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About 4,598 results

ALLMedicine™ Acromegaly Center

Research & Reviews  1,494 results

Safety and Efficacy of Pegvisomant in Children With Growth Hormone Excess
https://clinicaltrials.gov/ct2/show/NCT03882034

Feb 3rd, 2023 - Study Description: Growth hormone excess is a rare and potentially lethal condition associated with hypersecretion of growth hormone (GH), usually by a pituitary tumor or hyperplasia. When it occurs prior to the complete fusion of growth plates, i...

Polycystic ovary syndrome preceding the diagnosis of acromegaly: a retrospective study ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890864
Reproductive Biology and Endocrinology : RB&E; Khiyami AM, Jokar TO et. al.

Feb 2nd, 2023 - Acromegaly is a disease of growth hormone excess that results in enlargement of extremities, abnormal glucose and lipid metabolism, and gonadal disruption. Manifestations of the disease are insidious and typically lead to a diagnostic delay of 7-1...

A Study to Assess the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Debio 4126 in Participants With Acromegaly or Functioning Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs)
https://clinicaltrials.gov/ct2/show/NCT05364944

Jan 30th, 2023 - This is an open-label, single treatment arm, multicenter study to assess the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of Debio 4126 in the treatment of participants with Acromegaly or Functioning Gastroenteropancreati...

Epidemiology, course, and outcomes of Sars-CoV-2 infection in patients with acromegaly ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884127
Journal of Endocrinological Investigation; Ragonese M, Giuffrida G et. al.

Jan 29th, 2023 - Acromegaly (AC) and Cushing's disease (CD) increase morbidity and mortality due to cardio-metabolic alterations, and overall cause frailty in the affected patients, potentially making them more susceptible to infective diseases. However, up to now...

Genetic Studies of Insulin and Diabetes
https://clinicaltrials.gov/ct2/show/NCT00001987

Jan 27th, 2023 - Study Description: Insulin is the key hormone responsible for regulating the level of glucose in plasma. In several disease states (e.g., obesity, type 2 diabetes, and acromegaly), the target cells are resistant to insulin action. Insulin resistan...

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Guidelines  5 results

Italian Society for the Study of Diabetes (SID)/Italian Endocrinological Society (SIE) ...
https://doi.org/10.1016/j.numecd.2016.02.001
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD; Baroni MG, Giorgino F et. al.

Feb 26th, 2016 - Hyperglycemia is a common feature associated with states of increased growth hormone secretion and glucocorticoid levels. The purpose of these guidelines is to assist clinicians and other health care providers to take evidence-based therapeutic de...

Expert consensus document: A consensus on the medical treatment of acromegaly.
https://doi.org/10.1038/nrendo.2014.21
Nature Reviews. Endocrinology; Giustina A, Chanson P et. al.

Feb 26th, 2014 - In March 2013, the Acromegaly Consensus Group met to revise and update guidelines for the medical treatment of acromegaly. The meeting comprised experts skilled in the medical management of acromegaly. The group considered treatment goals covering...

American Association of Clinical Endocrinologists medical guidelines for clinical pract...
https://www.ncbi.nlm.nih.gov/pubmed/21846616
Endocrine Practice : Official Journal of the American Col... Katznelson L, Atkinson JL et. al.

Aug 24th, 2011 - American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of acromegaly--2011 update.|2011|Katznelson L,Atkinson JL,Cook DM,Ezzat SZ,Hamrahian AH,|diagnosis,therapy,standards,trends,...

AME Position Statement on clinical management of acromegaly.
https://www.ncbi.nlm.nih.gov/pubmed/19923883
Journal of Endocrinological Investigation; Cozzi R, Baldelli R et. al.

Jan 23rd, 2010 - AME Position Statement on clinical management of acromegaly.|2010|Cozzi R,Baldelli R,Colao A,Lasio G,Zini M,|diagnosis,economics,epidemiology,therapy,

Guidelines for acromegaly management: an update.
https://doi.org/10.1210/jc.2008-2421
The Journal of Clinical Endocrinology and Metabolism; Melmed S, Colao A et. al.

