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About 1,188 results

ALLMedicine™ Xeroderma Pigmentosum Center

Research & Reviews  438 results

Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum
https://clinicaltrials.gov/ct2/show/NCT00046189

Jan 26th, 2023 - Xeroderma Pigmentosum (XP) is a rare, recessive disorder with a more than 1000-fold increase in the frequency of all major skin cancers in association with defective DNA repair. The risk of skin and other cancers among normal appearing XP heterozy...

Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy
https://clinicaltrials.gov/ct2/show/NCT00001813

Jan 26th, 2023 - Three rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination...

A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V
https://clinicaltrials.gov/ct2/show/NCT05370235

Jan 20th, 2023 - The CUV152 study will evaluate the safety of afamelanotide in XP-C and XP-V patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increas...

Prevention of Skin Cancers With Topical Calcipotriol and Fluorouracil in Patients With ...
https://doi.org/10.1001/jamadermatol.2022.5261
JAMA Dermatology; Kim J, Savory SA et. al.

Dec 22nd, 2022 - Prevention of Skin Cancers With Topical Calcipotriol and Fluorouracil in Patients With Xeroderma Pigmentosum.|2022|Kim J,Savory SA,Demehri S,Gill JG,|

A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712435
Nature Communications; Li F, Sun H et. al.

Dec 1st, 2022 - Platinum (Pt) resistance in cancer almost inevitably occurs during clinical Pt-based chemotherapy. The spontaneous nucleotide-excision repair of cancer cells is a representative process that leads to Pt resistance, which involves the local DNA ben...

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Drugs  3 results see all →

Clinicaltrials.gov  15 results

Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum
https://clinicaltrials.gov/ct2/show/NCT00046189

Jan 26th, 2023 - Xeroderma Pigmentosum (XP) is a rare, recessive disorder with a more than 1000-fold increase in the frequency of all major skin cancers in association with defective DNA repair. The risk of skin and other cancers among normal appearing XP heterozy...

Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy
https://clinicaltrials.gov/ct2/show/NCT00001813

Jan 26th, 2023 - Three rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination...

A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V
https://clinicaltrials.gov/ct2/show/NCT05370235

Jan 20th, 2023 - The CUV152 study will evaluate the safety of afamelanotide in XP-C and XP-V patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increas...

Natural History Study for DNA Repair Disorders
https://clinicaltrials.gov/ct2/show/NCT05484570

Nov 8th, 2022 - This will be a single-center, single-arm, non-interventional natural history study to evaluate the longitudinal clinical course, functional outcome measures, and candidate biomarkers for individuals with DNA repair disorders, including Cockayne sy...

A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum (XP)
https://clinicaltrials.gov/ct2/show/NCT05159752

Sep 28th, 2022 - The CUV156 study will evaluate the safety of afamelanotide in XP-C patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increases the am...

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News  18 results

DNA Damage Response: A Constant Effort to Maintain Cell Integrity Might Help Cancer Patients After All
https://www.onclive.com/view/dna-damage-response-a-constant-effort-to-maintain-cell-integrity-might-help-cancer-patients-after-all

Dec 20th, 2020 - Andre Goy, MD Editor-in-Chief of Oncology & Biotech News Chairman and Director Chief of Lymphoma Director, Clinical and Translational Cancer Research John Theurer Cancer Center at Hackensack University Medical Center The pr...

Updates and Advances in Basal Cell Carcinoma
https://www.onclive.com/view/updates-and-advances-in-basal-cell-carcinoma

Dec 18th, 2020 - Although basal cell carcinoma (BCC) generally has a good prognosis, improving tolerance to targeted Hedgehog (HH) inhibitors and optimizing second-line treatment with immune checkpoint inhibitors are important for the small subset of patients who ...

Researchers Identify Gene Involved in DNA Repair From UVB Damage
https://www.onclive.com/view/researchers-identify-gene-involved-in-dna-repair-from-uvb-damage

Dec 4th, 2020 - UV radiation DNA damage. (Illustration by David Herring) The tumor suppressor gene PTEN has been linked to the removal of DNA damage from UVB radiation, a major risk factor in the development of skin cancer. The discovery may help researchers to ...

Fast Five Quiz: Malignant Melanoma
https://reference.medscape.com/viewarticle/936083_2

Aug 21st, 2020 - Primary risk factors and clinical warning signs for melanoma include: Changing mole (most important clinical warning sign) Presence of xeroderma pigmentosum or familial atypical mole melanoma syndrome Clinical atypical/dysplastic nevi in familial ...

NHS England Boss Knighted in New Year Honours
https://www.medscape.com/viewarticle/923186

Dec 28th, 2019 - Simon Stevens, head of NHS England becomes a Sir, leading this year's healthcare field in the 2020 New Year Honours List. The recipients in healthcare are alongside stars of sport, entertainment, public service, politics, charity work, and "the ou...

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Patient Education  1 results see all →