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About 16,945 results

ALLMedicine™ Rectal Cancer Center

Research & Reviews  6,036 results

Nonoperative Management for Rectal Cancer.
https://doi.org/10.1016/j.hoc.2022.03.003
Hematology/oncology Clinics of North America; Quezada-Diaz FF, Smith JJ

May 14th, 2022 - The treatment algorithm for locally advanced rectal cancer (LARC) has increased in complexity over the past 10 years. Nonoperative management (NOM) for rectal cancer in patients with clinical complete response (cCR) after neoadjuvant therapy has b...

The Multimodal Management of Locally Advanced Rectal Cancer: Making Sense of the New Data.
https://doi.org/10.1200/EDBK_351411
American Society of Clinical Oncology Educational Book. A... Zwart WH, Hotca A et. al.

May 14th, 2022 - In the past 40 years, the treatment of locally advanced rectal cancer has evolved with the addition of radiotherapy or chemoradiotherapy and providing (neo)adjuvant systemic chemotherapy to major surgery. However, recent trends have focused on imp...

DNA Mismatch Repair-deficient Rectal Cancer Is Frequently Associated With Lynch Syndrom...
https://doi.org/10.1097/PAS.0000000000001918
The American Journal of Surgical Pathology; Farchoukh LF, Celebrezze J et. al.

May 14th, 2022 - We evaluated 368 consecutively resected rectal cancers with neoadjuvant therapy for DNA mismatch repair (MMR) protein status, tumor response to neoadjuvant therapy, histopathologic features, and patient survival. Nine (2.4%) rectal cancers were mi...

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Guidelines  22 results

ACR Appropriateness Criteria® Staging of Colorectal Cancer: 2021 Update.
https://doi.org/10.1016/j.jacr.2022.02.012
Journal of the American College of Radiology : JACR; , Korngold EK et. al.

May 14th, 2022 - Preoperative imaging of rectal carcinoma involves accurate assessment of the primary tumor as well as distant metastatic disease. Preoperative imaging of nonrectal colon cancer is most beneficial in identifying distant metastases, regardless of pr...

An Evidence-Based Guideline for Surveillance of Patients after Curative Treatment for C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870404
Current Oncology (Toronto, Ont.); Kennedy E, Zwaal C et. al.

Feb 25th, 2022 - To provide recommendations for a surveillance regimen that leads to the largest overall survival benefit for patients after curative treatment for Stage I-IV colon and rectal cancer. Consistent with the Program in Evidence-Based Care's standard ap...

Structured and shared MRI staging lexicon and report of rectal cancer: A consensus prop...
https://doi.org/10.1016/j.diii.2021.08.003
Diagnostic and Interventional Imaging; Nougaret S, Rousset P et. al.

Nov 20th, 2021 - To develop French guidelines by experts to standardize data acquisition, image interpretation, and reporting in rectal cancer staging with magnetic resonance imaging (MRI). Evidence-based data and opinions of experts of GRERCAR (Groupe de REcherch...

Multidisciplinary management of elderly patients with rectal cancer: recommendations fr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254305
World Journal of Emergency Surgery : WJES; Podda M, Sylla P et. al.

Jul 4th, 2021 - Although rectal cancer is predominantly a disease of older patients, current guidelines do not incorporate optimal treatment recommendations for the elderly and address only partially the associated specific challenges encountered in this populati...

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the ...
https://doi.org/10.1097/DCR.0000000000001984
Diseases of the Colon and Rectum; Hardiman KM, Felder SI et. al.

Feb 17th, 2021 - The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surveillance and Survivorship Care of Patients After Curative Treatment of Colon and Rectal Cancer.|2021|Hardiman KM,Felder SI,Friedman G,Migaly J,Paquette IM,|...

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Clinicaltrials.gov  363 results

Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer
https://clinicaltrials.gov/ct2/show/NCT04406857

May 13th, 2022 - PRIMARY OBJECTIVES: I. To determine the maximum tolerated dose (MTD) of oral (PO) ropidoxuridine (IPdR) when administered with capecitabine (825 mg/m^2 twice daily [BID]) and radiation therapy (RT) (50.4 Gy in 28 fractions). II. To determine the t...

