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About 121,343 results

ALLMedicine™ Dementia Center

Research & Reviews  39,696 results

Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C
https://clinicaltrials.gov/ct2/show/NCT00344331

Jan 27th, 2023 - Niemann-Pick type C disease (NPC) is an autosomal recessive, lysosomal storage disorder characterized by accumulation of cholesterol and gangliosides. NPC is a rare (estimated prevalence of 1:120,000-150,000) neurodegenerative disorder with a wide...

Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging
https://clinicaltrials.gov/ct2/show/NCT04120766

Jan 27th, 2023 - The proposed project is a pilot clinical trial investigating a potential treatment for hippocampal sclerosis of aging (HS-Aging), a prevalent, high-morbidity mimic of Alzheimer's disease (AD). "AD mimics" (diseases with pathologies other than AD b...

AAV2-GDNF for Advanced Parkinson s Disease
https://clinicaltrials.gov/ct2/show/NCT01621581

Jan 27th, 2023 - Objective: While medications can temporarily alleviate the symptoms of Parkinson s disease (PD), they do not influence the degenerative process. Progressive loss of nigral dopaminergic (DA) neurons (the pathological hallmark of PD) results in prog...

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
https://clinicaltrials.gov/ct2/show/NCT03225144

Jan 27th, 2023 - Objectives The primary objective is to evaluate patients referred with a diagnosis of frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), or related adult-onset neurodegenerative disorders to assess patient eligibility for ongoing ...

Effect of Nordic Berries on Cognitive Function, Cardiometabolic Risk Markers and Gut Microbiota in Adults With Mild Cognitive Impairment
https://clinicaltrials.gov/ct2/show/NCT04317612

Jan 27th, 2023 - The study will be conducted with a randomized, double-blind, parallel-group (2 arms) placebo-controlled, single-center interventional design. The aim is to investigate the effects on cognitive function and cardiometabolic risk markers after 12 wee...

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Guidelines  48 results

Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study
https://www.bmj.com/content/380/bmj-2022-072691
BMJ Jia J, Zhao T et. al.

Jan 25th, 2023 - Although a fundamental function of daily life, memory continuously declines as people age,1 impairing both life quality and work productivity and increasing the risk of dementia.234 However, age related memory decline is not always a prodrome of d...

Healthy lifestyles for dementia prevention
https://www.bmj.com/content/380/bmj.p117
BMJ Sabia S, Singh-Manoux A.

Jan 25th, 2023 - Ageing is accompanied by a decline in several measures of cognitive function, such as memory, reasoning, and psychomotor speed. Differences in the rate of change in cognitive function can be substantial between individuals,1 highlighting the impor...

LEQEMBI Prescribing Information
https://www.leqembi.com/-/media/Files/Leqembi/Prescribing-Information.pdf

Jan 6th, 2023 - LEQEMBI is an amyloid beta-directed antibody indicated for the treatment of Alzheimer’s disease. Treatment with LEQEMBI should be initiated in patients with mild cognitive impairment or mild dementia stage of disease, the population in which tr...

Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer's Disease
https://www.sciencedirect.com/science/article/abs/pii/S0197458022002585
Neurobiology of Aging; Bubak AN, .

Dec 13th, 2022 - Alzheimer's disease (AD) is characterized by deficits in olfaction and olfactory pathology preceding diagnosis of dementia. Here we analyzed differential gene and protein expression in the olfactory bulb (OB) and tract (OT) of familial AD (FAD) in...

Brain vitamin D forms, cognitive decline, and neuropathology in community-dwelling older adults
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12836
Alzheimer's & Dementia; Shea MK, .

Dec 7th, 2022 - Vitamin D purportedly protects against cognitive decline and dementia based on observational data using circulating 25-hydroxyvitamin D (25(OH)D). Little is known about vitamin D in the human brain and the association with dementia or neuropathology.

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Drugs  398 results see all →

Clinicaltrials.gov  3,142 results

Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C
https://clinicaltrials.gov/ct2/show/NCT00344331

Jan 27th, 2023 - Niemann-Pick type C disease (NPC) is an autosomal recessive, lysosomal storage disorder characterized by accumulation of cholesterol and gangliosides. NPC is a rare (estimated prevalence of 1:120,000-150,000) neurodegenerative disorder with a wide...

Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging
https://clinicaltrials.gov/ct2/show/NCT04120766

Jan 27th, 2023 - The proposed project is a pilot clinical trial investigating a potential treatment for hippocampal sclerosis of aging (HS-Aging), a prevalent, high-morbidity mimic of Alzheimer's disease (AD). "AD mimics" (diseases with pathologies other than AD b...

AAV2-GDNF for Advanced Parkinson s Disease
https://clinicaltrials.gov/ct2/show/NCT01621581

Jan 27th, 2023 - Objective: While medications can temporarily alleviate the symptoms of Parkinson s disease (PD), they do not influence the degenerative process. Progressive loss of nigral dopaminergic (DA) neurons (the pathological hallmark of PD) results in prog...

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
https://clinicaltrials.gov/ct2/show/NCT03225144

Jan 27th, 2023 - Objectives The primary objective is to evaluate patients referred with a diagnosis of frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), or related adult-onset neurodegenerative disorders to assess patient eligibility for ongoing ...

Effect of Nordic Berries on Cognitive Function, Cardiometabolic Risk Markers and Gut Microbiota in Adults With Mild Cognitive Impairment
https://clinicaltrials.gov/ct2/show/NCT04317612

Jan 27th, 2023 - The study will be conducted with a randomized, double-blind, parallel-group (2 arms) placebo-controlled, single-center interventional design. The aim is to investigate the effects on cognitive function and cardiometabolic risk markers after 12 wee...

see more →

News  5,104 results

Primary Care Providers and Cognitive Health
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/361370

To facilitate national efforts to maintain cognitive health through public health practice, the Healthy Brain Initiative recommended examining diverse groups to identify stakeholder perspectives on cognitive health. In response, the Healthy Aging ...

More Antipsychotics Given for Dementia During Pandemic
https://www.medpagetoday.com/neurology/dementia/102837

Jan 26th, 2023 - Antipsychotic drug prescribing rates among people with dementia increased markedly during the early months of the COVID-19 pandemic, a multinational database study showed. Notably, those rates did not return to prepandemic levels after the acute p...

Memory Decline Tied to Lifestyle Factors
https://www.medpagetoday.com/neurology/alzheimersdisease/102811

Jan 25th, 2023 - Memory decline was slower for older adults who had a healthy lifestyle, even for people with high genetic risk for Alzheimer's disease, data from a Chinese study showed. People 60 and older who had at least four of six favorable lifestyle factors ...

Early CVD Linked to Accelerated Cognitive Decline
https://www.medpagetoday.com/cardiology/prevention/102803

Jan 25th, 2023 - Premature cardiovascular disease (CVD) was associated with accelerated decline in cognition and white matter health in midlife, a large prospective cohort study showed. On a composite cognitive score, those with CVD events before age 60 were more ...

Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study
https://www.bmj.com/content/380/bmj-2022-072691
BMJ Jia J, Zhao T et. al.

Jan 25th, 2023 - Although a fundamental function of daily life, memory continuously declines as people age,1 impairing both life quality and work productivity and increasing the risk of dementia.234 However, age related memory decline is not always a prodrome of d...

see more →

Patient Education  149 results see all →