About 69,680 results

ALLMedicine™ Melanoma Center

Research & Reviews  23,220 results

Oncogenic properties via MAPK signaling of the SOX5-RAF1 fusion gene identified in a wi...
Pigment Cell & Melanoma Research; Vinyals A, Ferreres JR et. al.

May 20th, 2022 - We recently reported a RAF rearrangement without NRAS or BRAF mutations in lesions from Giant Congenital Melanocytic Nevi (CMN). The new gene fusion involves the 5' end of the promoter-containing N terminus of the SOX5 gene fused to exons 7-16 of ...

War Against NRAS-mutant Melanoma Using Targeted Therapies Remains Challenging.
Clinical Cancer Research : an Official Journal of the Ame... Moschos SJ

May 20th, 2022 - In search for targeting MAPK plus other pathways in NRAS-mutant melanoma, a phase Ib/II trial tested binimetinib plus ribociclib in metastatic melanoma. The response rate in the phase 2 trial was 19.5% and the median progression-free survival was ...

Curcumin Inhibits the Growth and Metastasis of Melanoma via miR-222-3p/SOX10/Notch Axis.
Disease Markers; Tang Y, Cao Y

May 20th, 2022 - The aim of this study was to investigate the effect of curcumin on melanoma and its mechanism. Curcumin (0, 0.125, 0.25, or 0.5 mg/ml) was utilized to treat A375 and HT144 cell lines. The MTT analysis was used to confirm the proliferation ability....

Trunk melanomas: no survival differences between lesion sites.
Postgraduate Medicine; Tas F, Erturk K

May 19th, 2022 - The anatomic site of primary melanoma is significantly associated with patient survival, e.g., trunk melanomas have poorer prognosis than limb melanomas. The aim of this study was to evaluate the clinicopathological factors and survival outcomes o...

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Guidelines  38 results

Clinical features, molecular characteristics and surgical management of primary penile ...
Melanoma Research; Cakir OO, Pozzi E et. al.

Nov 30th, 2021 - Penile mucosal melanoma is an aggressive and rare genital malignancy. The aim of the present study was to review the management and outcomes of a homogenous cohort of patients with histologically confirmed penile mucosal melanoma, at a single spec...

New Eye Cancer Therapy Shown to Target Cancer Cells, Spare Vision
American Academy of Ophthalmology

Nov 15th, 2021 - NEW ORLEANS, La. – Choroidal melanoma is a rare cancer that affects the back of the eye. If the tumor grows, it can cause the retina to detach, leading to vison loss. And if it spreads to other parts of the body, it can be fatal. There are no appr...

Management of Pyrexia Associated with the Combination of Dabrafenib and Trametinib: Can...
Current Oncology (Toronto, Ont.); Thawer A, Miller WH et. al.

Oct 1st, 2021 - The combination of dabrafenib and trametinib is a well-established treatment for BRAF-mutated melanoma. However, the effectiveness of this approach may be hindered by the development of treatment-related pyrexia syndrome, which occurs in at least ...

Annual Report to the Nation: Rapid Decrease in Lung Cancer and Melanoma Deaths Lead Overall Continued Decline in Cancer Death Rate
American Cancer Society

Jul 8th, 2021 - Overall cancer death rates continue to decline in men and women for all racial and ethnic groups in the United States, according to the latest Annual Report to the Nation on the Status of Cancer. During 2001 to 2018, declines in lung cancer death ...

NCCN Guidelines® Insights: Melanoma: Cutaneous, Version 2.2021.
Journal of the National Comprehensive Cancer Network : JN... Swetter SM, Thompson JA et. al.

Apr 13th, 2021 - Over the past few years, the NCCN Guidelines for Melanoma: Cutaneous have been expanded to include pathways for treatment of microscopic satellitosis (added in v2.2020), and the following Principles sections: Molecular Testing (added in v2.2019), ...

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Drugs  50 results see all →

Clinicaltrials.gov  1,007 results

Multicenter Selective Lymphadenectomy Trial II (MSLT-II)

May 13th, 2022 - Subjects must be diagnosed with melanoma. All subjects receive sentinel lymphadenectomy. If the subject is sentinel node positive and meets study requirements, the subject is randomized to receive either (1) completion lymphadenectomy (2) observat...

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

May 13th, 2022 - Background: Metastatic digestive tract cancers, in particular esophageal, gastric, pancreatic and hepatobiliary carcinomas, are associated with poor survival beyond five years and poor response to existing therapies. Data from the National Cancer ...

Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).

May 13th, 2022 - Background: Among the new cases of bile tract carcinoma (BTC) that are diagnosed every year in the United States, there are approximately 6,500 cases of gallbladder carcinoma, 3,000 cases of extrahepatic cholangiocarcinoma, and 3,000 cases of intr...

M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung Cancers

May 13th, 2022 - Background Small cell lung cancer (SCLC) is an aggressive cancer with a poor prognosis. Although highly responsive to chemotherapy initially, SCLC relapses quickly and becomes refractory to treatment within a few months. Extrapulmonary small cell ...

Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

May 13th, 2022 - Background: Rare tumors are defined as fewer than 150 incident cases per one million per year. Consequently, only 11 tumor types are common in U.S. adults (prostate, breast, lung/bronchus, colon, uterus, bladder, melanoma, rectum, ovary, non-Hodgk...

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News  3,524 results

Experts Urge Stopping Melanoma Trial Because of Failure and Harm

May 19th, 2022 - New results from a phase 3 clinical trial may shut the door on the addition of progressive death–1 or PD–ligand 1 inhibitors to the combination of BRAF and MEK inhibitors for the treatment of BRAF V600–mutated melanoma. The approach seemed promisi...

Study Hints at a Mechanism Behind Aggressive Melanoma

May 11th, 2022 - A mutation in a gene involved in chromatin remodeling is associated with aggressive melanoma, according to a new study that combined in vitro and animal model data. The gene, ARID2, is a part of the switch/sucrose nonfermentable (SWI/SNF) complex,...

Study hints at a mechanism behind aggressive melanoma
Jim Kling

May 9th, 2022 - A mutation in a gene involved in chromatin remodeling is associated with aggressive melanoma, according to a new study that combined in vitro and animal model data. The gene, ARID2, is a part of the switch/sucrose nonfermentable (SWI/SNF) complex,.

Substantial Medical Debt, Bankruptcy Linked to Thyroid Cancer

May 9th, 2022 - Patients with thyroid cancer may experience greater financial challenges compared to those with other common cancers, a recent review suggests. Researchers found, for instance, that patients with thyroid cancer had higher total yearly healthcare e...

Impact of the COVID-19 Pandemic on Characteristics of Cutaneous Tumors Treated by Mohs Micrographic Surgery
Julie A. Croley, MD, Paige Hoyer, MD et. al.

May 6th, 2022 - The COVID-19 pandemic has brought about unprecedented changes and challenges to medical practice, including new public health measure legislation, local and national medical authority recommendations, nursing home and other ancillary health center.

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Patient Education  33 results see all →