×
About 8,158 results

ALLMedicine™ Medulloblastoma Center

Research & Reviews  4,017 results

Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.
https://doi.org/10.1038/s41388-021-01701-z 10.1101/gad.938601 10.1016/j.ccr.2008.07.003 10.3390/jdb4020020 10.1038/ijos.2015.14 10.1016/j.bone.2017.06.014 10.1038/nature01657 10.1101/gad.13.16.2072 10.1038/nrc3079 10.1200/JCO.2009.27.4324 10.1200/JCO.2005.04.4974 10.1158/1078-0432.CCR-13-1425 10.1056/NEJMoa0902903 10.1016/j.ccell.2015.02.002 10.1016/j.ccell.2015.02.001 10.1098/rsob.180098 10.1038/sj.onc.1210467 10.1016/j.ccr.2008.01.027 10.1093/neuonc/nox109 10.18632/oncotarget.20619 10.1038/343425a0 10.1002/(SICI)1096-8628(20000214)90:4<339::AID-AJMG15>3.0.CO;2-5 10.1038/9700 10.1126/science.7985023 10.1016/S0092-8674(01)00369-5 10.1016/j.cell.2016.08.003 10.7554/eLife.20304 10.1038/nature18934 10.1158/1078-0432.CCR-17-2923 10.1016/j.str.2018.11.003 10.1073/pnas.1717891115 10.1007/978-1-4939-7493-1_17 10.1093/nar/gkaa216 10.1093/bioinformatics/btaa102 10.1016/j.csbj.2015.09.001 10.1002/bit.20828 10.1111/j.1476-5381.2009.00430.x 10.1016/j.jacl.2014.02.010 10.1111/j.1476-5381.2011.01724.x 10.1242/dev.056499 10.1038/nn.2467 10.1093/hmg/ddv042 10.1242/dev.162396 10.3109/03602539009041088 10.1016/S0009-9236(98)90034-0 10.1016/S0009-9236(98)90130-8 10.1111/j.1472-8206.2004.00299.x 10.1016/j.jacl.2017.11.007 10.1001/jama.2014.8892 10.1038/s41413-019-0078-3 10.1073/pnas.0608449104 10.1038/s41413-018-0034-7 10.1093/hmg/ddg129 10.1074/jbc.M305518200 10.1001/jama.1962.03050300059020a 10.1093/jn/110.11.2310 10.1016/S0140-6736(00)02400-4 10.1210/en.2002-220682 10.1001/jama.283.24.3211 10.1126/science.286.5446.1946 10.1016/j.ccell.2017.05.005 10.1016/S1470-2045(17)30243-7 10.1038/s41568-019-0223-8 10.1038/nprot.2008.95
Oncogene Fan Q, Gong T et. al.

Mar 2nd, 2021 - The Hedgehog (Hh) pathway plays an indispensable role in bone development and genetic activation of the pathway results in medulloblastoma (MB), the most common malignant brain tumor in children. Inhibitors of Hh pathway (such as vismodegib and so...

Intramedullary metastasis in medulloblastoma: a case report and literature review.
https://doi.org/10.1007/s00381-021-05086-y 10.3109/02688697.2011.603855 10.3171/jns.1986.65.2.0253 10.3171/jns.1978.48.4.0632 10.1016/j.wneu.2018.06.250 10.1007/s00381-006-0167-7 10.1159/000377729 10.1016/j.wneu.2012.04.005 10.3171/2015.5.FOCUS15143 10.1016/j.wneu.2018.05.216 10.1007/s00401-011-0922-z
Child's Nervous System : ChNS : Official Journal of the I... Jiang H, Luo T et. al.

Feb 27th, 2021 - Cerebellar medulloblastomas are the most common malignant tumors of the posterior fossa in childhood that frequently metastasize. Leptomeningeal dissemination and distant metastasis have been associated with medulloblastomas; however, intramedulla...

Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/...
https://doi.org/10.1080/15384047.2021.1883186
Cancer Biology & Therapy; Yang D, Ma X et. al.

Feb 26th, 2021 - Emerging documents revealed that E2 enzyme family has been implicated in regulating the progression of numerous human cancers. Ubiquitin-conjugating enzyme E2 J1 (UBE2J1), a member of E2 enzyme family, has been reported to participate in the biolo...