Feb 12th, 2009 - The Acromegaly Consensus Group reconvened in November 2007 to update guidelines for acromegaly management. The meeting participants comprised 68 pituitary specialists, including neurosurgeons and endocrinologists with extensive experience treating...

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Drugs  30 results see all →

Clinicaltrials.gov  177 results

Safety and Efficacy of Pegvisomant in Children With Growth Hormone Excess
https://clinicaltrials.gov/ct2/show/NCT03882034

Feb 3rd, 2023 - Study Description: Growth hormone excess is a rare and potentially lethal condition associated with hypersecretion of growth hormone (GH), usually by a pituitary tumor or hyperplasia. When it occurs prior to the complete fusion of growth plates, i...

A Study to Assess the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Debio 4126 in Participants With Acromegaly or Functioning Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs)
https://clinicaltrials.gov/ct2/show/NCT05364944

Jan 30th, 2023 - This is an open-label, single treatment arm, multicenter study to assess the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of Debio 4126 in the treatment of participants with Acromegaly or Functioning Gastroenteropancreati...

Genetic Studies of Insulin and Diabetes
https://clinicaltrials.gov/ct2/show/NCT00001987

Jan 27th, 2023 - Study Description: Insulin is the key hormone responsible for regulating the level of glucose in plasma. In several disease states (e.g., obesity, type 2 diabetes, and acromegaly), the target cells are resistant to insulin action. Insulin resistan...

A Trial to Assess the Long-term Safety of Octreotide Subcutaneous Depot in Patients With Acromegaly
https://clinicaltrials.gov/ct2/show/NCT04125836

Jan 20th, 2023 - The purpose of this trial is to assess the long-term safety of CAM2029 in patients with acromegaly. Patients will be administered CAM2029 subcutaneously once monthly during 12 months. Patients fulfilling trial NCT04076462 will be offered to contin...

Effects of GH and Lirglutide on AgRP
https://clinicaltrials.gov/ct2/show/NCT05681299

Jan 12th, 2023 - Rationale: GH and IGF-1 are vital to growth and metabolism across the human lifespan. In disorders of GH/IGF-1 excess and deficiency and the many other disease processes that perturb these hormones, significant growth and metabolic abnormalities c...

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News  121 results

Super-Ager Brains; NIA Issues Lecanemab Statement; New NFL Concussion Protocol?
https://www.medpagetoday.com/neurology/generalneurology/101053

Oct 4th, 2022 - In super-agers -- people 80 and older with exceptional episodic memory -- entorhinal cortex neurons were significantly larger compared with cognitively average peers and individuals 20-30 years younger. (Journal of Neuroscience) A multimodal pain ...

When to Treat Low Testosterone in Diabetes and Obesity
https://www.medscape.com/viewarticle/977284

Jul 15th, 2022 - Men with type 2 diabetes are at higher risk for testosterone deficiency. And in turn, hypogonadism is commonly associated with metabolic syndrome or type 2 diabetes. However, this does not imply a specific need for action, as Stephan Petersenn, MD...

FDA Halts Diabetes Cell Tx Trial; Europe's Obesity Epidemic; Acromegaly Fractures
https://www.medpagetoday.com/endocrinology/generalendocrinology/98544

May 4th, 2022 - The FDA placed a clinical hold on Vertex's investigational diabetes cell therapy VX-880, saying the company didn't have enough evidence to support a treatment dose increase. (Fierce Biotech) A study from England found that surgeons who performed f...

Practice Guidelines Highlights From the Past Year
https://www.medscape.com/viewarticle/969871

Mar 8th, 2022 - Dr Douglas S. Paauw A 64-year-old woman is evaluated for fever, diarrhea, and abdominal pain. She was diagnosed with Clostridioides difficile 2 months ago and completed a 10-day course of vancomycin. Her stool toxin test is positive for Clostridio...

Practice guidelines highlights from past year
https://www.mdedge.com/internalmedicine/article/252401/infectious-diseases/practice-guidelines-highlights-past-year
Douglas S. Paauw, MD

Mar 3rd, 2022 - A 64-year-old woman is evaluated for fever, diarrhea, and abdominal pain. She was diagnosed with Clostridioides difficile 2 months ago and completed a 10-day course of vancomycin.

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Patient Education  12 results see all →