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About 18,903 results

ALLMedicine™ Acute Lymphoblastic Leukemia Center

Research & Reviews  6,371 results

Newly proposed threshold and validation of white blood cell count at diagnosis for Phil...
https://doi.org/10.1038/s41409-021-01422-7 10.1182/blood-2003-08-2958 10.1182/blood-2013-11-538728 10.1016/j.bbmt.2019.07.037 10.1182/blood-2013-09-529008 10.1016/S2352-3026(18)30176-5 10.1182/blood-2015-02-627935 10.1182/bloodadvances.2016001495 10.1016/j.bbmt.2019.08.014 10.1016/j.bbmt.2017.12.777 10.1016/S0889-8588(05)70188-X 10.1182/blood.V71.1.123.123 10.1200/JCO.2010.30.1382 10.1038/bmt.2013.140 10.1038/bmt.2015.217 10.3324/haematol.2018.201053 10.1053/j.seminhematol.2020.06.003 10.3324/haematol.2014.116954 10.1016/j.bbmt.2011.08.011 10.1002/cncr.31874 10.1182/blood-2009-12-261586 10.1182/blood-2016-03-707562 10.1111/bjh.16540 10.1007/s12185-015-1894-x 10.1038/sj.leu.2402483 10.1007/s12185-021-03094-x 10.1016/j.bbmt.2018.06.006 10.1038/s41409-018-0218-1 10.1038/s41409-020-0951-0 10.1016/j.bbmt.2017.11.025 10.1186/s13045-019-0790-x 10.1200/JCO.2017.75.8177 10.1016/j.ejca.2018.11.003 10.1016/j.bbmt.2009.02.007 10.1200/JCO.19.00396 10.1182/blood-2010-02-266551 10.1016/j.bbmt.2008.12.497 10.1038/bmt.2012.244 10.1002/cncr.30130 10.1111/cas.14167 10.1200/JCO.2008.21.6408 10.3324/haematol.2018.196055 10.1182/blood-2017-07-796862 10.1182/blood-2006-11-052373 10.3324/haematol.2010.034173 10.1016/j.exphem.2020.01.001 10.1002/cncr.28522 10.1182/blood-2016-02-700153 10.1007/s00277-020-04212-1 10.1182/blood-2016-09-739086 10.1056/NEJMoa1609783 10.1182/bloodadvances.2019000457 10.1056/NEJMoa1509277 10.1056/NEJMoa1709866 10.1016/j.bbmt.2019.04.020 10.7326/M14-0698
Bone Marrow Transplantation; Akahoshi Y, Arai Y et. al.

Aug 1st, 2021 - White blood cell count (WBC) at diagnosis is the conventional prognostic factor in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Nevertheless, little is known about the impact of WBC at diagnosis considering the minimal ...

Reducing sedated lumbar punctures in pediatric patients with acute lymphoblastic leukemia.
https://doi.org/10.1002/pbc.29272
Pediatric Blood & Cancer; Waters TW, Dickens DS

Aug 1st, 2021 - Sedation for lumbar punctures (LPs) in pediatric acute lymphoblastic leukemia (ALL) patients has been the standard for decades to reduce pain and anxiety. Recent studies on the potential long-term neurocognitive effects of cumulative propofol expo...

Treatment-induced cerebral sinus venous thrombosis in childhood acute lymphoblastic mal...
https://doi.org/10.1002/pbc.29210
Pediatric Blood & Cancer; El-Khoury H, Saifi O et. al.

Jul 31st, 2021 - Cerebral sinus venous thrombosis (CSVT) is one of the many side effects encountered during acute lymphoblastic leukemia (ALL) therapy. Due to the rarity of cases, lack of data, and consensus management, no recommendations exist to target the popul...

Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leuk...
https://doi.org/10.1200/JCO.21.00389
Journal of Clinical Oncology : Official Journal of the Am... Pan J, Tan Y et. al.

Jul 30th, 2021 - Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (r/r T-ALL) have few options and poor prognosis. The aim was to assess donor-derived anti-CD7 chimeric antigen receptor (CAR) T-cell safety and efficacy in patients with r/r ...

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Guidelines  3 results

Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelin...
https://doi.org/10.6004/jnccn.2020.0001
Journal of the National Comprehensive Cancer Network : JN... Brown P, Inaba H et. al.

Jan 8th, 2020 - Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Advancements in technology that enhance our understanding of the biology of the disease, risk-adapted therapy, and enhanced supportive care have contributed to improved su...