Paracrine placental growth factor signaling in response to ionizing radiation is p53-de...
https://doi.org/10.1158/1541-7786.MCR-20-0403
Molecular Cancer Research : MCR; Kazimova T, Tschanz F et. al.

Feb 23rd, 2021 - Placental growth factor (PlGF) is a pro-angiogenic, N-glycosylated growth factor, which is secreted under pathological situations. Here, we investigated the regulation of PlGF in response to ionizing radiation (IR) and its role for tumor angiogene...

Molecular determinants of medulloblastoma metastasis and leptomeningeal dissemination.
https://doi.org/10.1158/1541-7786.MCR-20-1026
Molecular Cancer Research : MCR; Li M, Deng Y et. al.

Feb 20th, 2021 - Medulloblastoma (MB) is the most common malignant brain cancer in pediatrics consisting of four molecular subgroups, namely wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. One of the biggest challenges in the clinical management of thi...

see more →

Guidelines  1 results

SIOP PODC adapted treatment recommendations for standard-risk medulloblastoma in low an...
https://doi.org/10.1002/pbc.25313
Pediatric Blood & Cancer; Parkes J, Hendricks M et. al.

Nov 24th, 2014 - Effective treatment of children with medulloblastoma requires a functioning multi-disciplinary team with adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities and personnel. In addition the treating cent...

see more →

Drugs  7 results see all →

Clinicaltrials.gov  4,101 results

Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.
https://doi.org/10.1038/s41388-021-01701-z 10.1101/gad.938601 10.1016/j.ccr.2008.07.003 10.3390/jdb4020020 10.1038/ijos.2015.14 10.1016/j.bone.2017.06.014 10.1038/nature01657 10.1101/gad.13.16.2072 10.1038/nrc3079 10.1200/JCO.2009.27.4324 10.1200/JCO.2005.04.4974 10.1158/1078-0432.CCR-13-1425 10.1056/NEJMoa0902903 10.1016/j.ccell.2015.02.002 10.1016/j.ccell.2015.02.001 10.1098/rsob.180098 10.1038/sj.onc.1210467 10.1016/j.ccr.2008.01.027 10.1093/neuonc/nox109 10.18632/oncotarget.20619 10.1038/343425a0 10.1002/(SICI)1096-8628(20000214)90:4<339::AID-AJMG15>3.0.CO;2-5 10.1038/9700 10.1126/science.7985023 10.1016/S0092-8674(01)00369-5 10.1016/j.cell.2016.08.003 10.7554/eLife.20304 10.1038/nature18934 10.1158/1078-0432.CCR-17-2923 10.1016/j.str.2018.11.003 10.1073/pnas.1717891115 10.1007/978-1-4939-7493-1_17 10.1093/nar/gkaa216 10.1093/bioinformatics/btaa102 10.1016/j.csbj.2015.09.001 10.1002/bit.20828 10.1111/j.1476-5381.2009.00430.x 10.1016/j.jacl.2014.02.010 10.1111/j.1476-5381.2011.01724.x 10.1242/dev.056499 10.1038/nn.2467 10.1093/hmg/ddv042 10.1242/dev.162396 10.3109/03602539009041088 10.1016/S0009-9236(98)90034-0 10.1016/S0009-9236(98)90130-8 10.1111/j.1472-8206.2004.00299.x 10.1016/j.jacl.2017.11.007 10.1001/jama.2014.8892 10.1038/s41413-019-0078-3 10.1073/pnas.0608449104 10.1038/s41413-018-0034-7 10.1093/hmg/ddg129 10.1074/jbc.M305518200 10.1001/jama.1962.03050300059020a 10.1093/jn/110.11.2310 10.1016/S0140-6736(00)02400-4 10.1210/en.2002-220682 10.1001/jama.283.24.3211 10.1126/science.286.5446.1946 10.1016/j.ccell.2017.05.005 10.1016/S1470-2045(17)30243-7 10.1038/s41568-019-0223-8 10.1038/nprot.2008.95
Oncogene Fan Q, Gong T et. al.

Mar 2nd, 2021 - The Hedgehog (Hh) pathway plays an indispensable role in bone development and genetic activation of the pathway results in medulloblastoma (MB), the most common malignant brain tumor in children. Inhibitors of Hh pathway (such as vismodegib and so...

