ALLMedicine™ Thyroid Cancer Center

Aug 16th, 2022 - Neutropenia related to ELANE gene mutations predisposes patients to infection and leukemia/myelodysplasia, but little is known about the predisposition to cancer. Among a cohort of 147 patients, we identified four with malignant solid tumors (papi...

Aug 16th, 2022 - Thyroid carcinoma (TC) is an increasingly common malignancy of endocrine organs, and its most frequently encountered histotype is papillary thyroid cancer (PTC). Identifying new potential gene alterations is important for completely elucidating th...

Aug 13th, 2022 - Oncogenic RET fusions occur in diverse cancers. Pralsetinib is a potent, selective inhibitor of RET receptor tyrosine kinase. ARROW ( NCT03037385 , ongoing) was designed to evaluate pralsetinib efficacy and safety in patients with advanced RET-alt...

Aug 13th, 2022 - Although papillary thyroid cancer (PTC) has a low mortality rate, the rate of recurrence remains relatively high. This study aims to develop a molecular signature to predict the recurrence of PTC. A total of 333 PTC patients' data from The Cancer ...

Aug 12th, 2022 - PRIMARY OBJECTIVE: I. To determine the maximum tolerated dose of lapatinib that can be used in combination of dabrafenib. SECONDARY OBJECTIVES: I. To observe and record anti-tumor activity. II. Evaluate potential mechanisms of primary resistance o...

May 2nd, 2022 - ESMO Clinical Practice Guideline update on the use of systemic therapy in advanced thyroid cancer.|2022|Filetti S,Durante C,Hartl DM,Leboulleux S,Locati LD,|drug therapy,

Apr 2nd, 2021 - Background: The American Thyroid Association (ATA), the European Association of Nuclear Medicine, the European Thyroid Association, and the Society of Nuclear Medicine and Molecular Imaging have established an intersocietal working group to addres...

Mar 18th, 2021 - Background: Anaplastic thyroid cancer (ATC) is a rare but highly lethal form of thyroid cancer. Since the guidelines for the management of ATC by the American Thyroid Association were first published in 2012, significant clinical and scientific ad...

Apr 10th, 2020 - The Japan Associations of Endocrine Surgeons has developed the revised version of the Clinical Practice Guidelines for Thyroid Tumors. This article describes the guidelines translated into English for the 35 clinical questions relevant to the ther...

Mar 8th, 2020 - International thyroid nodule and cancer management guidelines generally fail to take into account potential limitations in diagnostic and treatment resources. Thyroid cancer specialists from the African Head and Neck Society and American Head & Ne...

Aug 12th, 2022 - PRIMARY OBJECTIVE: I. To determine the feasibility of an intensive (systolic blood pressure [SBP] < 120 mmHg) "Intervention" versus standard care (SBP < 140 mmHg) "Non-Intervention" approach to blood pressure (BP) control in metastatic renal cell ...

Aug 12th, 2022 - PRIMARY OBJECTIVE: I. To determine the maximum tolerated dose of lapatinib that can be used in combination of dabrafenib. SECONDARY OBJECTIVES: I. To observe and record anti-tumor activity. II. Evaluate potential mechanisms of primary resistance o...

Aug 12th, 2022 - Clinical and subclinical thyroid disease is usually used to describe patients with mild symptoms correlated to hyperthyroid or hypothyroid state. Thyroid ultrasonography could differentiate benign or malignant nodular lesion, together with fine ne...

Aug 11th, 2022 - A study to evaluate the efficacy and safety of pralsetinib compared with SOC treatment (cabozantinib or vandetanib) for participants with RET (rearranged during transfection)-mutant MTC who have not previously received a SOC MultiKinase Inhibitor ...

Aug 9th, 2022 - Adaptive sample size re-estimation will be performed at interim analysis. The sample size could be increased from approximately 250 to 400 depending on the results of interim analysis.

Jul 21st, 2022 - A nursing student recently used a TikTok video that went viral to share how she believed that her Apple Watch could have helped diagnose her thyroid condition. Noting that such wearable devices can track oxygen levels, heart rate, presence of irre...

Jul 19th, 2022 - As many as 40% of thyroid nodule surgeries involve nodules that are asymptomatic. These nodules are often detected by chance during imaging for other purposes, new research shows. Cancer was found only in 46% of these cases. "The results of this s...

Jul 7th, 2022 - This transcript has been edited for clarity. Angela Leung, MD, MSc: Welcome to this video commentary about the long-term use of antithyroid drugs in the management of Graves disease. My name is Angela Leung. I'm an adult endocrinologist at the Uni...

Jun 23rd, 2022 - The US Food and Drug Administration has granted accelerated approval to dabrafenib (Tafinlar) plus trametinib (Mekinist) for adult and pediatric patients aged 6 years and older with unresectable or metastatic solid tumors with the BRAF V600E mutat...

Jun 22nd, 2022 - Clinicians don't cease diagnosing patients once our clinical work is done. Most of us can recall debating whether to point out an atypical mole or another concerning finding to a stranger in public. Like the doctor back in 2018, who saw a lump on ...