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About 1,818 results

ALLMedicine™ Ichthyosis Center

Research & Reviews  636 results

Pediatric Keratosis Pilaris
http://emedicine.medscape.com/article/910223-overview

May 10th, 2022 - Practice Essentials Keratosis pilaris is a very common, benign, heritable disorder of keratinized hair follicles. [1] It is characterized by grouped, horny, keratotic, follicular papules, predominantly located over the extensor surfaces of the pro...

Nonsense mutations in KRT1 caused recessive epidermolytic palmoplantar keratoderma with...
https://doi.org/10.1111/jdv.18189
Journal of the European Academy of Dermatology and Venere... Mo R, Lin M et. al.

May 2nd, 2022 - Epidermolytic palmoplantar keratoderma (EPPK) is characterized by diffuse hyperkeratosis affecting palms and soles with suprabasal epidermolysis or vacuolar degeneration histopathologically. The disorder is caused by heterozygous mutations in KRT9...

An Open-Label and Long-Term Extension Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Patients With Ichthyoses
https://clinicaltrials.gov/ct2/show/NCT04549792

Apr 20th, 2022 - The ichthyoses are a group of lifelong genetic disorders that share characteristics of generalized skin thickening, scaling and underlying cutaneous inflammation. The vast majority are orphan disorders and are associated with extremely poor qualit...

Studies on stratum corneum metabolism: function, molecular mechanism and influencing fa...
https://doi.org/10.1111/jocd.15000
Journal of Cosmetic Dermatology; Jiao Q, Zhi L et. al.

Apr 19th, 2022 - stratum corneum is located in the outermost layer of the skin and is the most important part of the skin barrier. stratum corneum mainly contains keratinocytes, lipid and desmosomes. Their normal metabolic process is closely related to the functio...

Transcriptomic Analysis of the Major Orphan Ichthyosis Subtypes Reveals Shared Immune a...
https://doi.org/10.1016/j.jid.2022.03.022
The Journal of Investigative Dermatology; Kim M, Mikhaylov D et. al.

Apr 15th, 2022 - Preliminary work suggested upregulation of inflammatory pathways in patients with common forms of ichthyosis. However, a comprehensive characterization of skin from various ichthyosis subtypes is unavailable, precluding the development of targeted...

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Guidelines  1 results

Management of congenital ichthyoses: European guidelines of care, part two.
https://doi.org/10.1111/bjd.16882
The British Journal of Dermatology; Mazereeuw-Hautier J, Hernández-Martín A et. al.

Jun 14th, 2018 - These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group of European experts following a systematic review of the current literature, an expert conference held in Toulouse in 2016, and a consens...

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Drugs  44 results see all →

Clinicaltrials.gov  8 results

An Open-Label and Long-Term Extension Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Patients With Ichthyoses
https://clinicaltrials.gov/ct2/show/NCT04549792

Apr 20th, 2022 - The ichthyoses are a group of lifelong genetic disorders that share characteristics of generalized skin thickening, scaling and underlying cutaneous inflammation. The vast majority are orphan disorders and are associated with extremely poor qualit...

A Vehicle Controlled Study to Evaluate Safety and Efficacy of Topical TMB-001 for Treatment of Congenital Ichthyosis
https://clinicaltrials.gov/ct2/show/NCT04154293

Oct 5th, 2021 - The purpose of this study is to investigate the efficacy and safety of two concentrations of topically applied ointment formulation of isotretinoin called TMB-001 (0.05% and 0.1% isotretinoin) in subjects 9 years of age and older for the treatment...

Topical KB105 Gene Therapy for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI)
https://clinicaltrials.gov/ct2/show/NCT04047732

Sep 13th, 2021 - Up to six adult subjects are planned for the Phase I portion of this study. Subjects are enrolled upon obtaining consent and meeting entry criteria. This study is an intra-patient comparison of KB105 and placebo-administered Target Areas. Patients...

A Study of Topical NS2 Cream to Treat Ichthyosis in Sjögren-Larsson Syndrome (SLS)
https://clinicaltrials.gov/ct2/show/NCT02402309

Jul 21st, 2021 - This is a multi-center, randomized, double-blind, vehicle-controlled, parallel-group study designed to evaluate the safety, PK, and exploratory activity of topically-applied NS2 dermatologic cream administered once-daily (QD) to subjects with icht...

Therapeutic Education Using an Internet Application in Hereditary Ichthyosis
https://clinicaltrials.gov/ct2/show/NCT03641261

Aug 25th, 2020 - The main purpose is to evaluate the feasibility (global use) of a therapeutic patient education program using a specific web application in patients with hereditary ichthyosis.

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News  38 results

Novel Isotretinoin Ointment For Congenital Ichthyosis Shows Promise
https://www.medscape.com/viewarticle/970990

Mar 27th, 2022 - Patients with recessive X-linked and autosomal recessive lamellar congenital ichthyosis (CI) achieved treatment success with a novel topical isotretinoin ointment known as TMB-001, results from a phase 2b study demonstrated. "Patients with these d...

Despite New Ichthyosis Treatment Recommendations, 'Many Questions Still Exist'
https://www.medscape.com/viewarticle/949188

Apr 13th, 2021 - For as many disorders of cornification and types of ichthyosis that have been shown to benefit from retinoids, a seemingly equal number have no data or show no improvement. According to a consensus statement published in the February issue of Pedi...

Consensus Statement Issued on Retinoids for Ichthyosis, Disorders of Cornification
https://www.medscape.com/viewarticle/945212

Feb 3rd, 2021 - Clinicians using systemic retinoids for treating ichthyosis and other disorders of cornification (DOC) in children and adolescents should aim for the lowest dose possible to balance therapeutic goals with acceptable toxicity levels, advised the au...

Off-Label Prescribing Off Limits, Leaving Some Untreated
https://www.medscape.com/viewarticle/927658

Mar 27th, 2020 - One of the aphorisms in dermatology, according to Lawrence Eichenfield, MD, is that prescription pads have become suggestion pads. Patients face consistent head-on refusals from insurers to fill off-label prescriptions for the many dermatologic co...

BRIEF-Aldeyra Therapeutics Provides Updates On Anticipated Clinical Milestones
https://www.reuters.com/article/brief-aldeyra-therapeutics-provides-upda/brief-aldeyra-therapeutics-provides-updates-on-anticipated-clinical-milestones-idUSASA00HFO

Mar 12th, 2020 - March 12 (Reuters) - Aldeyra Therapeutics Inc: * ALDEYRA THERAPEUTICS REPORTS FULL-YEAR 2019 FINANCIAL RESULTS AND PROVIDES UPDATES ON ANTICIPATED CLINICAL MILESTONES * ALDEYRA THERAPEUTICS - STRATEGIC PRIORITIZATION OF LATE-STAGE OCULAR PIPELINE ...

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