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About 125,824 results

ALLMedicine™ Melanoma Center

Research & Reviews  58,681 results

Does biomarker use in oncology improve clinical trial failure risk? A large-scale analy...
https://doi.org/10.1002/cam4.3732
Cancer Medicine; Parker JL, Kuzulugil SS et. al.

Feb 23rd, 2021 - To date there has not been an extensive analysis of the outcomes of biomarker use in oncology. Data were pooled across four indications in oncology drawing upon trial outcomes from www.clinicaltrials.gov: breast cancer, non-small cell lung cancer ...

A MyD88/IL-1R axis regulates PD-1 expression on tumor-associated macrophages and sustai...
https://doi.org/10.1158/0008-5472.CAN-20-3510
Cancer Research; Tartey S, Neale G et. al.

Feb 23rd, 2021 - Macrophages are critical mediators of tissue homeostasis, cell proliferation, and tumor metastasis. Tumor-associated macrophages (TAMs) are generally associated with tumor-promoting immunosuppressive functions in solid tumors. Here we examined the...

The Adolescent and Young Adult (AYA) Horizon Study: An AYA cancer survivorship cohort.
https://doi.org/10.1158/1055-9965.EPI-20-1315
Cancer Epidemiology, Biomarkers & Prevention : a Publicat... Nichols HB, Baggett CD et. al.

Feb 23rd, 2021 - In the United States (U.S.), >45,000 adolescent and young adult (AYA) women are diagnosed with cancer annually. Reproductive issues are critically important to AYA cancer survivors, but insufficient information is available to address their concer...

Network models of primary melanoma microenvironments identify key melanoma regulators u...
https://doi.org/10.1038/s41467-021-21457-0 10.1016/j.cell.2015.05.044 10.1126/science.1253735 10.1038/labinvest.2016.142 10.1016/j.humpath.2006.01.003 10.1038/s41392-020-0134-x 10.1007/s00109-016-1415-2 10.1016/j.cell.2017.06.016 10.1586/erm.10.81 10.1080/15384047.2017.1323596 10.1007/s00018-017-2686-7 10.1002/cncr.24909 10.1007/s10434-999-0604-4 10.1038/nmeth.3337 10.1038/ncomms3612 10.1038/35019019 10.1038/nrg1272 10.1038/nrg2085 10.1038/nature06757 10.1038/nature06758 10.1126/science.1081900 10.1073/pnas.0605457103 10.1038/415141a 10.1073/pnas.0608396103 10.1038/35036627 10.1126/science.1099511 10.1038/nature08454 10.1038/ng1589 10.1371/journal.pbio.0060107 10.1126/science.1087447 10.1186/1752-0509-5-121 10.1101/gr.087890.108 10.1038/msb.2012.24 10.1101/gr.103341.109 10.2202/1544-6115.1128 10.1371/journal.pbio.1001301 10.1038/ng.167 10.1038/nature20123 10.1016/j.cell.2013.03.030 10.1016/j.envint.2019.04.052 10.18632/oncotarget.11870 10.1126/science.aad0095 10.1016/j.cell.2018.09.006 10.1371/journal.pcbi.1004574 10.1016/j.celrep.2017.04.031 10.1038/nm.2232 10.1038/ni.3205 10.1186/s12974-018-1330-2 10.1016/j.immuni.2018.03.023 10.3389/fimmu.2018.03118 10.1038/ncomms12846 10.1074/jbc.M103967200 10.1101/gr.473902 10.1091/mbc.8.10.2017 10.1083/jcb.145.6.1145 10.1093/hmg/ddn054 10.1007/BF02369916 10.1038/sj.onc.1210700 10.1038/sdata.2014.35 10.1093/nar/gku1003 10.1007/s00005-015-0382-6 10.1038/s41592-019-0355-5 10.1038/cddis.2017.67 10.18632/oncotarget.23580 10.3389/fphar.2019.00139 10.1158/1078-0432.CCR-14-3073 10.1074/jbc.M307969200 10.1158/0008-5472.CAN-07-1357 10.1016/j.bbrc.2014.07.070 10.1103/PhysRevE.85.046115 10.1016/j.dam.2011.07.018 10.1073/pnas.0500298102 10.1073/pnas.0601602103 10.1103/PhysRevE.85.046115 10.1126/science.1262110 10.1007/11569596_31 10.1038/s41467-017-02289-3 10.1155/2015/816460 10.1182/blood-2007-02-072587
Nature Communications; Song WM, Agrawal P et. al.

