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About 231 results

ALLMedicine™ Pediatric Osteosarcoma Center

Research & Reviews  115 results

Adjuvant sirolimus does not improve outcome in pet dogs receiving standard of care ther...
https://doi.org/10.1158/1078-0432.CCR-21-0315
Clinical Cancer Research : an Official Journal of the Ame... LeBlanc AK, Mazcko CN et. al.

Mar 23rd, 2021 - The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition of mTOR signaling is biologically-achievable with sirolimus, and might slow the outgrowth of di...

Retrospective analysis of high-dose chemotherapy followed by autologous stem cell trans...
https://doi.org/10.1080/08880018.2020.1729906
Pediatric Hematology and Oncology; Uemura S, Mori T et. al.

Mar 10th, 2020 - The outcomes of osteosarcoma with poor prognostic factors, such as poor responders, metastatic disease at diagnosis, and relapsed or refractory disease, are poor. We reviewed the clinical records of the patients diagnosed with osteosarcoma at our ...

Risk factors associated with delayed methotrexate clearance and increased toxicity in p...
https://doi.org/10.1002/pbc.28123
Pediatric Blood & Cancer REFERENCES; Young EP, Cheng WS et. al.

Dec 23rd, 2019 - High-dose methotrexate (HD-MTX; 12 g/m2 ) is part of standard therapy for pediatric osteosarcoma (OS). Risk factors associated with MTX toxicity in children with OS are not well defined. We investigated the association between peak MTX levels (fou...

Joint-preservation surgery for pediatric osteosarcoma of the knee joint.
https://doi.org/10.1007/s10555-019-09835-z
Cancer Metastasis Reviews; Takeuchi A, Yamamoto N et. al.

Dec 6th, 2019 - The multi-disciplinary approach involving imaging, multi-agent chemotherapy, meticulous surgical procedures, and careful postoperative care has facilitated an increase in the use of limb-sparing surgery for pediatric osteosarcoma. Osteosarcoma usu...

Prexasertib (LY2606368) reduces clonogenic survival by inducing apoptosis in primary pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384073
International Journal of Cancer; Heidler CL, Roth EK et. al.

Nov 29th, 2019 - Progress in the systemic control of osteosarcoma has been limited over the past decades thus indicating the urgent clinical need for the development of novel treatment strategies. Therefore, we have recently developed new preclinical models to stu...

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Clinicaltrials.gov  115 results

Adjuvant sirolimus does not improve outcome in pet dogs receiving standard of care ther...
https://doi.org/10.1158/1078-0432.CCR-21-0315
Clinical Cancer Research : an Official Journal of the Ame... LeBlanc AK, Mazcko CN et. al.

Mar 23rd, 2021 - The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition of mTOR signaling is biologically-achievable with sirolimus, and might slow the outgrowth of di...

Retrospective analysis of high-dose chemotherapy followed by autologous stem cell trans...
https://doi.org/10.1080/08880018.2020.1729906
Pediatric Hematology and Oncology; Uemura S, Mori T et. al.

Mar 10th, 2020 - The outcomes of osteosarcoma with poor prognostic factors, such as poor responders, metastatic disease at diagnosis, and relapsed or refractory disease, are poor. We reviewed the clinical records of the patients diagnosed with osteosarcoma at our ...

Risk factors associated with delayed methotrexate clearance and increased toxicity in p...
https://doi.org/10.1002/pbc.28123
Pediatric Blood & Cancer REFERENCES; Young EP, Cheng WS et. al.

Dec 23rd, 2019 - High-dose methotrexate (HD-MTX; 12 g/m2 ) is part of standard therapy for pediatric osteosarcoma (OS). Risk factors associated with MTX toxicity in children with OS are not well defined. We investigated the association between peak MTX levels (fou...

Joint-preservation surgery for pediatric osteosarcoma of the knee joint.
https://doi.org/10.1007/s10555-019-09835-z
Cancer Metastasis Reviews; Takeuchi A, Yamamoto N et. al.

Dec 6th, 2019 - The multi-disciplinary approach involving imaging, multi-agent chemotherapy, meticulous surgical procedures, and careful postoperative care has facilitated an increase in the use of limb-sparing surgery for pediatric osteosarcoma. Osteosarcoma usu...

Prexasertib (LY2606368) reduces clonogenic survival by inducing apoptosis in primary pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384073
International Journal of Cancer; Heidler CL, Roth EK et. al.

Nov 29th, 2019 - Progress in the systemic control of osteosarcoma has been limited over the past decades thus indicating the urgent clinical need for the development of novel treatment strategies. Therefore, we have recently developed new preclinical models to stu...

see more →

News  1 results

From the journals: sarcoma around the world
https://www.mdedge.com/sarcomajournal/article/203054/sarcoma/journals-sarcoma-around-world/page/0/2?channel=50183

Jun 17th, 2019 - PEDIATRIC OSTEOSARCOMA IN LEBANON: Investigators at a single institution in Lebanon reported a similar survival rate for newly diagnosed patients with pediatric osteosarcoma treated at their center as for those treated in more developed countries.

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