Establishment of MRI Model for pTRG in Rectal Cancer With Establishment of
https://clinicaltrials.gov/ct2/show/NCT05374044

May 13th, 2022 - The study included two part: one is a retrospective single-center cohort for analyzing quantitative MRI factors associated with pTRG, from which a new MRI-based tumor response regression(mrTRG) classification method will be established. The other ...

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer
https://clinicaltrials.gov/ct2/show/NCT05009069

May 13th, 2022 - This study will evaluate the efficacy and safety of atezolizumab plus tiragolumab or atezolizumab alone following neoadjuvant chemoradiotherapy (nCRT) in participants with locally advanced rectal cancer (LARC). The study consists of a safety run-i...

Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal Cancer for a COLOMATE Trial
https://clinicaltrials.gov/ct2/show/NCT03765736

May 11th, 2022 - PRIMARY OBJECTIVES: I. To perform blood-based genomic profiling on patients with treatment refractory metastatic colorectal cancer (CRC) to facilitate accrual to molecularly assigned therapies. II. To facilitate clinically annotated genomic analys...

Multi-omics Model Predicts Efficacy of Preoperative Neoadjuvant Chemoradiotherapy Combined PD-1 Antibody Therapy for Locally Advanced Rectal Cancer
https://clinicaltrials.gov/ct2/show/NCT05368051

May 10th, 2022 - The purpose of this clinical research is to establish a multi-omics model based on genomics,transcriptomics,gut microbiota in predicting pathologic response after neoadjuvant chemoradiotherapy combined PD-1 antibody given to patients with locall...

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News  340 results

Adverse Events in IO-IO Combination Treatment Regimens for Advanced RCC
https://www.onclive.com/view/adverse-events-in-io-io-combination-treatment-regimens-for-advanced-rcc

May 2nd, 2022 - Arnab Basu, MD: In your experience, what are some of the commonly observed adverse events in this IO [immunotherapy]/IO combination therapy regimen, and how do you manage those? Shawnta Anakwah, MD: Typically, the ones that I’ve seen have been ra...

Total Neoadjuvant Chemotherapy Generates Comparable Efficacy to Chemoradiotherapy in Locally Advanced Rectal Cancer
https://www.onclive.com/view/total-neoadjuvant-chemotherapy-generates-comparable-efficacy-to-chemoradiotherapy-in-locally-advanced-rectal-cancer

Apr 22nd, 2022 - Short-term radiotherapy followed by total neoadjuvant chemotherapy (TNT) was found to be noninferior to long-term chemoradiotherapy (CRT) in patients with locally advanced rectal cancer, according to findings from the phase 3 STELLAR study (NCT025...

How Many Randomized Trials Does It Take to Make You Do the Right Thing?
https://www.medscape.com/viewarticle/971010

Mar 29th, 2022 - There are shops out there still performing only long-course radiotherapy for rectal cancer. One has to suspect that in talking to patients they are not bringing up the short-course option, or at least not in any way that fairly explains the extens...

Updated Results of CIRCULATE-Japan in Colorectal Cancer
https://www.onclive.com/view/updated-results-of-circulate-japan-in-colorectal-cancer

Feb 22nd, 2022 - Blase Polite, MD: I want to discuss the CIRCULATE-Japan program. It’s a somewhat complex design, so I’ll briefly describe the overall design of the trial and then focus on the GALAXY study. CIRCULATE-Japan is a 3-arm study of patients with stage I...

Gum Disease Linked to Colorectal Cancer: COLDENT Study
https://www.medscape.com/viewarticle/968247

Feb 10th, 2022 - Periodontal disease (PD) may increase the risk of sporadic colorectal cancer (CRC), findings from the population-based case-control COLDENT study suggest. The rate of new CRC diagnoses among individuals in the study who had a history of PD was nea...

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Patient Education  17 results see all →