Intramedullary metastasis in medulloblastoma: a case report and literature review.
https://doi.org/10.1007/s00381-021-05086-y 10.3109/02688697.2011.603855 10.3171/jns.1986.65.2.0253 10.3171/jns.1978.48.4.0632 10.1016/j.wneu.2018.06.250 10.1007/s00381-006-0167-7 10.1159/000377729 10.1016/j.wneu.2012.04.005 10.3171/2015.5.FOCUS15143 10.1016/j.wneu.2018.05.216 10.1007/s00401-011-0922-z
Child's Nervous System : ChNS : Official Journal of the I... Jiang H, Luo T et. al.

Feb 27th, 2021 - Cerebellar medulloblastomas are the most common malignant tumors of the posterior fossa in childhood that frequently metastasize. Leptomeningeal dissemination and distant metastasis have been associated with medulloblastomas; however, intramedulla...

Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/...
https://doi.org/10.1080/15384047.2021.1883186
Cancer Biology & Therapy; Yang D, Ma X et. al.

Feb 26th, 2021 - Emerging documents revealed that E2 enzyme family has been implicated in regulating the progression of numerous human cancers. Ubiquitin-conjugating enzyme E2 J1 (UBE2J1), a member of E2 enzyme family, has been reported to participate in the biolo...

Paracrine placental growth factor signaling in response to ionizing radiation is p53-de...
https://doi.org/10.1158/1541-7786.MCR-20-0403
Molecular Cancer Research : MCR; Kazimova T, Tschanz F et. al.

Feb 23rd, 2021 - Placental growth factor (PlGF) is a pro-angiogenic, N-glycosylated growth factor, which is secreted under pathological situations. Here, we investigated the regulation of PlGF in response to ionizing radiation (IR) and its role for tumor angiogene...

Molecular determinants of medulloblastoma metastasis and leptomeningeal dissemination.
https://doi.org/10.1158/1541-7786.MCR-20-1026
Molecular Cancer Research : MCR; Li M, Deng Y et. al.

Feb 20th, 2021 - Medulloblastoma (MB) is the most common malignant brain cancer in pediatrics consisting of four molecular subgroups, namely wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. One of the biggest challenges in the clinical management of thi...

see more →

News  29 results

Better Intellectual Outcomes After Proton Beam for Brain Cancer
https://www.staging.medscape.com/viewarticle/923576

Jan 8th, 2020 - A new study shows that children with medulloblastoma who were treated with radiotherapy had better intellectual outcomes when the radiation was delivered as proton beam therapy compared to traditional photon radiotherapy. Proton beam radiotherapy ...

Better Intellectual Outcomes After Proton Beam for Brain Cancer
https://www.medscape.com/viewarticle/923576

Jan 8th, 2020 - A new study shows that children with medulloblastoma who were treated with radiotherapy had better intellectual outcomes when the radiation was delivered as proton beam therapy compared to traditional photon radiotherapy. Proton beam radiotherapy ...

Identifying Low-Risk Medulloblastoma to De-escalate Therapy
https://www.medscape.com/viewarticle/904596

Nov 7th, 2018 - Some children with the most common form of malignant brain cancer could receive lower-dose radiotherapy and chemotherapy, depending on the chromosome signature of their tumor. Such an approach would improve patients' quality of life and could pote...

Multiple solid tumors targeted by concept CAR T
https://www.mdedge.com/hematology-oncology/article/165978/sarcoma-gist/multiple-solid-tumors-targeted-concept-car-t/page/0/1

May 17th, 2018 - In contrast, B7-H3 is highly expressed on many different pediatric solid tumors, including rhabdomyosarcoma (95% of tumors stained), Ewing sarcoma (89%), Wilms tumor (100%), neuroblastoma (82%), ganglioneuroblastoma and ganglioneuroma (53%), medul.

CHMP recommends approval for generic carmustine
https://www.mdedge.com/hematology-oncology/article/184984/lymphoma-plasma-cell-disorders/chmp-recommends-approval-generic-carmustine
HT Staff

Apr 28th, 2018 - Hodgkin lymphoma Micrograph showing The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion of Carmustine Obvius, a generic version of Carmubris. The CHMP is recommending marketing autho.

see more →

Patient Education  3 results see all →