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About 328,360 results
Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557428
PLoS Medicine; Shanthanna H, Gilron I et. al.

Aug 15th, 2017 - Chronic Low Back Pain (CLBP) is very common, with a lifetime prevalence between 51% and 80%. In majority, it is nonspecific in nature and multifactorial in etiology. Pregabalin (PG) and Gabapentin (GB) are gabapentinoids that have demonstrated benefit in neuropathic pain conditions. Despite no clear rationale, they are increasingly used for nonspecific CLBP. They necessitate prolonged use and a...

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
https://www.nejm.org/doi/full/10.1056/NEJMoa1912388?query=featured_home
New England Journal of Medicine; Tardif JC et al

Nov 16th, 2019 - Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis.

A Clinician's Guide to Healthy Eating for Cardiovascular Disease Prevention
https://www.acc.org/latest-in-cardiology/articles/2019/10/08/13/20/a-clinicians-guide-to-healthy-eating-for-cvd-prevention

Oct 7th, 2019 - The recently released 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease has given clinicians a comprehensive, evidence-based resource to inform management of patients at increased risk of atherosclerotic cardiovascular disease. In addition to guidance on risk stratification and medication prescribing, the Prevention Guideline stresses the importance of lifestyle interve...

FDA approves Rybelsus® (semaglutide), the first GLP-1 analog treatment available in a pill for adults with type 2 diabetes
https://www.novonordisk-us.com/media/news-releases.html?122973

Sep 19th, 2019 - Novo Nordisk today announced that the U.S. Food and Drug Administration (FDA) has approved Rybelsus® (semaglutide) tablets 7 mg or 14 mg for adults with type 2 diabetes that along with diet and exercise may improve blood sugar (glucose).1 Rybelsus® is the first and only glucagon-like peptide-1 (GLP-1) analog in a pill and a new option for adults with type 2 diabetes who are not achieving their ...

Unraveling the Safety Profile of Proton-Pump Inhibitors
https://www.jwatch.org/na49660/2019/08/19/unraveling-safety-profile-proton-pump-inhibitors
Journal Watch;

Aug 19th, 2019 - Proton-pump inhibitors (PPIs) provide important clinical benefits for many patients. However, observational studies have suggested an association between PPI use and a variety of adverse events, including dementia, osteoporosis, bone fractures, micronutrient deficiencies, pneumonia, spontaneous bacterial peritonitis, kidney disease, and enteric infections. We have observed that some patients wi...

Chronic Neck Pain: Nonpharmacologic Treatment
https://www.aafp.org/afp/2019/0801/p180.html
American Family Physician; Barreto, T. et. al.

Jul 31st, 2019 - Key Clinical Issue Which noninvasive nonpharmacologic treatments for chronic neck pain improve function or pain for at least one month? Evidence-Based Answer Combination exercise (including three of four exercise categories: muscle performance, mobility, muscle reeducation, and aerobic) slightly improves function and pain in the short term (one to less than six months). (Strength of Recomm...

Acupuncture for Pain
https://www.aafp.org/afp/2019/0715/p89.html
American Family Physician; Kelly, R. et. al.

Jul 14th, 2019 - Acupuncture has been increasingly used as an integrative or complementary therapy for pain. It is well-tolerated with little risk of serious adverse effects. Traditional acupuncture and nontraditional techniques, such as electroacupuncture and dry needling, often result in reported pain improvement. Multiple factors may contribute to variability in acupuncture's therapeutic effects, including n...

Arthritis Prevalence Statistics
https://www.rheumatology.org/Learning-Center/Statistics/Prevalence-Statistics

Jun 26th, 2019 - View overall prevalence of arthritis and rheumatic diseases as well as prevalence among specific racial and ethnic groups.

Teva Announces Launch of a Generic Version of Tracleer® (bosentan) Tablets in the United States
https://tevapharm.com/news/teva_announces_launch_of_a_generic_version_of_tracleer_bosentan_tablets_in_the_united_states_06_19.aspx

Jun 18th, 2019 - Teva Pharmaceutical Industries Ltd., (NYSE and TASE: TEVA) today announced the launch of a generic version of Tracleer®1 (bosentan) tablets, 62.5 mg and 125 mg, in the U.S. Bosentan Tablets are an endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group 1) in adults to improve exercise ability and to decrease worsening of the condition. P...

Health Insurance Design and Conservative Therapy for Low Back Pain
https://www.ajmc.com/journals/issue/2019/2019-vol25-n6/health-insurance-design-and-conservative-therapy-for-low-back-pain
The American Journal of Managed Care;

Jun 6th, 2019 - Objectives: To determine the association of health insurance benefit design features with choice of early conservative therapy for patients with new-onset low back pain (LBP). Study Design: Observational study of 117,448 commercially insured adults 18 years or older presenting with an outpatient diagnosis of new-onset LBP between 2008 and 2013 as recorded in the OptumLabs Data Warehouse. ...

Spinal Stenosis And Neurogenic Claudication - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK430872/
Munakomi, S. et. al.

Jun 3rd, 2019 - Approximately 90% of the population will present with low back pain at some point in their lifetime. Spinal stenosis is a condition that is caused by the narrowing of the central canal, the lateral recess, or neural foramen. This is a condition that can cause significant discomfort, interfere with activities of daily living, and may result in progressive disability.With increasing longevity of...

