×
About 403 results

ALLMedicine™ Myeloproliferative Disease Center

Research & Reviews  148 results

Salsalate, Venetoclax, and Decitabine or Azacitidine for the Treatment of Acute Myeloid Leukemia or Advanced Myelodysplasia/Myeloproliferative Disease
https://clinicaltrials.gov/ct2/show/NCT04146038

May 17th, 2022 - PRIMARY OBJECTIVE: I. Determine the tolerability of the addition of standard dose salsalate to the standard treatment combination of venetoclax + hypomethylating agent (HMA) (decitabine or azacitidine [5-azacytidine]). SECONDARY OBJECTIVES: I. Det...

Pernicious Anemia Differential Diagnoses
https://emedicine.medscape.com/article/204930-differential

May 16th, 2022 - Diagnostic Considerations By definition, pernicious anemia refers specifically to vitamin B12 deficiency resulting from a lack of production of intrinsic factor (IF) in the stomach. However, vitamin B12 absorption is a complex process, and other c...

IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driv...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670266
Molecular Cancer; Cai B, Liu Y et. al.

Dec 16th, 2021 - Stem Cell leukemia/lymphoma syndrome (SCLL) presents as a myeloproliferative disease which can progress to acute myeloid leukemia and is associated with the coincident development of B-cell and T-cell lymphomas. SCLL is driven by the constitutive ...

A Case of Thrombotic Vasculopathy in the Setting of High-Dose Hydroxyurea Use.
https://www.ncbi.nlm.nih.gov/pubmed/34882096
Wounds : a Compendium of Clinical Research and Practice; Michalak J, Simman R et. al.

Dec 10th, 2021 - This case study describes the presentation of a 76-year-old male with a past medical history that included atrial fibrillation, essential hypertension, coronary artery disease status post cardiac stent placement, heart failure, hyperlipidemia, thy...

Guideline for management of non-Down syndrome neonates with a myeloproliferative diseas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883540
Haematologica Bertrums EJM, Zwaan CM et. al.

Dec 3rd, 2021 - Guideline for management of non-Down syndrome neonates with a myeloproliferative disease on behalf of the I-BFM AML Study Group and EWOG-MDS.|2021|Bertrums EJM,Zwaan CM,Hasegawa D,De Haas V,Reinhardt DN,|complications,diagnosis,therapy,complicatio...

see more →

Guidelines  1 results

Prophylaxis and management of venous thromboembolism in patients with myeloproliferativ...
https://doi.org/10.1007/s00277-014-2224-8
Annals of Hematology; Kreher S, Ochsenreither S et. al.

Oct 14th, 2014 - Patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) like polycythemia vera and essential thrombocythemia are at increased risk of arterial and venous thrombosis. Strategies of prevention may consist of platelet aggreg...

see more →

Clinicaltrials.gov  6 results

Salsalate, Venetoclax, and Decitabine or Azacitidine for the Treatment of Acute Myeloid Leukemia or Advanced Myelodysplasia/Myeloproliferative Disease
https://clinicaltrials.gov/ct2/show/NCT04146038

May 17th, 2022 - PRIMARY OBJECTIVE: I. Determine the tolerability of the addition of standard dose salsalate to the standard treatment combination of venetoclax + hypomethylating agent (HMA) (decitabine or azacitidine [5-azacytidine]). SECONDARY OBJECTIVES: I. Det...

Observational Study Towards the Impact of Newly Started Treatment in MDS on QoL
https://clinicaltrials.gov/ct2/show/NCT04053933

Aug 13th, 2019 - Study type An observational study conducted in different hematological centers in Belgium. Study objectives Primary objective: To assess the impact of newly started treatments on the QOL of patients suffering from myelodysplastic syndromes. Second...

Natural Killer Cells and Polycythemia Vera (Vaquez's Disease)
https://clinicaltrials.gov/ct2/show/NCT01284712

Oct 1st, 2015 - Natural Killer cells (NK) are pivotal cells of innate immunity, that sense defective expression of HLA class I molecules and are complementary to specific cytotoxic T lymphocytes. A defect in NK cell cytotoxicity has been described in some hematop...

CEP-701 (Lestaurtinib) in Myelofibrosis
https://clinicaltrials.gov/ct2/show/NCT00668421

Nov 26th, 2014 - Myelofibrosis is the gradual replacement of bone marrow (place where most new blood cells are produced) by fibrous tissue which reduces the body's ability to produce new blood cells and results in the development of chronic anemia (low red blood c...

INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease
https://clinicaltrials.gov/ct2/show/NCT01164163

Oct 23rd, 2014 - OBJECTIVES: Primary To estimate the maximum-tolerated dose and/or recommended phase II dose of oral JAK inhibitor INCB18424 administered continuously, twice daily to pediatric patients with relapsed or refractory solid tumors. To define and descri...

see more →

News  6 results

Breaking Down the Epidemiology of AML
https://www.onclive.com/view/breaking-down-the-epidemiology-of-aml

Apr 2nd, 2021 - Transcript: Richard F. Schlenk, MD: Acute myeloid leukemia [AML] is a hematological disease focused on myeloid cells. It’s characterized by different mutations, which occur in the hematopoietic stem cells but also the hematopoietic progenitor ...

Somatic Mutations Could Predict Response to Hypomethylating Agents in MDS
https://www.onclive.com/view/somatic-mutations-could-predict-response-to-hypomethylating-agents-in-mds

Dec 20th, 2020 - Aziz Nazha, MD A biomarker model that incorporates the mutational status of multiple somatic genes could be used to predict response to hypomethylating agents for patients with myelodysplastic syndromes (MDS), according to findings from a small p...

Switch may increase supply of HSCs from cord blood
https://www.mdedge.com/hematology-oncology/article/187211/transplantation/switch-may-increase-supply-hscs-cord-blood
HT Staff

Jul 15th, 2016 - Cord blood donation Photo courtesy of NHS Researchers have discovered a genetic switch that could increase the supply of hematopoietic stem cells (HSCs) derived from cord blood, according to a paper published in Cell Stem Cell. However, experiment.

A Simple, Rapid, and Sensitive Method for the Detection of the JAK2 V617F Mutation
https://www.medscape.com/viewarticle/558906_3

Results Optimization The important variables for the ACB-PCR assay to detect the V617F mutation were the annealing temperature, dNTP concentration, and primer concentration. The majority of the conditions were modeled from a previous ACB-PCR assay...

A Simple, Rapid, and Sensitive Method for the Detection of the JAK2 V617F Mutation
https://www.medscape.com/viewarticle/558906_1

Abstract and Introduction Abstract The point mutation 1849 (GAET) V617F in the JAK2gene occurs at high frequency in several chronic myeloproliferative diseases. Although a number of V617F mutation detection methods have been described, few are rea...

see more →