Feb 23rd, 2021 - Melanoma is the most lethal skin malignancy, driven by genetic and epigenetic alterations in the complex tumour microenvironment. While large-scale molecular profiling of melanoma has identified molecular signatures associated with melanoma progre...

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Guidelines  181 results

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice r...
https://doi.org/10.1007/s00520-020-05709-1
Supportive Care in Cancer : Official Journal of the Multi... Cooksley T, Girotra M et. al.

Aug 28th, 2020 - Immune checkpoint inhibitors (ICIs) have emerged as the newest pillar of cancer treatment, transforming outcomes in melanoma and showing benefit in a range of malignancies. Immune-mediated toxicities, stemming from increased activity within the T ...

ESMO consensus conference recommendations on the management of metastatic melanoma: und...
https://doi.org/10.1016/j.annonc.2020.07.004
Annals of Oncology : Official Journal of the European Soc... Keilholz U, Ascierto PA et. al.

Aug 8th, 2020 - The European Society for Medical Oncology (ESMO) held a consensus conference on melanoma on 5-7 September 2019 in Amsterdam, The Netherlands. The conference included a multidisciplinary panel of 32 leading experts in the management of melanoma. Th...

ESMO consensus conference recommendations on the management of locoregional melanoma: u...
https://doi.org/10.1016/j.annonc.2020.07.005
Annals of Oncology : Official Journal of the European Soc... Michielin O, van Akkooi A et. al.

Aug 8th, 2020 - The European Society for Medical Oncology (ESMO) held a consensus conference on melanoma on 5-7 September 2019 in Amsterdam, The Netherlands. The conference included a multidisciplinary panel of 32 leading experts in the management of melanoma. Th...

ASCO20 Virtual Scientific Program Showcases the Latest Advances in Melanoma Research
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200224/full/
ASCO Daily News;

Jun 24th, 2020 - The ASCO20 Virtual Scientific Program featured a range of studies showcasing the latest advances and clinical breakthroughs in melanoma research.

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Drugs  61 results see all →

Clinicaltrials.gov  62,603 results

Does biomarker use in oncology improve clinical trial failure risk? A large-scale analy...
https://doi.org/10.1002/cam4.3732
Cancer Medicine; Parker JL, Kuzulugil SS et. al.

Feb 23rd, 2021 - To date there has not been an extensive analysis of the outcomes of biomarker use in oncology. Data were pooled across four indications in oncology drawing upon trial outcomes from www.clinicaltrials.gov: breast cancer, non-small cell lung cancer ...

A MyD88/IL-1R axis regulates PD-1 expression on tumor-associated macrophages and sustai...
https://doi.org/10.1158/0008-5472.CAN-20-3510
Cancer Research; Tartey S, Neale G et. al.

Feb 23rd, 2021 - Macrophages are critical mediators of tissue homeostasis, cell proliferation, and tumor metastasis. Tumor-associated macrophages (TAMs) are generally associated with tumor-promoting immunosuppressive functions in solid tumors. Here we examined the...

The Adolescent and Young Adult (AYA) Horizon Study: An AYA cancer survivorship cohort.
https://doi.org/10.1158/1055-9965.EPI-20-1315
Cancer Epidemiology, Biomarkers & Prevention : a Publicat... Nichols HB, Baggett CD et. al.

Feb 23rd, 2021 - In the United States (U.S.), >45,000 adolescent and young adult (AYA) women are diagnosed with cancer annually. Reproductive issues are critically important to AYA cancer survivors, but insufficient information is available to address their concer...

