ALLMedicine™ Gout Center

Mar 23rd, 2023 - Background Circumcision of males involves removing the fold of skin that normally covers the glans penis. Although no consensus exists among scholars regarding the origins of circumcision, some have suggested that this procedure likely originated ...

Mar 22nd, 2023 - Age-related diseases are frequently linked to pathological immune dysfunction, including excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human genetic data have revealed that somatic mutations and mosaic chromosomal...

Mar 22nd, 2023 - In patients with gout there is a lack of longitudinal studies on the course of work productivity. We explored longitudinal changes in and predictors of work productivity over 2 years. Patients in the NOR-Gout observational study with a recent gout...

Mar 21st, 2023 - Clonal hematopoiesis (CH) refers to age-associated expansion of somatic variants in hematopoietic stem and progenitor cells (HSPC). CH of indeterminate potential (CHIP) is operationally defined as pathogenic variants in HSPCs at a variant allele f...

Mar 21st, 2023 - Colchicine is an FDA-approved medicine that has been used for many years to prevent and treat gout flares as well as familial mediterranean fever. It is also used off-label to treat pericarditis, calcium pyrophosphate illness, and Behçet's syndrom...

Aug 2nd, 2022 - Question Among patients with gout, is there a transient increase in the risk of cardiovascular events after gout flares?

Dec 22nd, 2021 - Gout is the most prevalent inflammatory arthritis in the Asia-Pacific region and worldwide. This clinical practice guideline (CPG) aims to provide recommendations based on systematically obtained evidence and values and preferences tailored to the...

May 12th, 2020 - To provide guidance for the management of gout, including indications for and optimal use of urate-lowering therapy (ULT), treatment of gout flares, and lifestyle and other medication recommendations. Fifty-seven population, intervention, comparat...

May 12th, 2020 - To provide guidance for the management of gout, including indications for and optimal use of urate-lowering therapy (ULT), treatment of gout flares, and lifestyle and other medication recommendations. Fifty-seven population, intervention, comparat...

Jun 7th, 2019 - Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed. New data on imaging and clinical diagnosis have become available since the first EULAR recommendations for the diagnosis of gout in 2006. This prompted a...

Mar 8th, 2023 - This is a multi-center Phase 2/3 randomized, double-blind, placebo-controlled, parallel-group safety and efficacy study of dapansutrile (OLT1177®), a specific NLRP3 inhibitor, conducted in subjects with acute gout flare. Up to 300 eligible subject...

Mar 8th, 2023 - Approximately 180 participants will be enrolled. After a 4-week methotrexate run-in period, participants will be treated for up to 24 weeks with weekly oral methotrexate and biweekly 8mg pegloticase infusions. Up to three pegloticase infusion dura...

Mar 2nd, 2023 - The primary purpose of the study is to confirm the efficacy of dotinurad 4 milligram (mg) to febuxostat 40 mg on the percentage of participants achieving a serum uric acid (SUA) level less than or equal to (<=) 6.0 milligrams per deciliter (mg/dL)...

Mar 2nd, 2023 - Evidence shows independent associations between hyperuricaemia and the risk of hypertension, myocardial infarction, chronic kidney disease (CKD), type 2 diabetes, heart failure, and metabolic syndrome, including obesity Furthermore, gout, an infla...

Mar 1st, 2023 - D-0120 is being tested in combination with Allopurinol in adult subjects with Gout.

Mar 1st, 2023 - A panel of FDA’s outside advisors recommended the agency approve GSK’s respiratory syncytial virus (RSV) vaccine for older adults, a day after backing Pfizer’s RSV vaccine candidate for that same population. By votes of 12-0 on efficacy and 10-2 o...

Mar 1st, 2023 - A common diuretic wasn't much help for staving off recurrent kidney stones, the NOSTONE trial showed. Over a median follow-up of 2.9 years, symptomatic or radiologic recurrence of kidney stones occurred in 59% of patients who received hydrochlorot...

Feb 27th, 2023 - Ahead of a 2-day meeting with FDA's vaccine advisors, reviewers at the agency highlighted a rare but potential risk for Guillain-Barré syndrome with two vaccine candidates for respiratory syncytial virus (RSV). On Tuesday and Wednesday, the Vaccin...

Feb 3rd, 2023 - Sustained vigorous exercise might have slowed disease progression in two patients with positive Alzheimer's biomarkers and mild cognitive impairment, two case reports suggested. At age 64, patient 1 was diagnosed with amnestic mild cognitive impai...

Jan 20th, 2023 - An investigational non-purine xanthine oxidase inhibitor for gout treatment, called tigulixostat, appeared effective enough in a phase II trial that a pivotal study is now getting underway. Depending on the dose, 45% to 62% of patients receiving t...