infections complicating VPS surgery in adults with hydrocephalus. Patients who underwent VPS surgery for hydrocephalus between 2000 and 2016 were included. Clinical data and follow-up evaluations were examined and analysed retrospectively. ...

Is scan-negative cauda equina syndrome a functional neurological disorder? A pilot study.
https://doi.org/10.1111/ene.14182
European Journal of Neurology; Gibson LL, Harborow L et. al.

Feb 18th, 2020 - Cauda equina syndrome (CES) is a neurosurgical emergency which warrants a lumbar MRI. Many patients with suggestive symptoms of CES have no radiological correlate. A functional (non-organic) aetiology has been proposed in some, but currently little is known about this patient group and their clinical outcomes. At a tertiary referral centre, 155 adult patients underwent urgent lumbar MRI for sus...

Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma ther...
https://doi.org/10.1007/s11060-020-03418-7
Journal of Neuro-oncology; Michmerhuizen NL, Owen JH et. al.

Feb 18th, 2020 - Chordomas are rare and serious tumors with few effective treatments outside of aggressive surgery and radiation. Targeted therapies may present a more effective option for a subset of patients with lesions possessing certain genetic biomarkers. A small molecule inhibitor library was tested in patient-derived UM-Chor1 cells to identify targeted therapies with potential efficacy. Targeted exome s...

Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar ...
https://doi.org/10.1186/s13018-020-01588-8
Journal of Orthopaedic Surgery and Research; Guan Y, Wang S et. al.

Feb 17th, 2020 - To investigate the association between interleukin-6 (IL-6) (rs1800795, rs1800796, rs1800797, rs13306435, rs2069849) and interleukin-10 (IL-10) (rs1800871, rs1800896) gene polymorphisms, expression levels, and lumbar disc disease (LDD). We conducted a literature research on PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure (CNKI) until February 28, 20...

Fifteen-minute consultation: Management of the infant born to a mother with toxoplasmos...
https://doi.org/10.1136/archdischild-2018-316603
Archives of Disease in Childhood. Education and Practice Edition; Saso A, Bamford A et. al.

Feb 17th, 2020 - Congenital toxoplasmosis occurs following transplacental transfer of Toxoplasma gondii Irrespective of symptom status at birth, infants with congenital infection may develop serious long-term sequelae, including learning disability, seizures, hydrocephalus, motor and hearing deficits, chorioretinitis and retinal scarring with impaired vision. Timely diagnosis facilitates early initiation of the...

Levetiracetam - levetiracetam tablet-PD-Rx Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c2177034-e164-453c-be02-1cf91ce27a07

Feb 17th, 2020 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older ( 1.1) Levetiracetam is indicated for adjunctive therapy in the treatment of: Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy ( 1.2) Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epileps...

Imaging detection of cerebral artery fenestrations and their clinical correlation with ...
https://doi.org/10.1016/j.clinimag.2020.01.012
Clinical Imaging; Wu X, Chen X et. al.

Feb 17th, 2020 - Cerebral artery fenestrations detected incidentally during computed tomographic angiography (CTA) or magnetic resonance angiography (MRA) are reported to be associated with aneurysmal dilatation, which may cause cerebrovascular diseases, arteriovenous malformations, or, rarely, ischemic symptoms. We retrospectively analyzed CTA and MRA of patients with cerebral artery fenestration examined betw...

Chemical meningitis in children as a risk factor following craniopharyngioma resection ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023736
BMC Neurology; Chrościńska-Krawczyk M, Zienkiewicz E et. al.

Feb 17th, 2020 - Craniopharyngiomas are defined by the WHO as "benign" tumours, but their location and surgical treatment may be associated with major complications, one being chemical meningitis. Although rare, especially in children, it should be taken into account when worrying symptoms appear after surgery. The aim of this study is to present the case of chemical meningitis in a 7-year-old girl. She was adm...

Iodine-123-iomazenil SPECT Revealed Recovery of Neuronal Viability in Association with ...
https://doi.org/10.1016/j.wneu.2020.02.067
World Neurosurgery; Horiuchi R, Yoshioka H et. al.

Feb 17th, 2020 - Iodine-123-iomazenil SPECT Revealed Recovery of Neuronal Viability in Association with Improvement in Symptoms Following Treatment for Obstructive Hydrocephalus Due to A Giant Posterior Cerebral Artery Aneurysm: Case Report.|2020|Horiuchi R,Yoshioka H,Kanemaru K,Hashimoto K,Yagi T,|

Corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial ...
https://doi.org/10.1186/s12987-020-0167-0
Fluids and Barriers of the CNS; Sirkka J, Säisänen L et. al.

Feb 16th, 2020 - Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease with an unknown etiology. Disturbed corticospinal inhibition of the motor cortex has been reported in iNPH and can be evaluated in a noninvasive and painless manner using navigated transcranial magnetic stimulation (nTMS). This is the first study to characterize the immediate impact of cerebrospinal fluid (CSF) drain...

Stereotactic Radiosurgery for Spetzler-Martin Grade I and II Arteriovenous Malformation...
https://doi.org/10.1093/neuros/nyaa004
Neurosurgery Graffeo CS, Sahgal A et. al.

Feb 16th, 2020 - No guidelines have been published regarding stereotactic radiosurgery (SRS) in the management of Spetzler-Martin grade I and II arteriovenous malformations (AVMs). To establish SRS practice guidelines for grade I-II AVMs on the basis of a systematic literature review. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant search of Medline, Embase, and Scopus, 198...

Efficacy analysis of percutaneous pedicle screw fixation combined with percutaneous ver...
https://doi.org/10.1186/s13018-020-1583-1
Journal of Orthopaedic Surgery and Research; Li Z, Wang Y et. al.

Feb 16th, 2020 - To investigate the clinical effect of percutaneous pedicle screw fixation (PPSF) combined with percutaneous vertebroplasty (PVP) in the treatment of osteoporotic compression vertebral fracture (OVCF) of the thoracolumbar vertebra with kyphosis. One hundred sixty-six patients before June 2017 were retrospectively analyzed, and patients were divided into PPSF + PVP group A and PVP group B. Operat...

The paradox of cancer genes in non-malignant conditions: implications for precision med...
https://doi.org/10.1186/s13073-020-0714-y
Genome Medicine; Adashek JJ, Kato S et. al.

Feb 16th, 2020 - Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures. Intriguingly, rapidly emerging data indicate that altered genes representing oncogenic drivers can also be found in sporadic non-malignant conditions, some of which have negligible and/or low potential for transformation...