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ALLMedicine™ Breast Cancer Center

Research & Reviews  178,785 results

CDK4/6 inhibition promotes anti-tumor immunity through the induction of T cell memory.
https://doi.org/10.1158/2159-8290.CD-20-1554
Cancer Discovery; Lelliott EJ, Kong IY et. al.

May 15th, 2021 - Pharmacological inhibitors of cyclin dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor-positive breast cancer and are currently under evaluation across hundreds of clinical trials for other cancer types. The clinica...

Obesity Promotes Metastasis via Neutrophil-Mediated Vascular Damage.
https://doi.org/10.1158/2159-8290.CD-RW2021-068
Cancer Discovery;

May 15th, 2021 - Obesity compromised vascular integrity, enhancing breast cancer extravasation during metastasis.

Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and...
https://doi.org/10.1136/jim-2021-001836
Journal of Investigative Medicine : the Official Publicat... Peng J, Zhang D

May 15th, 2021 - This study investigated the influences of EphA10 and Gli3 on breast cancer (BC) cell proliferation, invasion and migration. Immunohistochemistry was used to reveal the expressions of EphA10 and Gli3 in 18 intraductal carcinomas, 124 invasive carci...

Value of 18F-FES-PET to solve clinical dilemmas in breast cancer patients: a retrospect...
https://doi.org/10.2967/jnumed.120.256826
Journal of Nuclear Medicine : Official Publication, Socie... Boers J, Loudini N et. al.

May 15th, 2021 - Background: Breast cancer (BC) is a heterogeneous disease, in which estrogen receptor (ER) expression plays an important role in the majority of breast tumors. A clinical dilemma may arise when a metastasis biopsy to determine the ER status cannot...

SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell...
https://doi.org/10.1186/s13046-021-01933-7 10.3322/caac.21654 10.3390/cancers12092392 10.1186/s12943-019-1089-9 10.1016/j.tcb.2014.06.001 10.1038/s12276-020-0384-2 10.1002/jcp.25349 10.1042/BJ20081386 10.1038/emm.2016.119 10.1038/nrc3803 10.1016/j.cmet.2009.08.015 10.1016/j.mam.2015.12.001 10.1186/s40880-018-0288-x 10.1371/journal.pone.0016187 10.3389/fphys.2018.00773 10.1016/j.biochi.2015.10.022 10.1016/j.redox.2019.101387 10.1177/1533033820983029 10.1152/physrev.2000.80.3.1107 10.1016/j.cell.2014.12.018 10.1016/j.biocel.2013.02.003 10.1016/j.immuni.2019.06.007 10.1016/j.trecan.2016.10.016 10.1080/17460441.2019.1613370 10.1186/1476-4598-2-23 10.1523/JNEUROSCI.1941-16.2016 10.1016/j.redox.2017.02.012 10.1007/s00018-018-2779-y 10.1007/s00726-011-0875-5 10.1016/j.cmet.2020.10.002 10.1016/S0168-8278(97)80183-3 10.1210/jcem.83.7.4949 10.1083/jcb.200512100 10.1002/ijc.25817 10.1016/j.canlet.2020.12.020 10.1155/2016/3907147 10.1016/j.ccell.2020.06.001 10.1158/1078-0432.CCR-15-1987 10.1038/ncomms9468 10.1016/j.tibs.2014.06.005 10.1158/1541-7786.MCR-18-0315 10.1016/j.freeradbiomed.2005.10.035 10.1016/j.bbagen.2007.09.018 10.1016/j.mrfmmm.2009.07.005 10.1186/1550-2783-7-9 10.1007/s00395-012-0268-2 10.1016/j.mam.2016.01.002 10.1093/brain/awr261 10.1016/j.cmet.2011.10.008 10.1007/s00018-009-0099-y 10.1016/j.canlet.2016.03.042 10.1089/ars.2011.4414 10.1016/j.biomaterials.2015.03.047 10.1073/pnas.1508779113 10.1016/j.canlet.2020.04.003
Journal of Experimental & Clinical Cancer Research : CR; Li Q, Liu M et. al.

