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About 3,638 results

ALLMedicine™ Anal Cancer Center

Research & Reviews  1,081 results

HPV virus and biomarkers of resistance to chemoradiation in circulating tumor cells fro...
https://doi.org/10.1016/j.prp.2023.154327
Pathology, Research and Practice; Ruano APC, de Jesus Ferreira Costa D et. al.

Feb 3rd, 2023 - Localized anal cancer is mostly represented by squamous cell carcinoma of the anus (SCCA) and is cured in ≥80 % of cases by chemoradiation (CRT). Development of techniques for detection/evaluating circulating tumor cells (CTCs) for diagnosis/ prog...

AUTOMATED IN VIVO HIGH-RESOLUTION IMAGING TO DETECT HPV-ASSOCIATED ANAL PRECANCER IN PE...
https://doi.org/10.14309/ctg.0000000000000558
Clinical and Translational Gastroenterology; Brenes D, Kortum A et. al.

Feb 3rd, 2023 - In the United States, the effectiveness of anal cancer screening programs has been limited by a lack of trained professionals proficient in high-resolution anoscopy (HRA) and a high patient lost-to-follow-up rate between diagnosis and treatment. S...

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer
https://clinicaltrials.gov/ct2/show/NCT03233711

Jan 31st, 2023 - PRIMARY OBJECTIVE: I. To evaluate whether therapy with nivolumab following combined modality therapy (CMT) improves disease-free survival (DFS) compared with observation in patients with high risk anal carcinoma. SECONDARY OBJECTIVES: I. To compar...

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients
https://clinicaltrials.gov/ct2/show/NCT04444921

Jan 31st, 2023 - PRIMARY OBJECTIVE: I. To demonstrate that anti-PD-1 therapy in combination with carboplatin/weekly paclitaxel results in improved progression-free survival (PFS) versus systemic chemotherapy alone. SECONDARY OBJECTIVES: I. To demonstrate that anti...

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer
https://clinicaltrials.gov/ct2/show/NCT04929028

Jan 30th, 2023 - PRIMARY OBJECTIVES: I. To determine the safety of reduced intensity chemo-radiation therapy (CRT) in low-risk disease. II. To determine the safety of nivolumab after standard CRT in high-risk disease. SECONDARY OBJECTIVES: I. To estimate the effic...

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Guidelines  8 results

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT...
https://doi.org/10.1016/j.prro.2022.01.015
Practical Radiation Oncology; Damico N, Meyer J et. al.

Jun 19th, 2022 - Previous anal cancer guidelines delineate target volumes similarly for all patients with squamous cell carcinoma of the anal canal and/or perianal skin (SCCA), regardless of disease stage. The purpose of this guideline is to provide customized rad...

Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up☆.
https://doi.org/10.1016/j.annonc.2021.06.015
Annals of Oncology : Official Journal of the European Soc... Rao S, Guren MG et. al.

Jun 28th, 2021 - Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up☆.|2021|Rao S,Guren MG,Khan K,Brown G,Renehan AG,|diagnosis,epidemiology,therapy,

Cancer in People Living With HIV, Version 1.2018, NCCN Clinical Practice Guidelines in ...
https://doi.org/10.6004/jnccn.2018.0066
Journal of the National Comprehensive Cancer Network : JN... Reid E, Suneja G et. al.

Aug 14th, 2018 - People living with HIV (PLWH) are diagnosed with cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced cancer stage, comorbidities, immunosuppression, and cancer treatment ...

Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
https://doi.org/10.6004/jnccn.2018.0060
Journal of the National Comprehensive Cancer Network : JN... Benson AB, Venook AP et. al.

Jul 15th, 2018 - The NCCN Guidelines for Anal Carcinoma provide recommendations for the management of patients with squamous cell carcinoma of the anal canal or perianal region. Primary treatment of anal cancer usually includes chemoradiation, although certain les...

2016 IANS International Guidelines for Practice Standards in the Detection of Anal Canc...
https://doi.org/10.1097/LGT.0000000000000256
Journal of Lower Genital Tract Disease; Hillman RJ, Cuming T et. al.

Aug 26th, 2016 - To define minimum standards for provision of services and clinical practice in the investigation of anal cancer precursors. After initial face to face meetings of experts at the International Papillomavirus meeting in Lisbon, September 17 to 21, 2...

