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About 21,653 results

ALLMedicine™ Pulmonary Hypertension Center

Research & Reviews  7,744 results

Expanding ACTA2 genotypes with corresponding phenotypes overlapping with smooth muscle ...
https://doi.org/10.1002/ajmg.a.62775
American Journal of Medical Genetics. Part A; Kaw A, Kaw K et. al.

May 15th, 2022 - Pathogenic variants in ACTA2, encoding smooth muscle α-actin, predispose to thoracic aortic aneurysms and dissections. ACTA2 variants altering arginine 179 predispose to a more severe, multisystemic disease termed smooth muscle dysfunction syndrom...

Editorial for "Evaluation of Pulmonary Hypertension Using 4D Flow MRI".
https://doi.org/10.1002/jmri.28235
Journal of Magnetic Resonance Imaging : JMRI; Zhou Y, Panda A et. al.

May 15th, 2022 - Editorial for "Evaluation of Pulmonary Hypertension Using 4D Flow MRI".|2022|Zhou Y,Panda A,Jokerst CE,|

OSA and Chronic Respiratory Disease: Mechanisms and Epidemiology.
https://doi.org/10.3390/ijerph19095473
International Journal of Environmental Research and Publi... Locke BW, Lee JJ et. al.

May 15th, 2022 - Obstructive sleep apnea (OSA) is a highly prevalent disorder that has profound implications on the outcomes of patients with chronic lung disease. The hallmark of OSA is a collapse of the oropharynx resulting in a transient reduction in airflow, l...

COVID-19 in Patients with Pulmonary Hypertension: A National Prospective Cohort Study.
https://doi.org/10.1164/rccm.202112-2761OC
American Journal of Respiratory and Critical Care Medicine; Montani D, Certain MC et. al.

May 14th, 2022 - SARS-Cov2 infection is associated with pulmonary endothelial dysfunction. There is limited data available on the outcomes of COVID-19 in patients with pulmonary hypertension (PH), a disease characterized by pulmonary endothelial dysfunction. To de...

A dUTY to Protect: Addressing "Y" We See Sex Differences in Pulmonary Hypertension.
https://doi.org/10.1164/rccm.202204-0653ED
American Journal of Respiratory and Critical Care Medicine; Rao R, Chan SY

May 14th, 2022 - A dUTY to Protect: Addressing "Y" We See Sex Differences in Pulmonary Hypertension.|2022|Rao R,Chan SY,|

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Guidelines  18 results

Evaluation and management of patients with chronic thromboembolic pulmonary hypertensio...
https://doi.org/10.1016/j.healun.2021.07.020
The Journal of Heart and Lung Transplantation : the Offic... de Perrot M, Gopalan D et. al.

Aug 24th, 2021 - ISHLT members have recognized the importance of a consensus statement on the evaluation and management of patients with chronic thromboembolic pulmonary hypertension. The creation of this document required multiple steps, including the engagement ...

ISHLT consensus document on lung transplantation in patients with connective tissue dis...
https://doi.org/10.1016/j.healun.2021.07.016
The Journal of Heart and Lung Transplantation : the Offic... Bermudez CA, Crespo MM et. al.

Aug 19th, 2021 - Patients with connective tissue disease (CTD) present unique surgical, perioperative, operative, and postoperative challenges related to the often underlying severe pulmonary hypertension and right ventricular dysfunction. The International Societ...

Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism.
https://doi.org/10.1210/clinem/dgaa543
The Journal of Clinical Endocrinology and Metabolism; Brar PC, Heksch R et. al.

Aug 19th, 2020 - The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade. Diazoxide is the only Food and Drug Agency-approved pharmacologic treatment for neonatal hypoglycemia caused by hyperinsulinism (HI). Recent publications have hi...

Canadian Cardiovascular Society/Canadian Thoracic Society Position Statement on Pulmona...
https://doi.org/10.1016/j.cjca.2019.11.041
The Canadian Journal of Cardiology; Hirani N, Brunner NW et. al.

Jul 20th, 2020 - The landscape of pulmonary hypertension (PH) has changed significantly since the last Canadian Cardiovascular Society/Canadian Thoracic Society position statement in 2005. Since then, advances in our understanding of the pathophysiology of PH and ...

