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About 4,462 results

ALLMedicine™ Langerhans Cell Histiocytosis Center

Research & Reviews  2,211 results

Otologic Manifestations of Langerhans Cell Histiocytosis: A Systematic Review.
https://doi.org/10.1177/01945998211004590
Otolaryngology--head and Neck Surgery : Official Journal ... Chen T, Ashman PE et. al.

May 4th, 2021 - To perform a systematic review to investigate common otologic manifestations of Langerhans cell histiocytosis, the incidence of these findings, methods for diagnosis, as well as medical and surgical management. PubMed/MEDLINE, Embase, and Cochrane...

Histiocytic and Dendritic Cell Sarcomas of Hematopoietic Origin Share Targetable Genomi...
https://doi.org/10.1002/onco.13801
The Oncologist; Massoth L, Hung YP et. al.

Apr 27th, 2021 - Histiocytic and dendritic cell neoplasms are a diverse group of tumors arising from monocytic or dendritic cell lineage. Whereas the genomic features for Langerhans cell histiocytosis and Erdheim-Chester disease have been well described, other les...

BRAFV600E mutation in cell-free DNA, rather than in lesion tissues, at diagnosis is an ...
https://doi.org/10.1158/1535-7163.MCT-20-1075
Molecular Cancer Therapeutics; Wang C, Cui L et. al.

Apr 21st, 2021 - The aim of this study was to investigate the prognostic significance of BRAFV600E in cell-free (cf) DNA (cfBRAFV600E) and lesion tissues (ltBRAFV600E) in pediatric LCH. This study included a total of 140 patients with successfully detected cfBRAFV...

Oral Langerhans Cell Histiocytosis in Two Pediatric Patients.
https://www.ncbi.nlm.nih.gov/pubmed/33875056
Journal of Dentistry for Children (Chicago, Ill.); Caetano Guimarães AF, de Souza GA et. al.

Apr 20th, 2021 - We report two cases of Langerhans cell histiocytosis (LCH) in the oral cavity of children. An 11-month-old girl was referred for evaluation of a nodular and sessile lesion in the alveolar ridge covering the primary left mandibular central incisor....

Multicentric reticulohistiocytosis masquerading as cutaneous connective tissue disease.
https://www.ncbi.nlm.nih.gov/pubmed/33865276
Dermatology Online Journal; Fronek L, Bindernagel R et. al.

Apr 18th, 2021 - Multicentric reticulohistiocytosis (MRH) is a rare type of non-Langerhans cell histiocytosis characterized by coral-toned papules with predilection for dorsal surfaces in addition to severe arthropathy. It sometimes proves difficult to differentia...

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Guidelines  3 results

The Mayo Clinic Histiocytosis Working Group Consensus Statement for the Diagnosis and E...
https://doi.org/10.1016/j.mayocp.2019.02.023
Mayo Clinic Proceedings; Goyal G, Young JR et. al.

Sep 1st, 2019 - Histiocytic neoplasms, a rare and heterogeneous group of disorders, primarily include Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease. Due to their diverse clinical manifestations, the greatest challenge posed by ...

Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and tr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557042
Pediatric Blood & Cancer; Haupt R, Minkov M et. al.

Oct 30th, 2012 - These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in pee...

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Clinicaltrials.gov  2,221 results

Otologic Manifestations of Langerhans Cell Histiocytosis: A Systematic Review.
https://doi.org/10.1177/01945998211004590
Otolaryngology--head and Neck Surgery : Official Journal ... Chen T, Ashman PE et. al.

May 4th, 2021 - To perform a systematic review to investigate common otologic manifestations of Langerhans cell histiocytosis, the incidence of these findings, methods for diagnosis, as well as medical and surgical management. PubMed/MEDLINE, Embase, and Cochrane...

Histiocytic and Dendritic Cell Sarcomas of Hematopoietic Origin Share Targetable Genomi...
https://doi.org/10.1002/onco.13801
The Oncologist; Massoth L, Hung YP et. al.

Apr 27th, 2021 - Histiocytic and dendritic cell neoplasms are a diverse group of tumors arising from monocytic or dendritic cell lineage. Whereas the genomic features for Langerhans cell histiocytosis and Erdheim-Chester disease have been well described, other les...