May 15th, 2021 - Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with poor prognosis and limited treatment options. Hypoxia is a key hallmark of TNBC. Metabolic adaptation promotes progression of TNBC cells that are located wi...

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Guidelines  893 results

Breastfeeding Challenges: ACOG Committee Opinion, Number 820.
https://doi.org/10.1097/AOG.0000000000004253
Obstetrics and Gynecology;

Jan 22nd, 2021 - Breastfeeding is associated with a decrease in a woman's risk of breast cancer, ovarian cancer, diabetes mellitus, and hypertensive heart disease. Breastfeeding initiation rates in the United States are increasing, and many women are aware of the ...

Real-World Experiences With Yoga on Cancer-Related Symptoms in Women With Breast Cancer
https://pubmed.ncbi.nlm.nih.gov/33473331/
Global Advances in Health and Medicine; Patel SR, Zayas J et. al.

Jan 6th, 2021 - Integrative therapies such as yoga are potential treatments for many psychological and physical symptoms that occur during and/or after treatment for cancer. The purpose of the current study was to evaluate the patient-perceived benefit of yoga fo...

Breast conservation and axillary management after primary systemic therapy in patients ...
https://doi.org/10.1016/S1470-2045(20)30580-5
The Lancet. Oncology; Dubsky P, Pinker K et. al.

Jan 2nd, 2021 - Primary systemic therapy is increasingly used in the treatment of patients with early-stage breast cancer, but few guidelines specifically address optimal locoregional therapies. Therefore, we established an international consortium to discuss cli...

Breast cancer risk factors and their effects on survival: a Mendelian randomisation study
https://pubmed.ncbi.nlm.nih.gov/33198768/
BMC Medicine; Escala-Garcia M

Nov 16th, 2020 - Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to potential residual confounding. Using a Mend...

ACR Appropriateness Criteria® Imaging After Mastectomy and Breast Reconstruction.
https://doi.org/10.1016/j.jacr.2020.09.009
Journal of the American College of Radiology : JACR; , Heller SL et. al.

Nov 6th, 2020 - Mastectomy may be performed to treat breast cancer or as a prophylactic approach in women with a high risk of developing breast cancer. In addition, mastectomies may be performed with or without reconstruction. Reconstruction approaches differ and...

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Drugs  989 results see all →

Clinicaltrials.gov  195,467 results

CDK4/6 inhibition promotes anti-tumor immunity through the induction of T cell memory.
https://doi.org/10.1158/2159-8290.CD-20-1554
Cancer Discovery; Lelliott EJ, Kong IY et. al.

May 15th, 2021 - Pharmacological inhibitors of cyclin dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor-positive breast cancer and are currently under evaluation across hundreds of clinical trials for other cancer types. The clinica...

Obesity Promotes Metastasis via Neutrophil-Mediated Vascular Damage.
https://doi.org/10.1158/2159-8290.CD-RW2021-068
Cancer Discovery;

May 15th, 2021 - Obesity compromised vascular integrity, enhancing breast cancer extravasation during metastasis.

Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and...
https://doi.org/10.1136/jim-2021-001836
Journal of Investigative Medicine : the Official Publicat... Peng J, Zhang D

May 15th, 2021 - This study investigated the influences of EphA10 and Gli3 on breast cancer (BC) cell proliferation, invasion and migration. Immunohistochemistry was used to reveal the expressions of EphA10 and Gli3 in 18 intraductal carcinomas, 124 invasive carci...

Value of 18F-FES-PET to solve clinical dilemmas in breast cancer patients: a retrospect...
https://doi.org/10.2967/jnumed.120.256826
Journal of Nuclear Medicine : Official Publication, Socie... Boers J, Loudini N et. al.

May 15th, 2021 - Background: Breast cancer (BC) is a heterogeneous disease, in which estrogen receptor (ER) expression plays an important role in the majority of breast tumors. A clinical dilemma may arise when a metastasis biopsy to determine the ER status cannot...

SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell...
https://doi.org/10.1186/s13046-021-01933-7 10.3322/caac.21654 10.3390/cancers12092392 10.1186/s12943-019-1089-9 10.1016/j.tcb.2014.06.001 10.1038/s12276-020-0384-2 10.1002/jcp.25349 10.1042/BJ20081386 10.1038/emm.2016.119 10.1038/nrc3803 10.1016/j.cmet.2009.08.015 10.1016/j.mam.2015.12.001 10.1186/s40880-018-0288-x 10.1371/journal.pone.0016187 10.3389/fphys.2018.00773 10.1016/j.biochi.2015.10.022 10.1016/j.redox.2019.101387 10.1177/1533033820983029 10.1152/physrev.2000.80.3.1107 10.1016/j.cell.2014.12.018 10.1016/j.biocel.2013.02.003 10.1016/j.immuni.2019.06.007 10.1016/j.trecan.2016.10.016 10.1080/17460441.2019.1613370 10.1186/1476-4598-2-23 10.1523/JNEUROSCI.1941-16.2016 10.1016/j.redox.2017.02.012 10.1007/s00018-018-2779-y 10.1007/s00726-011-0875-5 10.1016/j.cmet.2020.10.002 10.1016/S0168-8278(97)80183-3 10.1210/jcem.83.7.4949 10.1083/jcb.200512100 10.1002/ijc.25817 10.1016/j.canlet.2020.12.020 10.1155/2016/3907147 10.1016/j.ccell.2020.06.001 10.1158/1078-0432.CCR-15-1987 10.1038/ncomms9468 10.1016/j.tibs.2014.06.005 10.1158/1541-7786.MCR-18-0315 10.1016/j.freeradbiomed.2005.10.035 10.1016/j.bbagen.2007.09.018 10.1016/j.mrfmmm.2009.07.005 10.1186/1550-2783-7-9 10.1007/s00395-012-0268-2 10.1016/j.mam.2016.01.002 10.1093/brain/awr261 10.1016/j.cmet.2011.10.008 10.1007/s00018-009-0099-y 10.1016/j.canlet.2016.03.042 10.1089/ars.2011.4414 10.1016/j.biomaterials.2015.03.047 10.1073/pnas.1508779113 10.1016/j.canlet.2020.04.003
Journal of Experimental & Clinical Cancer Research : CR; Li Q, Liu M et. al.

May 15th, 2021 - Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with poor prognosis and limited treatment options. Hypoxia is a key hallmark of TNBC. Metabolic adaptation promotes progression of TNBC cells that are located wi...

see more →

News  13,643 results

Follow-up Sinks Candesartan as Cardioprotection in Breast Cancer
https://www.medscape.com/viewarticle/951242

May 15th, 2021 - After a modest early signal of benefit, candesartan cilexetil (Atacand, Cheplapharm) showed no effect on key markers of heart health 2 years after treatment in patients with early-stage breast cancer in the randomized PRADA trial. The 2015 study w...

BERENICE: Further Evidence of Heart Safety of Dual HER2 Blockade
https://www.medscape.com/viewarticle/951160

May 13th, 2021 - Dual HER2 blockade with pertuzumab (Perjeta) and trastuzumab (Herceptin) on top of anthracycline-based neoadjuvant chemotherapy for early-stage breast cancer was associated with a low rate of clinically relevant cardiac events in the final follow-...

Better Survival After Lumpectomy Plus RT vs Mastectomy
https://www.medscape.com/viewarticle/950803

May 9th, 2021 - Overall survival and breast cancer–specific survival were consistently better for women with early breast cancer who were treated with breast conservation surgery (BCS) followed by radiotherapy (RT) compared to women who were treated with mastecto...

Freezing Breast Cancer to Death Avoids Surgery
https://www.medscape.com/viewarticle/950821

May 9th, 2021 - In the United States, cryoablation or freezing tissue to death is a primary treatment option for a variety of cancers, including those originating in or spread to the bone, cervix, eye, kidney, liver, lung, pancreas, prostate, and skin. Cryoablati...

COVID Impact on Breast Cancer: Upfront Endocrine Rx Increased
https://www.medscape.com/viewarticle/950624

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The use of neoadjuvant endocrine therapy (NET) increased significantly during the first 8 months of the COVID-19 pandemic for women with estrogen ...

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Patient Education  283 results see all →