ALLMedicine™ Brainstem Gliomas Center
Research & Reviews 84 results
https://clinicaltrials.gov/ct2/show/NCT05310448
May 17th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the safety and tolerability of tumor treating fields in combination with standard of care radiotherapy and chemotherapy in patients with brainstem gliomas. SECONDARY OBJECTIVE: I. To evaluate the anti-tumor activi...
https://doi.org/10.21037/apm-22-22
Annals of Palliative Medicine; Zhu Y, Zhao L et. al.
Feb 12th, 2022 - Adult brainstem gliomas are characterized into subtypes depending on clinicopathologic and radiographic characteristics. Among them, brainstem glioblastoma is the most malignant and has the poorest prognosis, with surgical resection for this condi...
https://doi.org/10.1016/j.drudis.2021.12.016
Drug Discovery Today; Ni S, Chen R et. al.
Dec 27th, 2021 - As an intractable central nervous system (CNS) tumor, brainstem glioma (BG) is one of the leading causes of pediatric death by brain tumors. Owing to the risk of surgical resection and the little improvement in survival time after radiotherapy and...
https://clinicaltrials.gov/ct2/show/NCT01106794
Nov 8th, 2021 - High grade diffuse intrinsic pontine glioma (DIPG) accounts for approximately 80% of pediatric brainstem tumors and 10% of pediatric brain tumors, and is the most lethal form of brainstem gliomas in children. There is currently no effective therap...
https://doi.org/10.1016/j.critrevonc.2021.103508
Critical Reviews in Oncology/hematology; Gagliardi F, De Domenico P et. al.
Oct 23rd, 2021 - The current standard of care for surgically inaccessible low-grade brainstem gliomas (BS-LLGs) is external-beam radiotherapy (RT). Developments toward more innovative conformal techniques have focused on decreasing morbidity, by limiting radiation...
Clinicaltrials.gov 7 results
https://clinicaltrials.gov/ct2/show/NCT05310448
May 17th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the safety and tolerability of tumor treating fields in combination with standard of care radiotherapy and chemotherapy in patients with brainstem gliomas. SECONDARY OBJECTIVE: I. To evaluate the anti-tumor activi...
https://clinicaltrials.gov/ct2/show/NCT01106794
Nov 8th, 2021 - High grade diffuse intrinsic pontine glioma (DIPG) accounts for approximately 80% of pediatric brainstem tumors and 10% of pediatric brain tumors, and is the most lethal form of brainstem gliomas in children. There is currently no effective therap...
https://clinicaltrials.gov/ct2/show/NCT03932981
Sep 10th, 2021 - The goal of this study is to assess the impact (objective response) of first-line chemotherapy in infiltrative non-enhancing adult brainstem gliomas that are progressing in an infiltrative and non-threatening way. Upon progression, (radiotherapy) ...
https://clinicaltrials.gov/ct2/show/NCT00021229
Jul 31st, 2014 - PRIMARY OBJECTIVES: I. Determine the maximum tolerated dose (MTD) of imatinib mesylate after completion of radiation in children with newly diagnosed poor prognosis brainstem gliomas. (Phase I, strata I closed to accrual as of 5/28/04.) II. Determ...
https://clinicaltrials.gov/ct2/show/NCT00042991
May 28th, 2014 - PRIMARY OBJECTIVES: I. To define the safety of gefitinib administered in conjunction with irradiation in children with newly diagnosed non-disseminated diffuse intrinsic brainstem gliomas and newly diagnosed incompletely resected supratentorial ma...
News 1 results
https://reference.staging.medscape.com/viewarticle/844658_5
May 14th, 2015 - The prognosis of patients with diffuse intrinsic brainstem gliomas is poor, with a typical survival of less than 12 months after diagnosis. Treatment modalities are limited and have thus far failed to yield significant increases in survival. Given...