NCCN Guidelines Insights: Acute Lymphoblastic Leukemia, Version 1.2017.
https://doi.org/10.6004/jnccn.2017.0147
Journal of the National Comprehensive Cancer Network : JN... Brown PA, Shah B et. al.

Sep 7th, 2017 - The prognosis for patients with newly diagnosed acute lymphoblastic leukemia (ALL) has improved with the use of more intensive chemotherapy regimens, tyrosine kinase inhibitors, targeted agents, and allogeneic hematopoietic cell transplantation. H...

Role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment...
https://doi.org/10.1016/j.bbmt.2011.12.585
Biology of Blood and Marrow Transplantation : Journal of ... Oliansky DM, Camitta B et. al.

Jan 3rd, 2012 - Clinical research published since the first evidence-based review on the role of hematopoietic stem cell transplantation (SCT) in the treatment of pediatric acute lymphoblastic leukemia (ALL) is presented and critically evaluated in this update. T...

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Drugs  109 results see all →

Clinicaltrials.gov  386 results

A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients
https://clinicaltrials.gov/ct2/show/NCT03677596

May 7th, 2020 - This study will explore 2 different doses of inotuzumab ozogamicin including the dose that is approved and a lower dose. The main purpose of this study is to evaluate whether a dose of inotuzumab ozogamicin, lower than the approved dose, could be ...

Study Evaluating the Efficacy and Safety of JCAR015 in Adult B-cell Acute Lymphoblastic Leukemia (B-ALL)
https://clinicaltrials.gov/ct2/show/NCT02535364

May 4th, 2020 - This is a single-arm, multicenter Phase 2 study to determine the efficacy and safety of JCAR015 in adult patients with relapsed or refractory B-ALL. The study will have the following sequential phases: Part A (screening, leukapheresis, cell produc...

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome
https://clinicaltrials.gov/ct2/show/NCT03670966

May 1st, 2020 - OUTLINE: This is a dose-escalation study of astatine At 211 anti-CD45 monoclonal antibody BC8-B10. PREPARATIVE REGIMEN: Patients receive astatine At 211 anti-CD45 monoclonal antibody BC8-B10 infusion on day -8, fludarabine intravenously (IV) over ...

Augmentation of the Graft vs. Leukemia Effect Via Checkpoint Blockade With Pembrolizumab
https://clinicaltrials.gov/ct2/show/NCT03286114

Apr 28th, 2020 - This is a single arm, open-label, Phase 1b study of pembrolizumab for patients with myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL) whose disease has relapsed after receiving allogeneic hematopo...

Cancer Care Delivery in Adolescent and Young Adult Patients With Acute Lymphoblastic Leukemia
https://clinicaltrials.gov/ct2/show/NCT03204916

Apr 27th, 2020 - PRIMARY OBJECTIVES: I. To evaluate the proportion of adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) patients with a documented treatment plan consistent with NCCN guidelines for AYAs with ALL. II. To evaluate the proportion of...

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News  689 results

FDA Approves New Asparaginase Product for Leukemia
https://www.medscape.com/viewarticle/954149

Jul 2nd, 2021 - The US Food and Drug Administration (FDA) has approved a new version of asparaginase for use in children and adults who have developed hypersensitivity to asparaginase derived from Escherichia coli. The new product is Jazz Pharmaceutical's Rylaze ...

Venetoclax Shows Activity Against T-ALL in Children
https://www.medscape.com/viewarticle/952355

Jun 3rd, 2021 - Data from a small retrospective study suggest that venetoclax-based regimens may have activity against relapsed or refractory T-lineage acute lymphoblastic leukemia (T-ALL) in children and young adults. Among seven patients with T-ALL treated with...

Sex Differences in Pediatric B-ALL Outcomes Persist
https://www.medscape.com/viewarticle/951639

May 21st, 2021 - Even in the age of intensive therapy and extensive risk stratification, there are small but significant differences in outcomes between boys and girls with B-lineage acute lymphoblastic leukemia (B-ALL). This finding comes from a review of 10 year...

Low-Calorie Diet Linked to Improved Chemo Response in Leukemia
https://www.medscape.com/viewarticle/948896

Apr 7th, 2021 - Children and adolescents with leukemia who were placed on a restrictive diet and exercise regimen concurrent with starting chemotherapy showed responses to treatment that were better than those historically seen in such patients. This apparently i...

Allo-HSCT Plus MAb Can Boost Survival in Patients With r/r B-ALL
https://www.medscape.com/viewarticle/948153

Mar 25th, 2021 - The use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) can improve survival in minimal residual disease (MRD)-negative remission patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL) after the start...

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Patient Education  3 results see all →