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About 118 results

ALLMedicine™ Granular Corneal Dystrophy Center

Research & Reviews  46 results

Atypical Conjunctival Hyaline Deposition in a Case of Granular Corneal Dystrophy Type 2.
https://doi.org/10.1016/j.ajo.2022.04.012
American Journal of Ophthalmology; Kumada M, Sumi T et. al.

May 6th, 2022 - Atypical Conjunctival Hyaline Deposition in a Case of Granular Corneal Dystrophy Type 2.|2022|Kumada M,Sumi T,Iguchi M,Yamada N,Fukuda K,|

Detailed phenotypic description of stromal corneal dystrophy in a large pedigree carryi...
https://doi.org/10.1080/13816810.2022.2068047
Ophthalmic Genetics; Irusteta L, Ramírez-Miranda A et. al.

Apr 27th, 2022 - The purpose of this study is to describe the corneal clinical spectrum and the intrafamilial phenotypic differences in an extended pedigree suffering from stromal corneal dystrophy due to the rare p.Ala546Asp mutation in TGFBI. A total of 15 membe...

Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TG...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037417
Autophagy Wang L, Zhao C et. al.

Aug 18th, 2021 - Thiel-Behnke corneal dystrophy (TBCD) is an epithelial-stromal TGFBI dystrophy caused by mutations in the TGFBI (transforming growth factor beta induced) gene, though the underlying mechanisms and pathogenesis of TBCD are still obscure. The study ...

Prevalence of granular corneal dystrophy type 2-related TGFBI p.R124H variant in a Sout...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116257
Molecular Vision; Park JE, Yun SA et. al.

May 21st, 2021 - Granular corneal dystrophy type 2 (GCD2) is an autosomal dominant disorder and is associated with the arginine to histidine substitution at codon 124 (p.R124H) of the TGFBI gene. Although TGFBI p.R124H is known to be the most common corneal dystro...

Exacerbation of Granular Corneal Dystrophy Type 2 After Small Incision Lenticule Extrac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938913
Cornea Kwak JJ, Yoon SH et. al.

Feb 10th, 2021 - To report the outcome of unilateral small incision lenticule extraction (SMILE) in a patient with granular corneal dystrophy type 2 (GCD2). Slit-lamp photography and Fourier domain optical coherence tomography were used to document the clinical co...

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Clinicaltrials.gov  1 results

Study of the Prevalence of TGFBI Corneal Dystrophies
https://clinicaltrials.gov/ct2/show/NCT02746055

Apr 22nd, 2016 - It is well established in the peer-reviewed literature that elective keratorefractive surgery is contraindicated in individuals with granular corneal dystrophy type 2 (GCD2).1,2,3,4 Although all reported cases of exacerbation of dystrophic stromal...

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