ALLMedicine™ Xeroderma Pigmentosum Center
Research & Reviews 438 results
https://clinicaltrials.gov/ct2/show/NCT00046189
Jan 26th, 2023 - Xeroderma Pigmentosum (XP) is a rare, recessive disorder with a more than 1000-fold increase in the frequency of all major skin cancers in association with defective DNA repair. The risk of skin and other cancers among normal appearing XP heterozy...
https://clinicaltrials.gov/ct2/show/NCT00001813
Jan 26th, 2023 - Three rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination...
https://clinicaltrials.gov/ct2/show/NCT05370235
Jan 20th, 2023 - The CUV152 study will evaluate the safety of afamelanotide in XP-C and XP-V patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increas...
https://doi.org/10.1001/jamadermatol.2022.5261
JAMA Dermatology; Kim J, Savory SA et. al.
Dec 22nd, 2022 - Prevention of Skin Cancers With Topical Calcipotriol and Fluorouracil in Patients With Xeroderma Pigmentosum.|2022|Kim J,Savory SA,Demehri S,Gill JG,|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712435
Nature Communications; Li F, Sun H et. al.
Dec 1st, 2022 - Platinum (Pt) resistance in cancer almost inevitably occurs during clinical Pt-based chemotherapy. The spontaneous nucleotide-excision repair of cancer cells is a representative process that leads to Pt resistance, which involves the local DNA ben...
Drugs 3 results see all →
Clinicaltrials.gov 15 results
https://clinicaltrials.gov/ct2/show/NCT00046189
Jan 26th, 2023 - Xeroderma Pigmentosum (XP) is a rare, recessive disorder with a more than 1000-fold increase in the frequency of all major skin cancers in association with defective DNA repair. The risk of skin and other cancers among normal appearing XP heterozy...
https://clinicaltrials.gov/ct2/show/NCT00001813
Jan 26th, 2023 - Three rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination...
https://clinicaltrials.gov/ct2/show/NCT05370235
Jan 20th, 2023 - The CUV152 study will evaluate the safety of afamelanotide in XP-C and XP-V patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increas...
https://clinicaltrials.gov/ct2/show/NCT05484570
Nov 8th, 2022 - This will be a single-center, single-arm, non-interventional natural history study to evaluate the longitudinal clinical course, functional outcome measures, and candidate biomarkers for individuals with DNA repair disorders, including Cockayne sy...
https://clinicaltrials.gov/ct2/show/NCT05159752
Sep 28th, 2022 - The CUV156 study will evaluate the safety of afamelanotide in XP-C patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increases the am...
News 18 results
https://www.onclive.com/view/dna-damage-response-a-constant-effort-to-maintain-cell-integrity-might-help-cancer-patients-after-all
Dec 20th, 2020 - Andre Goy, MD Editor-in-Chief of Oncology & Biotech News Chairman and Director Chief of Lymphoma Director, Clinical and Translational Cancer Research John Theurer Cancer Center at Hackensack University Medical Center The pr...
https://www.onclive.com/view/updates-and-advances-in-basal-cell-carcinoma
Dec 18th, 2020 - Although basal cell carcinoma (BCC) generally has a good prognosis, improving tolerance to targeted Hedgehog (HH) inhibitors and optimizing second-line treatment with immune checkpoint inhibitors are important for the small subset of patients who ...
https://www.onclive.com/view/researchers-identify-gene-involved-in-dna-repair-from-uvb-damage
Dec 4th, 2020 - UV radiation DNA damage. (Illustration by David Herring) The tumor suppressor gene PTEN has been linked to the removal of DNA damage from UVB radiation, a major risk factor in the development of skin cancer. The discovery may help researchers to ...
https://reference.medscape.com/viewarticle/936083_2
Aug 21st, 2020 - Primary risk factors and clinical warning signs for melanoma include: Changing mole (most important clinical warning sign) Presence of xeroderma pigmentosum or familial atypical mole melanoma syndrome Clinical atypical/dysplastic nevi in familial ...
https://www.medscape.com/viewarticle/923186
Dec 28th, 2019 - Simon Stevens, head of NHS England becomes a Sir, leading this year's healthcare field in the 2020 New Year Honours List. The recipients in healthcare are alongside stars of sport, entertainment, public service, politics, charity work, and "the ou...