Canadian Cardiovascular Society/Canadian Cardiac Transplant Network Position Statement ...
https://doi.org/10.1016/j.cjca.2019.12.025
The Canadian Journal of Cardiology; Chih S, McDonald M et. al.

Mar 9th, 2020 - Significant practice-changing developments have occurred in the care of heart transplantation candidates and recipients over the past decade. This Canadian Cardiovascular Society/Canadian Cardiac Transplant Network Position Statement provides evid...

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Drugs  39 results see all →

Clinicaltrials.gov  343 results

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT00011648

May 13th, 2022 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

Impact of Multiple Doses of BAY63-2521 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Patients With Interstitial Lung Disease (ILD) Associated Pulmonary Hypertension (PH)
https://clinicaltrials.gov/ct2/show/NCT00694850

May 12th, 2022 - The purpose of this study is to assess multiple ascending doses of a new drug (BAY63-2521) given orally, to evaluate if it is safe and can help to improve the well-being, symptoms (e.g. disturbed breathing) and outcome of pulmonary hypertension as...

Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension
https://clinicaltrials.gov/ct2/show/NCT04039464

May 11th, 2022 - A Phase III, randomized, open label, pragmatic trial to compare the safety and efficacy of first-line combination therapy (sildenafil and bosentan) to first-line monotherapy (sildenafil alone) in pediatric subjects with WHO Functional Classes II o...

Genetic and Environmental Determinants That Control Metabolism in Pulmonary Hypertension
https://clinicaltrials.gov/ct2/show/NCT02594917

May 11th, 2022 - Test group: The study will include two visits for the test group: At visit one there will be required and optional research activities as the following: Required research activities: -Peripheral blood draw (3.5 tablespoons) drawn by research coord...

Aerobic Exercise in Women With Systemic Lupus Erythematosus
https://clinicaltrials.gov/ct2/show/NCT03186794

May 10th, 2022 - We propose a single-arm exploratory study to characterize the responses and adaptations to aerobic exercise in women who have mild to moderate systemic lupus erythematosus (SLE) uncomplicated by organ damage that would limit participation. This is...

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News  496 results

'Voice Biomarker' Shows Progress in CAD Risk Assessment
https://www.medscape.com/viewarticle/971356

Mar 31st, 2022 - Vocal characteristics that can't actually be heard, discernible only by computer, might help identify individuals with confirmed or suspected heart disease who are at increased risk for a cardiovascular (CV) event over the next several years, a pr...

FDA Approvals, Highlights, and Summaries: Pulmonology 
https://reference.medscape.com/viewarticle/967617

Feb 17th, 2022 - Tezspire (tezepelumab) Tezepelumab is a first-in-class human monoclonal antibody immunoglobulin G2-lambda that inhibits thymic stromal lymphopoietin (TSLP). It is indicated for add-on maintenance treatment of severe asthma in adults and pediatric ...

FDA Approvals, Highlights, and Summaries: Pulmonology 
https://www.medscape.com/viewarticle/967617

Feb 17th, 2022 - Tezspire (tezepelumab) Tezepelumab is a first-in-class human monoclonal antibody immunoglobulin G2-lambda that inhibits thymic stromal lymphopoietin (TSLP). It is indicated for add-on maintenance treatment of severe asthma in adults and pediatric ...

PAH care turns corner with new therapies, intensified monitoring
https://www.mdedge.com/chestphysician/article/251541/pulmonology/pah-care-turns-corner-new-therapies-intensified-monitoring
Christine Kilgore, MDedge News

Feb 8th, 2022 - Aggressive up-front combination therapy, more lofty treatment goals, and earlier and more frequent reassessments to guide treatment are improving care of patients with pulmonary arterial hypertension (PAH) while at the same time making it more com.

Identifying Severe Pulmonary Hypertension in Patients With COPD 
https://www.medscape.com/viewarticle/967874

Feb 3rd, 2022 - Patients with severe pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD) can now be identified using three widely available clinical variables, all of which can be measured non-invasively, a single-center, retrospective an...

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Patient Education  21 results see all →