Network models of primary melanoma microenvironments identify key melanoma regulators u...
https://doi.org/10.1038/s41467-021-21457-0 10.1016/j.cell.2015.05.044 10.1126/science.1253735 10.1038/labinvest.2016.142 10.1016/j.humpath.2006.01.003 10.1038/s41392-020-0134-x 10.1007/s00109-016-1415-2 10.1016/j.cell.2017.06.016 10.1586/erm.10.81 10.1080/15384047.2017.1323596 10.1007/s00018-017-2686-7 10.1002/cncr.24909 10.1007/s10434-999-0604-4 10.1038/nmeth.3337 10.1038/ncomms3612 10.1038/35019019 10.1038/nrg1272 10.1038/nrg2085 10.1038/nature06757 10.1038/nature06758 10.1126/science.1081900 10.1073/pnas.0605457103 10.1038/415141a 10.1073/pnas.0608396103 10.1038/35036627 10.1126/science.1099511 10.1038/nature08454 10.1038/ng1589 10.1371/journal.pbio.0060107 10.1126/science.1087447 10.1186/1752-0509-5-121 10.1101/gr.087890.108 10.1038/msb.2012.24 10.1101/gr.103341.109 10.2202/1544-6115.1128 10.1371/journal.pbio.1001301 10.1038/ng.167 10.1038/nature20123 10.1016/j.cell.2013.03.030 10.1016/j.envint.2019.04.052 10.18632/oncotarget.11870 10.1126/science.aad0095 10.1016/j.cell.2018.09.006 10.1371/journal.pcbi.1004574 10.1016/j.celrep.2017.04.031 10.1038/nm.2232 10.1038/ni.3205 10.1186/s12974-018-1330-2 10.1016/j.immuni.2018.03.023 10.3389/fimmu.2018.03118 10.1038/ncomms12846 10.1074/jbc.M103967200 10.1101/gr.473902 10.1091/mbc.8.10.2017 10.1083/jcb.145.6.1145 10.1093/hmg/ddn054 10.1007/BF02369916 10.1038/sj.onc.1210700 10.1038/sdata.2014.35 10.1093/nar/gku1003 10.1007/s00005-015-0382-6 10.1038/s41592-019-0355-5 10.1038/cddis.2017.67 10.18632/oncotarget.23580 10.3389/fphar.2019.00139 10.1158/1078-0432.CCR-14-3073 10.1074/jbc.M307969200 10.1158/0008-5472.CAN-07-1357 10.1016/j.bbrc.2014.07.070 10.1103/PhysRevE.85.046115 10.1016/j.dam.2011.07.018 10.1073/pnas.0500298102 10.1073/pnas.0601602103 10.1103/PhysRevE.85.046115 10.1126/science.1262110 10.1007/11569596_31 10.1038/s41467-017-02289-3 10.1155/2015/816460 10.1182/blood-2007-02-072587
Nature Communications; Song WM, Agrawal P et. al.

Feb 23rd, 2021 - Melanoma is the most lethal skin malignancy, driven by genetic and epigenetic alterations in the complex tumour microenvironment. While large-scale molecular profiling of melanoma has identified molecular signatures associated with melanoma progre...

see more →

News  4,201 results

Checkpoint Inhibitor Safety in Preexisting Autoimmune Diseases
https://www.medscape.com/viewarticle/945979

Feb 16th, 2021 - Patients with advanced melanoma and preexisting autoimmune diseases (AIDs) who were treated with immune checkpoint inhibitors (ICIs) responded well and did not suffer more grade 3 or higher immune-related adverse events than patients without an AI...

Personal Neoantigen Vaccine Prompts Lasting Response in Melanoma Patients
https://www.medscape.com/viewarticle/945370

Feb 7th, 2021 - NEW YORK (Reuters Health) - A small number of high-risk melanoma patients have continued to show durable CD4+ and CD8+ T cell responses against the majority of immunizing epitopes originally prompted by receipt of NeoVax, a vaccine targeting multi...

Fecal Transplant Overcomes Resistance to Immunotherapy
https://www.medscape.com/viewarticle/945346

Feb 4th, 2021 - Patients with advanced melanoma who had previously not responded to immunotherapy showed a response after treatment with fecal transplants. The material for the fecal transplants was obtained from patients who were experiencing a response to immun...

Expert Offers Tips for Sorting Out Pink Lesions on Dermoscopy
https://www.medscape.com/viewarticle/945115

Feb 1st, 2021 - Even in the most experienced hands, dermoscopy poses a challenge when the usual pigment clues are lacking to help distinguish melanoma from amelanotic melanoma and pigmented basal cell carcinoma (BCC) from nonpigmented BCC. Dr Jennifer Stein "For ...

Gene Test Helps Inform Management of High-Risk SCC Patients
https://www.medscape.com/viewarticle/945044

Jan 31st, 2021 - Emerging data support the clinical validity and use of DecisionDx-SCC as a prognostic 40-gene expression profile test for patients with high-risk squamous cell carcinoma (SCC), according to Anna A. Bar, MD. "The incidence of SCC has been growing r...

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Patient Education  97 results see all →