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Drugs  2 results see all →

Clinicaltrials.gov  132 results

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer
https://clinicaltrials.gov/ct2/show/NCT03233711

Jan 31st, 2023 - PRIMARY OBJECTIVE: I. To evaluate whether therapy with nivolumab following combined modality therapy (CMT) improves disease-free survival (DFS) compared with observation in patients with high risk anal carcinoma. SECONDARY OBJECTIVES: I. To compar...

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients
https://clinicaltrials.gov/ct2/show/NCT04444921

Jan 31st, 2023 - PRIMARY OBJECTIVE: I. To demonstrate that anti-PD-1 therapy in combination with carboplatin/weekly paclitaxel results in improved progression-free survival (PFS) versus systemic chemotherapy alone. SECONDARY OBJECTIVES: I. To demonstrate that anti...

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer
https://clinicaltrials.gov/ct2/show/NCT04929028

Jan 30th, 2023 - PRIMARY OBJECTIVES: I. To determine the safety of reduced intensity chemo-radiation therapy (CRT) in low-risk disease. II. To determine the safety of nivolumab after standard CRT in high-risk disease. SECONDARY OBJECTIVES: I. To estimate the effic...

Safety Study of BMX-001 (Radio-protector) in Patients With Newly Diagnosed Anal Cancer
https://clinicaltrials.gov/ct2/show/NCT03386500

Jan 25th, 2023 - In this Phase 1/2 study, the investigators will conduct a safety and efficacy study of the combination of BMX-001 with standard radiation therapy (RT) and concurrent 5-fluorouracil (5FU)/mitomycin in newly diagnosed Anal Squamous Cell Carcinoma (A...

Reconstruction After Abdominoperineal Resection With Robot-assisted Harvest of VRAM Flap
https://clinicaltrials.gov/ct2/show/NCT05689775

Jan 19th, 2023 - Inclusion criteria: Patients > 18 years of age operated with robotic-assisted abdominoperineal resection for irradiated locally advanced rectal or anal cancer where robotic-assisted perineal and/or vaginal reconstruction has been performed with a ...

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News  207 results

For People With HIV, Early Anal Cancer Screening Tied to Better Outcomes
https://www.medpagetoday.com/hivaids/hivaids/102643

Jan 13th, 2023 - Screening HIV-positive individuals for early signs of anal cancer may lead to an earlier diagnosis and better survival, according to an observational Dutch cohort study. Among men who have sex with men (MSM) living with HIV, anal cancer-related mo...

High Response Rate With Neoadjuvant Anti-PD-1 in Localized dMMR Colorectal Cancer
https://www.medpagetoday.com/hematologyoncology/coloncancer/102615

Jan 12th, 2023 - Neoadjuvant immunotherapy with PD-1 inhibitors led to objective responses in 85% of patients with localized and locally advanced colorectal cancer (CRC) with mismatch repair deficiency (dMMR)/high microsatellite instability (MSI-H), a retrospectiv...

CUE-101 Gets Fast Tracked for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
https://www.onclive.com/view/cue-101-gets-fast-tracked-for-recurrent-metastatic-head-and-neck-squamous-cell-carcinoma

Oct 5th, 2022 - The FDA has granted a fast track designation to CUE-101 for use as a monotherapy and in combination with pembrolizumab (Keytruda) in patients with human papillomavirus (HPV16+) recurrent or metastatic head and neck squamous cell carcinoma (HNSCC)....

Noninvasive Gastric Mapping; Best Foods for the Gut? Lab Score for Crohn's
https://www.medpagetoday.com/gastroenterology/generalgastroenterology/100867

Sep 22nd, 2022 - Could a novel noninvasive gastric mapping device that measures stomach activity offer new insights into chronic nausea and vomiting? (Science Translational Medicine) Vedolizumab (Entyvio) and ustekinumab (Stelara) were both highly effective as thi...

Zanidatamab Zovodotin Showcases Promising Safety, Activity in HER2+ Solid Cancers
https://www.onclive.com/view/zanidatamab-zovodotin-showcases-promising-safety-activity-in-her2-solid-cancers

Sep 21st, 2022 - Zanidatamab zovodotin (ZW49) was found to produce encouraging responses and to have a manageable toxicity profile when used as a monotherapy in heavily pretreated patients with HER2-positive solid cancers, according to data from a first-in-human p...

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Patient Education  25 results see all →