ALLMedicine™ Ichthyosis Center
Research & Reviews 636 results
http://emedicine.medscape.com/article/910223-overview
May 10th, 2022 - Practice Essentials Keratosis pilaris is a very common, benign, heritable disorder of keratinized hair follicles. [1] It is characterized by grouped, horny, keratotic, follicular papules, predominantly located over the extensor surfaces of the pro...
https://doi.org/10.1111/jdv.18189
Journal of the European Academy of Dermatology and Venere... Mo R, Lin M et. al.
May 2nd, 2022 - Epidermolytic palmoplantar keratoderma (EPPK) is characterized by diffuse hyperkeratosis affecting palms and soles with suprabasal epidermolysis or vacuolar degeneration histopathologically. The disorder is caused by heterozygous mutations in KRT9...
https://clinicaltrials.gov/ct2/show/NCT04549792
Apr 20th, 2022 - The ichthyoses are a group of lifelong genetic disorders that share characteristics of generalized skin thickening, scaling and underlying cutaneous inflammation. The vast majority are orphan disorders and are associated with extremely poor qualit...
https://doi.org/10.1111/jocd.15000
Journal of Cosmetic Dermatology; Jiao Q, Zhi L et. al.
Apr 19th, 2022 - stratum corneum is located in the outermost layer of the skin and is the most important part of the skin barrier. stratum corneum mainly contains keratinocytes, lipid and desmosomes. Their normal metabolic process is closely related to the functio...
https://doi.org/10.1016/j.jid.2022.03.022
The Journal of Investigative Dermatology; Kim M, Mikhaylov D et. al.
Apr 15th, 2022 - Preliminary work suggested upregulation of inflammatory pathways in patients with common forms of ichthyosis. However, a comprehensive characterization of skin from various ichthyosis subtypes is unavailable, precluding the development of targeted...
Guidelines 1 results
https://doi.org/10.1111/bjd.16882
The British Journal of Dermatology; Mazereeuw-Hautier J, Hernández-Martín A et. al.
Jun 14th, 2018 - These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group of European experts following a systematic review of the current literature, an expert conference held in Toulouse in 2016, and a consens...
Drugs 44 results see all →
Clinicaltrials.gov 8 results
https://clinicaltrials.gov/ct2/show/NCT04549792
Apr 20th, 2022 - The ichthyoses are a group of lifelong genetic disorders that share characteristics of generalized skin thickening, scaling and underlying cutaneous inflammation. The vast majority are orphan disorders and are associated with extremely poor qualit...
https://clinicaltrials.gov/ct2/show/NCT04154293
Oct 5th, 2021 - The purpose of this study is to investigate the efficacy and safety of two concentrations of topically applied ointment formulation of isotretinoin called TMB-001 (0.05% and 0.1% isotretinoin) in subjects 9 years of age and older for the treatment...
https://clinicaltrials.gov/ct2/show/NCT04047732
Sep 13th, 2021 - Up to six adult subjects are planned for the Phase I portion of this study. Subjects are enrolled upon obtaining consent and meeting entry criteria. This study is an intra-patient comparison of KB105 and placebo-administered Target Areas. Patients...
https://clinicaltrials.gov/ct2/show/NCT02402309
Jul 21st, 2021 - This is a multi-center, randomized, double-blind, vehicle-controlled, parallel-group study designed to evaluate the safety, PK, and exploratory activity of topically-applied NS2 dermatologic cream administered once-daily (QD) to subjects with icht...
https://clinicaltrials.gov/ct2/show/NCT03641261
Aug 25th, 2020 - The main purpose is to evaluate the feasibility (global use) of a therapeutic patient education program using a specific web application in patients with hereditary ichthyosis.
News 38 results
https://www.medscape.com/viewarticle/970990
Mar 27th, 2022 - Patients with recessive X-linked and autosomal recessive lamellar congenital ichthyosis (CI) achieved treatment success with a novel topical isotretinoin ointment known as TMB-001, results from a phase 2b study demonstrated. "Patients with these d...
https://www.medscape.com/viewarticle/949188
Apr 13th, 2021 - For as many disorders of cornification and types of ichthyosis that have been shown to benefit from retinoids, a seemingly equal number have no data or show no improvement. According to a consensus statement published in the February issue of Pedi...
https://www.medscape.com/viewarticle/945212
Feb 3rd, 2021 - Clinicians using systemic retinoids for treating ichthyosis and other disorders of cornification (DOC) in children and adolescents should aim for the lowest dose possible to balance therapeutic goals with acceptable toxicity levels, advised the au...
https://www.medscape.com/viewarticle/927658
Mar 27th, 2020 - One of the aphorisms in dermatology, according to Lawrence Eichenfield, MD, is that prescription pads have become suggestion pads. Patients face consistent head-on refusals from insurers to fill off-label prescriptions for the many dermatologic co...
https://www.reuters.com/article/brief-aldeyra-therapeutics-provides-upda/brief-aldeyra-therapeutics-provides-updates-on-anticipated-clinical-milestones-idUSASA00HFO
Mar 12th, 2020 - March 12 (Reuters) - Aldeyra Therapeutics Inc: * ALDEYRA THERAPEUTICS REPORTS FULL-YEAR 2019 FINANCIAL RESULTS AND PROVIDES UPDATES ON ANTICIPATED CLINICAL MILESTONES * ALDEYRA THERAPEUTICS - STRATEGIC PRIORITIZATION OF LATE-STAGE OCULAR PIPELINE ...