BRAFV600E mutation in cell-free DNA, rather than in lesion tissues, at diagnosis is an ...
https://doi.org/10.1158/1535-7163.MCT-20-1075
Molecular Cancer Therapeutics; Wang C, Cui L et. al.

Apr 21st, 2021 - The aim of this study was to investigate the prognostic significance of BRAFV600E in cell-free (cf) DNA (cfBRAFV600E) and lesion tissues (ltBRAFV600E) in pediatric LCH. This study included a total of 140 patients with successfully detected cfBRAFV...

Oral Langerhans Cell Histiocytosis in Two Pediatric Patients.
https://www.ncbi.nlm.nih.gov/pubmed/33875056
Journal of Dentistry for Children (Chicago, Ill.); Caetano Guimarães AF, de Souza GA et. al.

Apr 20th, 2021 - We report two cases of Langerhans cell histiocytosis (LCH) in the oral cavity of children. An 11-month-old girl was referred for evaluation of a nodular and sessile lesion in the alveolar ridge covering the primary left mandibular central incisor....

Multicentric reticulohistiocytosis masquerading as cutaneous connective tissue disease.
https://www.ncbi.nlm.nih.gov/pubmed/33865276
Dermatology Online Journal; Fronek L, Bindernagel R et. al.

Apr 18th, 2021 - Multicentric reticulohistiocytosis (MRH) is a rare type of non-Langerhans cell histiocytosis characterized by coral-toned papules with predilection for dorsal surfaces in addition to severe arthropathy. It sometimes proves difficult to differentia...

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News  27 results

A 6-Year-Old Boy With Fever and Bone Swelling: Osmosis USMLE Study Question
https://www.staging.medscape.com/viewarticle/899198_2

Mar 5th, 2020 - Langerhans cell histiocytosis (LCH) is a neoproliferative disorder of Langerhans cells, the dendritic cells of the skin the mucosa. It often involves osteolytic bone lesions and invasion of multiple organs. There are tennis racket-shaped inclusion...

Hemorrhagic Crusted Papule on the Arm
https://www.mdedge.com/dermatology/article/178553/pediatrics/hemorrhagic-crusted-papule-arm
Somya Abubucker, MD, Jonathan Cuda, MD et. al.

Oct 31st, 2018 - The Diagnosis: Self-healing Langerhans Cell Histiocytosis Histopathologic examination showed an infiltrate of mononuclear cells with indented nuclei admixed with a variable dermal inflammatory infiltrate. Immunohistochemistry demonstrated cells th.

Vemurafenib granted sNDA, priority review for Erdheim-Chester disease
https://www.mdedge.com/hematology-oncology/article/144120/myelodysplastic-syndrome/vemurafenib-granted-snda-priority-review
Mary Jo M. Dales

Aug 7th, 2017 - Vemurafenib (Zelboraf) has been granted a supplemental new drug application and priority review by the Food and Drug Administration for the treatment of Erdheim-Chester disease with BRAF V600 mutation, according to a press release issued by Genent.

Purpuric Lesions of the Scalp, Axillae, and Groin of an Infant
https://www.mdedge.com/dermatology/article/139848/pediatrics/purpuric-lesions-scalp-axillae-and-groin-infant
Michele Khurana, MD, Jonathan S. Leventhal, MD et. al.

Jun 6th, 2017 - The Diagnosis: Langerhans Cell Histiocytosis Langerhans cell histiocytosis (LCH) is a clonal proliferative disorder of Langerhans cells that can affect any organ, most commonly the skin and bones. It typically develops in children aged 1 to 3 year.

Pediatric Dermatology Consult - April 2017
https://www.mdedge.com/familymedicine/article/136266/pediatric-dermatology-consult-april-2017
Pediatric News;

Apr 21st, 2017 - BY JEREMY UDKOFF AND CATALINA MATIZ, MD Juvenile xanthogranuloma (JXG), a non–Langerhans cell histiocytosis, is a common pediatric tumor that most commonly presents either at birth, in infants, or in young children – with the majority of cases occ.

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