ALLMedicine™ Squamous Cell Carcinoma Center

Mar 20th, 2023 - Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) require multi-modality treatment. Immune checkpoint inhibitors (ICIs) are now standard of care in management of recurrent/metastatic HNSCC. However, its role in the defin...

Mar 19th, 2023 - Bromodomain-containing protein 4 (BRD4) is a reader of histone acetylation and is associated with a variety of diseases. To investigate the expression level of BRD4 in esophageal squamous cell carcinoma (ESCC), its prognostic value and its relatio...

Mar 19th, 2023 - Histone methylations are generally considered to play an important role in multiple cancers by regulating cancer-related genes. This study aims to investigate the effects of H3K27me3-mediated inactivation of tumor suppressor gene SFRP1 and its fun...

Mar 18th, 2023 - Optically clear cytoplasm may occur in neoplastic and non-neoplastic conditions, either as a characteristic feature of a disease entity or as a morphologic rarity, potentially creating diagnostic dilemmas in various organ systems. In the head and ...

Mar 18th, 2023 - Robot-assisted thoracic surgery (RATS) for higher stages non-small cell lung carcinoma (NSCLC) remains controversial. This study reports the feasibility of RATS in patients with stages IIB-IVA NSCLC. A single-institute, retrospective study was con...

Dec 16th, 2022 - To provide evidence-based recommendations for practicing physicians and other health care providers on immunotherapy and biomarker testing for head and neck cancers. ASCO convened an Expert Panel of medical oncology, surgical oncology, radiation o...

Jun 19th, 2022 - Previous anal cancer guidelines delineate target volumes similarly for all patients with squamous cell carcinoma of the anal canal and/or perianal skin (SCCA), regardless of disease stage. The purpose of this guideline is to provide customized rad...

Nov 30th, 2021 - Penile mucosal melanoma is an aggressive and rare genital malignancy. The aim of the present study was to review the management and outcomes of a homogenous cohort of patients with histologically confirmed penile mucosal melanoma, at a single spec...

Sep 18th, 2021 - We sought to compare the prognostic impact of tumor differentiation with respect to adverse risk factors (RFs) identified by the National Comprehensive Cancer Network (NCCN) guidelines--including extranodal extension (ENE), positive/close margins,...

May 8th, 2021 - Vulvar cancer is an uncommon gynecologic tumor and one of several human papillomavirus-associated malignancies. Squamous cell carcinoma is the most prevalent histologic subtype of vulvar cancer, accounting for the majority of cases. Imaging plays ...

Mar 10th, 2023 - Study Description: Individuals undergoing cisplatin-based chemoradiation therapy are at risk for developing significant, permanent hearing loss. The cholesterol-lowering drug atorvastatin has the potential to reduce the incidence and severity of h...

Mar 10th, 2023 - This Phase 0 study is a 3-arm window trial, randomizing patients to pre-operative treatment with 5-azacytidine alone, to nivolumab alone, or the combination of 5-azacytidine and nivolumab. The primary endpoint is immune-related pathologic response...

Mar 10th, 2023 - PRIMARY OBJECTIVES: I. To evaluate overall survival (OS) of adjuvant reirradiation plus concurrent pembrolizumab followed by pembrolizumab to complete 12 months total of pembrolizumab to adjuvant reirradiation plus concurrent platinum chemotherapy...

Mar 10th, 2023 - OBJECTIVES: Primary Determine the feasibility of adjuvant low-dose capecitabine in patients with squamous cell carcinoma of the head and neck who have undergone prior curative surgery, radiotherapy, and/or chemotherapy. Secondary Determine the tim...

Mar 10th, 2023 - PRIMARY OBJECTIVES: I. To evaluate the disease-free survival (DFS) of patients with stage III-IV squamous cell carcinoma of the head and neck (SCCHN) and disruptive p53 mutations after primary surgical resection followed by postoperative radiother...

Mar 9th, 2023 - How the successful use of pembrolizumab (Keytruda) for former President Jimmy Carter's metastatic melanoma put "immunotherapy on the map." (Washington Post) A study of molecular changes observed in the breast tissue of transgender men undergoing a...

Mar 2nd, 2023 - Verrucous carcinoma (VC) is an uncommon type of well-differentiated squamous cell carcinoma (SCC) that most commonly affects men in the fifth to sixth decades of life. 1 The tumor grows slowly over a decade or more and does not frequently metastas.

Feb 28th, 2023 - The history and findings in this case are suggestive of non–small cell lung cancer (NSCLC) large cell carcinoma. Lung cancer is the most common cancer worldwide and has the highest mortality rate of all cancers.

Feb 28th, 2023 - The history and findings in this case are suggestive of non–small cell lung cancer (NSCLC) large cell carcinoma. Lung cancer is the most common cancer worldwide and has the highest mortality rate of all cancers.

Feb 28th, 2023 - The history and findings in this case are suggestive of non–small cell lung cancer (NSCLC) large cell carcinoma. Lung cancer is the most common cancer worldwide and has the highest mortality rate of all cancers.