Varicose Veins: Diagnosis and Treatment.
https://www.aafp.org/afp/2019/0601/p682.html
American Family Physician; Raetz, J. et. al.

May 31st, 2019 - Varicose veins are twisted, dilated veins most commonly located on the lower extremities. The exact pathophysiology is debated, but it involves a genetic predisposition, incompetent valves, weakened vascular walls, and increased intravenous pressure. Risk factors include family history of venous disease; female sex; older age; chronically increased intra-abdominal pressure due to obesity, pregn...

Breast Cancer Risk Factors - breastcancer.org
https://www.breastcancer.org/risk/factors

May 31st, 2019 - Every woman wants to know what she can do to lower her risk of breast cancer. Some of the factors associated with breast cancer -- being a woman, your age, and your genetics, for example -- can't be changed. Other factors -- being overweight, lack of exercise, smoking cigarettes, and eating unhealthy food -- can be changed by making choices. By choosing the healthiest lifestyle options possible...

New WHO Guidelines recommend specific interventions for reducing the risk of cognitive decline and dementia
https://www.who.int/news-room/detail/14-05-2019-adopting-a-healthy-lifestyle-helps-reduce-the-risk-of-dementia

May 13th, 2019 - People can reduce their risk of dementia by getting regular exercise, not smoking, avoiding harmful use of alcohol, controlling their weight, eating a healthy diet, and maintaining healthy blood pressure, cholesterol and blood sugar levels, according to new guidelines issued by the World Health Organization (WHO) today.

Home-Based Cardiac Rehabilitation: A Scientific Statement From the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Heart Association, and the American College of C...
https://www.ahajournals.org/doi/pdf/10.1161/CIR.0000000000000663
Thomas, R. et. al.

May 11th, 2019 - Cardiac rehabilitation (CR) is an evidence-based intervention that uses patient education, health behavior modification, and exercise training to improve secondary prevention outcomes in patients with cardiovascular disease. CR programs reduce morbidity and mortality rates in adults with ischemic heart disease, heart failure, or cardiac surgery but are significantly underused, with only a minor...

Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors
https://www.ahajournals.org/doi/pdf/10.1161/CIR.0000000000000679

Apr 14th, 2019 - Cardiovascular disease is a competing cause of death in patients with cancer with early-stage disease. This elevated cardiovascular disease risk is thought to derive from both the direct effects of cancer therapies and the accumulation of risk factors such as hypertension, weight gain, cigarette smoking, and loss of cardiorespiratory fitness. Effective and viable strategies are needed to ...

Gelesis Granted FDA Clearance to Market PLENITY™ — a New Prescription Aid in Weight Management
https://www.gelesis.com/2019/04/14/gelesis-granted-fda-clearance-to-market-plenitytm-a-new-prescription-aid-to-weight-management/

Apr 13th, 2019 - Gelesis, a biotechnology company developing first-in-class hydrogel therapeutics to treat obesity and other chronic diseases related to the gastrointestinal (GI) tract, today announced that the United States Food and Drug Administration (FDA) has cleared the Company’s lead product candidate, PLENITY™ (Gelesis100), as an aid in weight management in adults with a Body Mass Index (BMI) of 25–40 k...

FDA Approves EVENITY™ (romosozumab-aqqg) For The Treatment Of Osteoporosis In Postmenopausal Women At High Risk For Fracture
https://wwwext.amgen.com/media/news-releases/2019/04/fda-approves-evenity-romosozumabaqqg-for-the-treatment-of-osteoporosis-in-postmenopausal-women-at-high-risk-for-fracture/

Apr 8th, 2019 - Amgen (NASDAQ: AMGN) and UCB (Euronext Brussels: UCB) today announced that the U.S. Food and Drug Administration (FDA) has approved EVENITY™ (romosozumab-aqqg) for the treatment of osteoporosis in postmenopausal women at high risk for fracture. EVENITY is the first and only bone builder with a unique dual effect that both increases bone formation and to a lesser extent reduces bone resorption (...

Diagnostic Tests for Low Back Disorders
https://acoem.org/acoem/media/PracticeResources/Diagnostic_Tests_for_Low_Back_Disorders-Apr-2019.pdf

Mar 31st, 2019 - This article summarizes ACOEM's evidence-based diagnostic guidelines for low back disorders. Recommendations are given for these diagnostic tests: functional capacity evaluations, roentgenograms (x-rays), magnetic resonance imaging (MRI), computerized tomography, myelography, bone scans, single proton emission computed tomography, electromyography, surface electromyography, ultrasound, thermogr.

TRILURON™ - P180040
https://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/Recently-ApprovedDevices/ucm635176.htm

Mar 25th, 2019 - TRILURON™ is a single-use syringe prefilled with sodium hyaluronate. Hyaluronate is a chemical found in the body, and it is present in joint tissues and in the fluid that fills the joints. The body's own hyaluronate acts like a lubricant and a shock absorber in the joint, and it is needed for the joint to work properly. In osteoarthritis, there may not be enough hyaluronate, and there may be a ...