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About 32,216 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  15,649 results

Genetic epidemiology of familial ALS in Brazil.
https://doi.org/10.1016/j.neurobiolaging.2021.01.007
Neurobiology of Aging; Nunes Gonçalves JP, Leoni TB et. al.

Feb 23rd, 2021 - Many genes associated with familial forms of the amyotrophic lateral sclerosis (fALS) have been identified in European and North American cohorts. However, little is known about the genetic bases of fALS in Latin America and Brazil, in particular....

Gastrointestinal biopsies and amyotrophic lateral sclerosis - results from a cohort stu...
https://doi.org/10.1080/21678421.2021.1883666
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; Sun J, Ludvigsson JF et. al.

Feb 23rd, 2021 - Background: Evidence has accumulated to support the involvement of gastrointestinal (GI) dysfunction, possibly via gut microbial dysbiosis and alterations in the enteric nervous system, in the pathophysiology of different neurodegenerative disease...

Spreading of pathological TDP-43 along corticospinal tract axons induces ALS-like pheno...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893595
International Journal of Biological Sciences; Zhang R, Chen Y et. al.

Feb 22nd, 2021 - Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by phosphorylated TDP-43 (pTDP-43)-positive inclusions in neurons and glial cells. However, the pathogenic mechanism that underlies ALS remains largely u...

Empathy-based supportive treatment in amyotrophic lateral sclerosis: A pragmatic study.
https://doi.org/10.1080/00029157.2020.1797623
The American Journal of Clinical Hypnosis; Palmieri A, Kleinbub JR et. al.

Feb 22nd, 2021 - Scarce literature has been dedicated to the psychological treatment of amyotrophic lateral sclerosis (ALS). However, there have been some encouraging findings, such as in hypnosis-based studies, which revealed patient improvements in anxiety, depr...

Role of extracellular vesicles in neurodegenerative diseases.
https://doi.org/10.1016/j.pneurobio.2021.102022
Progress in Neurobiology; Xiao Y, Wang SK et. al.

Feb 22nd, 2021 - Extracellular vesicles (EVs) are heterogeneous cell-derived membranous structures that arise from the endosome system or directly detach from the plasma membrane. In recent years, many advances have been made in the understanding of the clinical d...

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Guidelines  9 results

Aquestive Therapeutics Receives FDA Approval for Exservan (riluzole) Oral Film
http://aquestive.com/aquestive-therapeutics-receives-fda-approval-for-exservan-riluzole-oral-film/

Nov 24th, 2019 - Aquestive Therapeutics, Inc. (NASDAQ: AQST), a specialty pharmaceutical company focused on developing and commercializing differentiated products to solve therapeutic problems, today announced that Exservan™ (riluzole) Oral Film received early-act...

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 8th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

MDA U.S. Neuromuscular Disease Registry
https://www.mda.org/services/neuromuscular-disease-registry
Muscular Dystrophy Association (USA)

Dec 31st, 2015 - In 2013, MDA launched the U. S.

EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--rev...
https://doi.org/10.1111/j.1468-1331.2011.03501.x
European Journal of Neurology; , Andersen PM et. al.

Sep 14th, 2011 - The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak. To provide evidence-based or expert recommendations for the diagnosis and management of ALS based on a literature search and the consensus of an exp...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 13th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  31 results see all →

Clinicaltrials.gov  16,055 results

Genetic epidemiology of familial ALS in Brazil.
https://doi.org/10.1016/j.neurobiolaging.2021.01.007
Neurobiology of Aging; Nunes Gonçalves JP, Leoni TB et. al.

Feb 23rd, 2021 - Many genes associated with familial forms of the amyotrophic lateral sclerosis (fALS) have been identified in European and North American cohorts. However, little is known about the genetic bases of fALS in Latin America and Brazil, in particular....

Gastrointestinal biopsies and amyotrophic lateral sclerosis - results from a cohort stu...
https://doi.org/10.1080/21678421.2021.1883666
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; Sun J, Ludvigsson JF et. al.

Feb 23rd, 2021 - Background: Evidence has accumulated to support the involvement of gastrointestinal (GI) dysfunction, possibly via gut microbial dysbiosis and alterations in the enteric nervous system, in the pathophysiology of different neurodegenerative disease...

Spreading of pathological TDP-43 along corticospinal tract axons induces ALS-like pheno...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893595
International Journal of Biological Sciences; Zhang R, Chen Y et. al.

Feb 22nd, 2021 - Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by phosphorylated TDP-43 (pTDP-43)-positive inclusions in neurons and glial cells. However, the pathogenic mechanism that underlies ALS remains largely u...

Empathy-based supportive treatment in amyotrophic lateral sclerosis: A pragmatic study.
https://doi.org/10.1080/00029157.2020.1797623
The American Journal of Clinical Hypnosis; Palmieri A, Kleinbub JR et. al.

Feb 22nd, 2021 - Scarce literature has been dedicated to the psychological treatment of amyotrophic lateral sclerosis (ALS). However, there have been some encouraging findings, such as in hypnosis-based studies, which revealed patient improvements in anxiety, depr...

Role of extracellular vesicles in neurodegenerative diseases.
https://doi.org/10.1016/j.pneurobio.2021.102022
Progress in Neurobiology; Xiao Y, Wang SK et. al.

Feb 22nd, 2021 - Extracellular vesicles (EVs) are heterogeneous cell-derived membranous structures that arise from the endosome system or directly detach from the plasma membrane. In recent years, many advances have been made in the understanding of the clinical d...

see more →

News  453 results

After a Decade of Lobbying, ALS Patients Gain Faster Access to Disability Payments
https://www.medscape.com/viewarticle/944474

Jan 20th, 2021 - Anita Baron first noticed something was wrong in August 2018, when she began to drool. Her dentist chalked it up to a problem with her jaw. Then her speech became slurred. She managed to keep her company, which offers financing to small businesses...

VA Study Finds More ALS Hospitalizations With Edaravone
https://www.staging.medscape.com/viewarticle/938926

Oct 14th, 2020 - NEW YORK (Reuters Health) - Amyotrophic lateral sclerosis (ALS) patients prescribed edaravone are hospitalized more frequently, a new surveillance study in U.S. military veterans shows. Patients on edaravone had significantly higher rates of all-c...

VA Study Finds More ALS Hospitalizations With Edaravone
https://www.medscape.com/viewarticle/938926

Oct 14th, 2020 - NEW YORK (Reuters Health) - Amyotrophic lateral sclerosis (ALS) patients prescribed edaravone are hospitalized more frequently, a new surveillance study in U.S. military veterans shows. Patients on edaravone had significantly higher rates of all-c...

Drug Combo Slows Functional Decline in ALS
https://www.staging.medscape.com/viewarticle/936885

Sep 2nd, 2020 - Treatment with a fixed-dose combination of sodium phenylbutyrate and taurursodiol (AMX0035, Amylyx Pharmaceuticals) slows the rate of decline in physical function in patients with amyotrophic lateral sclerosis (ALS), according to results of the ph...

Drug Combo Slows Functional Decline in ALS
https://www.medscape.com/viewarticle/936885

Sep 2nd, 2020 - Treatment with a fixed-dose combination of sodium phenylbutyrate and taurursodiol (AMX0035, Amylyx Pharmaceuticals) slows the rate of decline in physical function in patients with amyotrophic lateral sclerosis (ALS), according to results of the ph...

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Patient Education  19 results see all →